Sha Wu1, Cheng Zhang1, Xi Zhang2, Ya-qi Xu1, Tian-xia Deng1. 1. Department of Hematology, Xinqiao Hospital, Third Military Medical University, Gaotantyan Street, Chongqing 400037, China. 2. Department of Hematology, Xinqiao Hospital, Third Military Medical University, Gaotantyan Street, Chongqing 400037, China. Electronic address: zhangxxi@sina.com.
Abstract
BACKGROUND: Peripheral-blood (PB) and bone marrow (BM) are both widely used in hematopoietic stem cell transplantation (HSCT). However, it has been controversial whether the use of PB or BM leads to a more favorable outcome of HSCT that involves unrelated HLA-matched donors. METHODS: We searched PubMed and Medline for relevant articles. Risk ratio (RR) and 95% confidence intervals (CIs) were calculated for statistical analyses. RESULTS: Twelve studies and 5589 patients were included in the assessment. The rate of engraftment (both neutrophil and platelet) was higher in the PBSCT group (RR=1.02, 95% CI=1.01-1.03, P=0.009; RR=1.18, 95% CI=1.00-1.41, P=0.05, RR=1.025, 95% CI=1.010-1.039, P=0.000; RR=1.031, 95% CI=1.012-1.051, P=0.002). In subgroup analyses, chronic GVHD and transplantation-related mortality were probably influenced by basic disease, conditioning. No significant statistical differences were found on the rate of relapse, 2-year overall survival (OS) and disease-free survival (DFS) after peripheral blood stem cell neither bone marrow transplantation (PBSCT and BMT). CONCLUSION: PBSC as a graft source shown more complete engraftment of neutrophil and platelet, but the decision to use either peripheral blood or bone marrow was made depended on the diagnosis, the conditioning regimen and the transplantation protocols.
BACKGROUND: Peripheral-blood (PB) and bone marrow (BM) are both widely used in hematopoietic stem cell transplantation (HSCT). However, it has been controversial whether the use of PB or BM leads to a more favorable outcome of HSCT that involves unrelated HLA-matched donors. METHODS: We searched PubMed and Medline for relevant articles. Risk ratio (RR) and 95% confidence intervals (CIs) were calculated for statistical analyses. RESULTS: Twelve studies and 5589 patients were included in the assessment. The rate of engraftment (both neutrophil and platelet) was higher in the PBSCT group (RR=1.02, 95% CI=1.01-1.03, P=0.009; RR=1.18, 95% CI=1.00-1.41, P=0.05, RR=1.025, 95% CI=1.010-1.039, P=0.000; RR=1.031, 95% CI=1.012-1.051, P=0.002). In subgroup analyses, chronic GVHD and transplantation-related mortality were probably influenced by basic disease, conditioning. No significant statistical differences were found on the rate of relapse, 2-year overall survival (OS) and disease-free survival (DFS) after peripheral blood stem cell neither bone marrow transplantation (PBSCT and BMT). CONCLUSION: PBSC as a graft source shown more complete engraftment of neutrophil and platelet, but the decision to use either peripheral blood or bone marrow was made depended on the diagnosis, the conditioning regimen and the transplantation protocols.
Authors: Mateja Kralj Juric; Sakhila Ghimire; Justyna Ogonek; Eva M Weissinger; Ernst Holler; Jon J van Rood; Machteld Oudshoorn; Anne Dickinson; Hildegard T Greinix Journal: Front Immunol Date: 2016-11-09 Impact factor: 7.561