S Bardak1, K Turgutalp2, M Türkegün3, S Demir2, A Kıykım2. 1. Division of Nephrology, Department of Internal Medicine, School of Medicine, Mersin University, Mersin, Turkey. Electronic address: bardaksimge@gmail.com. 2. Division of Nephrology, Department of Internal Medicine, School of Medicine, Mersin University, Mersin, Turkey. 3. Department of Biostatistics and Medical Informatics, School of Medicine, Mersin University, Mersin, Turkey.
Abstract
OBJECTIVE: Renal transplant patients may have recurrent episodes of acute kidney injury (AKI) during the posttransplant period. Determination and management of risk factors may help to prevent recurrence of AKI and allograft loss. In this study, we investigated the clinical features of renal transplant patients with recurrent AKI and evaluated etiologies and risk factors. MATERIALS AND METHODS: A total of 19 patients with 79 AKI episodes were examined retrospectively. AKI classes, etiologies, and risk factors were investigated. Their features were compared with 38 renal transplant patients without AKI. RESULTS: Distribution of AKI episodes according to the type of injury was as follows: 15 prerenal, 43 renal, 6 postrenal, and 15 mixed. Renal transplant patients with recurrent AKI had a greater duration of dialysis before transplantation (P < .05). Logistic regression analysis revealed no predictor for recurrent AKI after renal transplantation. Infections participated in the development of 45 AKI episodes. Chronic kidney disease developed in 16 patients. CONCLUSION: Infections are the leading condition associated with recurrent AKI in renal transplant patients. Recurrent AKI may contribute to the development and progression of chronic kidney injury.
OBJECTIVE:Renal transplantpatients may have recurrent episodes of acute kidney injury (AKI) during the posttransplant period. Determination and management of risk factors may help to prevent recurrence of AKI and allograft loss. In this study, we investigated the clinical features of renal transplantpatients with recurrent AKI and evaluated etiologies and risk factors. MATERIALS AND METHODS: A total of 19 patients with 79 AKI episodes were examined retrospectively. AKI classes, etiologies, and risk factors were investigated. Their features were compared with 38 renal transplantpatients without AKI. RESULTS: Distribution of AKI episodes according to the type of injury was as follows: 15 prerenal, 43 renal, 6 postrenal, and 15 mixed. Renal transplantpatients with recurrent AKI had a greater duration of dialysis before transplantation (P < .05). Logistic regression analysis revealed no predictor for recurrent AKI after renal transplantation. Infections participated in the development of 45 AKI episodes. Chronic kidney disease developed in 16 patients. CONCLUSION: Infections are the leading condition associated with recurrent AKI in renal transplantpatients. Recurrent AKI may contribute to the development and progression of chronic kidney injury.
Authors: Christine K Federspiel; Theis S Itenov; Kala Mehta; Raymond K Hsu; Morten H Bestle; Kathleen D Liu Journal: Ann Intensive Care Date: 2018-02-23 Impact factor: 6.925