Lauren Z Davis1, George M Slavich2, Premal H Thaker3, Michael J Goodheart4, David P Bender4, Laila Dahmoush5, Donna M Farley6, Kristian E Markon1, Frank J Penedo7,8,9, David M Lubaroff10,11,12, Steve W Cole2,13,14, Anil K Sood15,16, Susan K Lutgendorf1,4,10,11. 1. Department of Psychology, University of Iowa, Iowa City, Iowa. 2. Cousins Center for Psychoneuroimmunology, Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, California. 3. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri. 4. Department of Obstetrics and Gynecology, University of Iowa, Iowa City, Iowa. 5. Department of Pathology, University of Iowa, Iowa City, Iowa. 6. College of Pharmacy, University of Iowa, Iowa City, Iowa. 7. Department of Medical and Social Sciences, Northwestern University, Evanston, Illinois. 8. Department of Psychology, Northwestern University, Evanston, Illinois. 9. Department of Psychiatry and Behavioral Sciences, Northwestern University, Evanston, Illinois. 10. Department of Urology, University of Iowa, Iowa City, Iowa. 11. Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa. 12. Department of Microbiology, University of Iowa, Iowa City, Iowa. 13. Division of Hematology/Oncology, Jonsson Comprehensive Cancer Center, University of California at Los Angeles School of Medicine, Los Angeles, California. 14. University of California at Los Angeles Molecular Biology Institute, Los Angeles, California. 15. Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. 16. Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Abstract
BACKGROUND: The impact of psychological well-being on the physiologic processes involved in cancer progression remains unclear. Prior research has implicated adrenergic signaling in tumor growth and metastasis. Given that adrenergic signaling is influenced by both positive and negative factors, the authors examined how 2 different aspects of well-being (eudaimonic and positive affect) and psychological distress were associated with tumor norepinephrine (NE) in patients with ovarian cancer. METHODS: A total of 365 women with suspected ovarian cancer completed psychosocial assessments before surgery and clinical information was obtained from medical records. Study inclusion was confirmed after histological diagnosis. Tumor NE was measured in frozen tissue samples using high-performance liquid chromatography with electrochemical detection. Confirmatory factor analysis was used to model eudaimonic well-being, positive affect, and psychological distress, and structural equation modeling was used to examine associations between these factors and tumor NE. RESULTS: Eudaimonic well-being, positive affect, and psychological distress, modeled as distinct but correlated constructs, best fit the data (ie, compared with unitary or 2-factor models) (root mean square error of approximation, 0.048; comparative fit index, 0.982; and standardized root-mean-squared residual, 0.035). Structural equation modeling analysis that included physical well-being, stage of disease, histology, psychological treatment history, beta-blocker use, and caffeine use as covariates was found to have good model fit (root mean square error of approximation, 0.052; comparative fit index, 0.955; and standardized root-mean-squared residual, 0.036) and demonstrated that eudaimonic well-being was related to lower tumor NE (β = -.24 [P = .045]). In contrast, no effects were found for positive affect or psychological distress. CONCLUSIONS: Eudaimonic well-being was found to be associated with lower tumor NE, independent of positive affect and psychological distress. Because adrenergic signaling is implicated in tumor progression, increasing eudaimonic well-being may improve both psychological and physiologic resilience in patients with ovarian cancer.
BACKGROUND: The impact of psychological well-being on the physiologic processes involved in cancer progression remains unclear. Prior research has implicated adrenergic signaling in tumor growth and metastasis. Given that adrenergic signaling is influenced by both positive and negative factors, the authors examined how 2 different aspects of well-being (eudaimonic and positive affect) and psychological distress were associated with tumornorepinephrine (NE) in patients with ovarian cancer. METHODS: A total of 365 women with suspected ovarian cancer completed psychosocial assessments before surgery and clinical information was obtained from medical records. Study inclusion was confirmed after histological diagnosis. Tumor NE was measured in frozen tissue samples using high-performance liquid chromatography with electrochemical detection. Confirmatory factor analysis was used to model eudaimonic well-being, positive affect, and psychological distress, and structural equation modeling was used to examine associations between these factors and tumor NE. RESULTS: Eudaimonic well-being, positive affect, and psychological distress, modeled as distinct but correlated constructs, best fit the data (ie, compared with unitary or 2-factor models) (root mean square error of approximation, 0.048; comparative fit index, 0.982; and standardized root-mean-squared residual, 0.035). Structural equation modeling analysis that included physical well-being, stage of disease, histology, psychological treatment history, beta-blocker use, and caffeine use as covariates was found to have good model fit (root mean square error of approximation, 0.052; comparative fit index, 0.955; and standardized root-mean-squared residual, 0.036) and demonstrated that eudaimonic well-being was related to lower tumor NE (β = -.24 [P = .045]). In contrast, no effects were found for positive affect or psychological distress. CONCLUSIONS: Eudaimonic well-being was found to be associated with lower tumor NE, independent of positive affect and psychological distress. Because adrenergic signaling is implicated in tumor progression, increasing eudaimonic well-being may improve both psychological and physiologic resilience in patients with ovarian cancer.
Authors: Susan K Lutgendorf; Koen DeGeest; Laila Dahmoush; Donna Farley; Frank Penedo; David Bender; Michael Goodheart; Thomas E Buekers; Luis Mendez; Gina Krueger; Lauren Clevenger; David M Lubaroff; Anil K Sood; Steve W Cole Journal: Brain Behav Immun Date: 2010-10-16 Impact factor: 7.217
Authors: Susan K Lutgendorf; Steven Cole; Erin Costanzo; Sarah Bradley; Jeremy Coffin; Sarvenaz Jabbari; Kaitlin Rainwater; Justine M Ritchie; Maria Yang; Anil K Sood Journal: Clin Cancer Res Date: 2003-10-01 Impact factor: 12.531
Authors: Barbara L Fredrickson; Karen M Grewen; Kimberly A Coffey; Sara B Algoe; Ann M Firestine; Jesusa M G Arevalo; Jeffrey Ma; Steven W Cole Journal: Proc Natl Acad Sci U S A Date: 2013-07-29 Impact factor: 11.205
Authors: Susan K Lutgendorf; Eileen Shinn; Jeanne Carter; Susan Leighton; Keith Baggerly; Michele Guindani; Bryan Fellman; Marianne Matzo; George M Slavich; Marc T Goodman; William Tew; Jenny Lester; Kathleen M Moore; Beth Y Karlan; Douglas A Levine; Anil K Sood Journal: Gynecol Oncol Date: 2017-05-17 Impact factor: 5.482
Authors: Michaela G Cuneo; Angela Szeto; Andrew Schrepf; Premal H Thaker; Michael Goodheart; Steve W Cole; Anil K Sood; Philip M McCabe; Armando J Mendez; Susan K Lutgendorf Journal: Psychosom Med Date: 2021-06-01 Impact factor: 3.864
Authors: Daniela B Bastos; Bruna A M Sarafim-Silva; Maria Lúcia M M Sundefeld; Amanda A Ribeiro; Juliana D P Brandão; Éder R Biasoli; Glauco I Miyahara; Dulce E Casarini; Daniel G Bernabé Journal: PLoS One Date: 2018-08-20 Impact factor: 3.240