Nicola R Swain1, Carmen C W Lim2, Daphna Levinson3, Fabian Fiestas4, Giovanni de Girolamo5, Jacek Moskalewicz6, Jean-Pierre Lepine7, Jose Posada-Villa8, Josep Maria Haro9, María Elena Medina-Mora10, Miguel Xavier11, Noboru Iwata12, Peter de Jonge13, Ronny Bruffaerts14, Siobhan O'Neill15, Ron C Kessler16, Kate M Scott2. 1. Department of Psychological Medicine, University of Otago, Dunedin, New Zealand. Electronic address: Nicola.swain@otago.ac.nz. 2. Department of Psychological Medicine, University of Otago, Dunedin, New Zealand. 3. Ministry of Health Israel, Mental Health Services, Israel. 4. Unit of Analysis and Generation of Evidence for Public Health, Peruvian National Institute of Health, Peru. 5. IRCCS Centro S. Giovanni di Dio Fatebenefratelli, Brescia, Italy. 6. Institute of Psychiatry and Neurology, Poland. 7. Assistance Publique Hôpitaux de Paris, Universités Paris Descartes - Paris Diderot Inserm UMR-S 1144, France. 8. Colegio Mayor de Cundinamarca University, Columbia. 9. Parc Sanitari Sant Joan de Déu, CIBERSAM, Universitat de Barcelona, Spain. 10. National Institute of Psychiatry Ramon de la Fuente, Mexico. 11. Chronic Diseases Research Center (CEDOC), Department of Mental Health, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Portugal. 12. Department of Clinical Psychology, Hiroshima International University, Japan. 13. University of Groningen, University Medical Center, Groningen Department of Psychiatry, Interdisciplinary Center, Psychopathology and Emotion regulation (ICPE), Groningen, The Netherlands. 14. University Psychiatric Centre, University of Leuven, Campus Gasthuisberg, Belgium. 15. School of Psychology, University of Ulster, Northern Ireland. 16. Department of Health Care Policy, Harvard Medical School, Boston, MA, United States.
Abstract
OBJECTIVES: To examine the associations between a wide range of mental disorders and subsequent onset of stroke. Lifecourse timing of stroke was examined using retrospectively reconstructed data from cross-sectional surveys. METHODS: Data from the World Mental Health Surveys were accessed. This data was collected from general population surveys over 17 countries of 87,250 adults. The Composite International Diagnostic Interview retrospectively assessed lifetime prevalence and age at onset of DSM-IV mental disorders. A weighted subsample (n=45,288), was used for analysis in the present study. Survival analyses estimated associations between first onset of mental disorders and subsequent stroke onset. RESULTS: Bivariate models showed that 12/16 mental disorders were associated with subsequent stroke onset (ORs ranging from 1.6 to 3.8). However, after adjustment for mental disorder comorbidity and smoking, only significant relationships between depression and stroke (OR 1.3) and alcohol abuse and stroke (OR 1.5) remained. Among females, having a bipolar disorder was also associated with increased stroke incidence (OR 2.1). Increasing number of mental disorders was associated with stroke onset in a dose-response fashion (OR 3.3 for 5+ disorders). CONCLUSIONS: Depression and alcohol abuse may have specific associations with incidence of non-fatal stroke. General severity of psychopathology may be a more important predictor of non-fatal stroke onset. Mental health treatment should be considered as part of stroke risk prevention. Limitations of retrospectively gathered cross sectional surveys design mean further research on the links between mental health and stroke incidence is warranted.
OBJECTIVES: To examine the associations between a wide range of mental disorders and subsequent onset of stroke. Lifecourse timing of stroke was examined using retrospectively reconstructed data from cross-sectional surveys. METHODS: Data from the World Mental Health Surveys were accessed. This data was collected from general population surveys over 17 countries of 87,250 adults. The Composite International Diagnostic Interview retrospectively assessed lifetime prevalence and age at onset of DSM-IV mental disorders. A weighted subsample (n=45,288), was used for analysis in the present study. Survival analyses estimated associations between first onset of mental disorders and subsequent stroke onset. RESULTS: Bivariate models showed that 12/16 mental disorders were associated with subsequent stroke onset (ORs ranging from 1.6 to 3.8). However, after adjustment for mental disorder comorbidity and smoking, only significant relationships between depression and stroke (OR 1.3) and alcohol abuse and stroke (OR 1.5) remained. Among females, having a bipolar disorder was also associated with increased stroke incidence (OR 2.1). Increasing number of mental disorders was associated with stroke onset in a dose-response fashion (OR 3.3 for 5+ disorders). CONCLUSIONS:Depression and alcohol abuse may have specific associations with incidence of non-fatal stroke. General severity of psychopathology may be a more important predictor of non-fatal stroke onset. Mental health treatment should be considered as part of stroke risk prevention. Limitations of retrospectively gathered cross sectional surveys design mean further research on the links between mental health and stroke incidence is warranted.
