Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Antimicrobial peptide shows enhanced activity and reduced toxicity upon grafting to chitosan polymers.

Literature DB >> 26096124

Antimicrobial peptide shows enhanced activity and reduced toxicity upon grafting to chitosan polymers.

Priyanka Sahariah¹, Kasper K Sørensen, Martha Á Hjálmarsdóttir, Ólafur E Sigurjónsson, Knud J Jensen, Már Másson, Mikkel B Thygesen.

Abstract

Here we report that grafting of a short antimicrobial peptide, anoplin, to chitosan polymers is a strategy for abolishing the hemolytic propensity, and at the same time increasing the activity of the parent peptide. Anoplin-chitosan conjugates were synthesized by CuAAC reaction of multiple peptides through 2-azidoacetyl groups on chitosan.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2015 PMID： 26096124 DOI： 10.1039/c5cc04010h

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

Keyword Cloud
Cited

12 in total

1. Antimicrobial and antibiofilm activity of curcumin-silver nanoparticles with improved stability and selective toxicity to bacteria over mammalian cells.

Authors: Swati Jaiswal; Prashant Mishra
Journal: Med Microbiol Immunol Date: 2017-10-28 Impact factor: 3.402

2. Temperature-Controlled Reversible Exposure and Hiding of Antimicrobial Peptides on an Implant for Killing Bacteria at Room Temperature and Improving Biocompatibility in Vivo.

Authors: Jiezhao Zhan; Lin Wang; Yuchen Zhu; Huichang Gao; Yunhua Chen; Junjian Chen; Yongguang Jia; Jingcai He; Zhou Fang; Ye Zhu; Chuanbin Mao; Li Ren; Yingjun Wang
Journal: ACS Appl Mater Interfaces Date: 2018-10-11 Impact factor: 9.229

Review 3. Antimicrobial Peptides: Diversity, Mechanism of Action and Strategies to Improve the Activity and Biocompatibility In Vivo.

Authors: Prashant Kumar; Jayachandran N Kizhakkedathu; Suzana K Straus
Journal: Biomolecules Date: 2018-01-19

4. Are Antimicrobial Peptide Dendrimers an Escape from ESKAPE?

Authors: Yayoi Kawano; Olivier Jordan; Takehisa Hanawa; Gerrit Borchard; Viorica Patrulea
Journal: Adv Wound Care (New Rochelle) Date: 2020-05-19 Impact factor: 4.730

Review 5. Chemical and Biological Characteristics of Antimicrobial α-Helical Peptides Found in Solitary Wasp Venoms and Their Interactions with Model Membranes.

Authors: Marcia Perez Dos Santos Cabrera; Marisa Rangel; João Ruggiero Neto; Katsuhiro Konno
Journal: Toxins (Basel) Date: 2019-09-24 Impact factor: 4.546

Antimicrobial peptide shows enhanced activity and reduced toxicity upon grafting to chitosan polymers.

1. Antimicrobial and antibiofilm activity of curcumin-silver nanoparticles with improved stability and selective toxicity to bacteria over mammalian cells.

2. Temperature-Controlled Reversible Exposure and Hiding of Antimicrobial Peptides on an Implant for Killing Bacteria at Room Temperature and Improving Biocompatibility in Vivo.

Review 3. Antimicrobial Peptides: Diversity, Mechanism of Action and Strategies to Improve the Activity and Biocompatibility In Vivo.

4. Are Antimicrobial Peptide Dendrimers an Escape from ESKAPE?

Review 5. Chemical and Biological Characteristics of Antimicrobial α-Helical Peptides Found in Solitary Wasp Venoms and Their Interactions with Model Membranes.

6. Stapled Anoplin as an Antibacterial Agent.

Review 7. Host Defense Peptides: Dual Antimicrobial and Immunomodulatory Action.

Review 8. Molecular engineering of antimicrobial peptide (AMP)-polymer conjugates.

Review 9. Advances in the Study of Structural Modification and Biological Activities of Anoplin.

10. A novel antimicrobial polymer efficiently treats multidrug-resistant MRSA-induced bloodstream infection.