Authors: Yuji Okura; Lynn H Urban; Douglas W Mahoney; Steven J Jacobsen; Richard J Rodeheffer Journal: J Clin Epidemiol Date: 2004-10 Impact factor: 6.437
Authors: Silvia Koton; Andrea L C Schneider; Wayne D Rosamond; Eyal Shahar; Yingying Sang; Rebecca F Gottesman; Josef Coresh Journal: JAMA Date: 2014-07-16 Impact factor: 56.272
Authors: Dawn O Kleindorfer; Jane Khoury; Charles J Moomaw; Kathleen Alwell; Daniel Woo; Matthew L Flaherty; Pooja Khatri; Opeolu Adeoye; Simona Ferioli; Joseph P Broderick; Brett M Kissela Journal: Stroke Date: 2010-05-20 Impact factor: 7.914
Authors: Edward C Jauch; Jeffrey L Saver; Harold P Adams; Askiel Bruno; J J Buddy Connors; Bart M Demaerschalk; Pooja Khatri; Paul W McMullan; Adnan I Qureshi; Kenneth Rosenfield; Phillip A Scott; Debbie R Summers; David Z Wang; Max Wintermark; Howard Yonas Journal: Stroke Date: 2013-01-31 Impact factor: 7.914
Authors: Natalie C Momen; Oleguer Plana-Ripoll; Esben Agerbo; Michael E Benros; Anders D Børglum; Maria K Christensen; Søren Dalsgaard; Louisa Degenhardt; Peter de Jonge; Jean-Christophe P G Debost; Morten Fenger-Grøn; Jane M Gunn; Kim M Iburg; Lars V Kessing; Ronald C Kessler; Thomas M Laursen; Carmen C W Lim; Ole Mors; Preben B Mortensen; Katherine L Musliner; Merete Nordentoft; Carsten B Pedersen; Liselotte V Petersen; Anette R Ribe; Annelieke M Roest; Sukanta Saha; Andrew J Schork; Kate M Scott; Carson Sievert; Holger J Sørensen; Terry J Stedman; Mogens Vestergaard; Bjarni Vilhjalmsson; Thomas Werge; Nanna Weye; Harvey A Whiteford; Anders Prior; John J McGrath Journal: N Engl J Med Date: 2020-04-30 Impact factor: 91.245
Authors: Christoph U Correll; Marco Solmi; Nicola Veronese; Beatrice Bortolato; Stella Rosson; Paolo Santonastaso; Nita Thapa-Chhetri; Michele Fornaro; Davide Gallicchio; Enrico Collantoni; Giorgio Pigato; Angela Favaro; Francesco Monaco; Cristiano Kohler; Davy Vancampfort; Philip B Ward; Fiona Gaughran; André F Carvalho; Brendon Stubbs Journal: World Psychiatry Date: 2017-06 Impact factor: 49.548
Authors: A M Roest; P de Jonge; C W W Lim; D J Stein; A Al-Hamzawi; J Alonso; C Benjet; R Bruffaerts; B Bunting; J M Caldas-de-Almeida; M Ciutan; G de Girolamo; C Hu; D Levinson; Y Nakamura; F Navarro-Mateu; M Piazza; J Posada-Villa; Y Torres; B Wojtyniak; R C Kessler; K M Scott Journal: J Psychosom Res Date: 2017-03-24 Impact factor: 3.006
Authors: I H Heiberg; B K Jacobsen; L Balteskard; J G Bramness; Ø Naess; E Ystrom; T Reichborn-Kjennerud; C M Hultman; R Nesvåg; A Høye Journal: Acta Psychiatr Scand Date: 2019-03-29 Impact factor: 6.392
Authors: Amanda M Lambert; Helen M Parretti; Emma Pearce; Malcolm J Price; Mark Riley; Ronan Ryan; Natalie Tyldesley-Marshall; Tuba Saygın Avşar; Gemma Matthewman; Alexandra Lee; Khaled Ahmed; Maria Lisa Odland; Christoph U Correll; Marco Solmi; Tom Marshall Journal: PLoS Med Date: 2022-04-19 Impact factor: 11.613