I-Ju Chen1, Chia-Yu Liu1, Jung-Peng Chiu1, Chung-Hua Hsu2. 1. Branch of Linsen and Chinese Medicine, Taipei City Hospital, Taiwan; Taiwan International Traditional Chinese Medicine Training Center, Taipei, Taiwan; Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan. 2. Branch of Linsen and Chinese Medicine, Taipei City Hospital, Taiwan; Taiwan International Traditional Chinese Medicine Training Center, Taipei, Taiwan; Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address: owlherbs@yahoo.com.tw.
Abstract
BACKGROUND AND AIMS: To examine the effect and safety of high-dose green tea extract (Epigallocatechin gallate, EGCG) at a daily dosage of 856.8 mg on weight reduction and changes of lipid profile and obesity-related hormone peptides in women with central obesity. METHODS: We conducted a randomized, double-blind trial registered under ClinicalTrials.gov Identifier no. NCT02147041. A total of 115 women with central obesity were screened at our clinic. 102 of them with a body mass index (BMI) ≥ 27 kg/m(2) and a waist circumference (WC) ≥ 80 cm were eligible for the study. These women were randomly assigned to either a high-dose green tea group or placebo group. The total treatment time was 12 weeks. The main outcome measures were anthropometric measurements, lipid profiles, and obesity related hormone peptides including leptin, adiponectin, ghrelin, and insulin. RESULTS:Significant weight loss, from 76.8 ± 11.3 kg to 75.7 ± 11.5 kg (p = 0.025), as well as decreases in BMI (p = 0.018) and waist circumference (p = 0.023) were observed in the treatment group after 12 weeks of high-dose EGCG treatment. This study also demonstrated a consistent trend of decreased total cholesterol, reaching 5.33%, and decreased LDL plasma levels. There was good tolerance of the treatment among subjects without any side effects or adverse events. Significantly lower ghrelin levels and elevated adiponectin levels were detected in the study group than in the placebo group. CONCLUSION: 12 weeks of treatment with high-dose green tea extract resulted in significant weight loss, reduced waist circumference, and a consistent decrease in total cholesterol and LDL plasma levels without any side effects or adverse effects in women with central obesity. The antiobestic mechanism of high-dose green tea extract might be associated in part with ghrelin secretion inhibition, leading to increased adiponectin levels.
RCT Entities:
BACKGROUND AND AIMS: To examine the effect and safety of high-dose green tea extract (Epigallocatechin gallate, EGCG) at a daily dosage of 856.8 mg on weight reduction and changes of lipid profile and obesity-related hormone peptides in women with central obesity. METHODS: We conducted a randomized, double-blind trial registered under ClinicalTrials.gov Identifier no. NCT02147041. A total of 115 women with central obesity were screened at our clinic. 102 of them with a body mass index (BMI) ≥ 27 kg/m(2) and a waist circumference (WC) ≥ 80 cm were eligible for the study. These women were randomly assigned to either a high-dose green tea group or placebo group. The total treatment time was 12 weeks. The main outcome measures were anthropometric measurements, lipid profiles, and obesity related hormone peptides including leptin, adiponectin, ghrelin, and insulin. RESULTS: Significant weight loss, from 76.8 ± 11.3 kg to 75.7 ± 11.5 kg (p = 0.025), as well as decreases in BMI (p = 0.018) and waist circumference (p = 0.023) were observed in the treatment group after 12 weeks of high-dose EGCG treatment. This study also demonstrated a consistent trend of decreased total cholesterol, reaching 5.33%, and decreased LDL plasma levels. There was good tolerance of the treatment among subjects without any side effects or adverse events. Significantly lower ghrelin levels and elevated adiponectin levels were detected in the study group than in the placebo group. CONCLUSION: 12 weeks of treatment with high-dose green tea extract resulted in significant weight loss, reduced waist circumference, and a consistent decrease in total cholesterol and LDL plasma levels without any side effects or adverse effects in women with central obesity. The antiobestic mechanism of high-dose green tea extract might be associated in part with ghrelin secretion inhibition, leading to increased adiponectin levels.
Authors: Brian J Martin; Chris McGlory; Martin J MacInnis; Mary K Allison; Stuart M Phillips; Martin J Gibala Journal: J Appl Physiol (1985) Date: 2016-10-07
Authors: Piotr Olcha; Anna Winiarska-Mieczan; Małgorzata Kwiecień; Łukasz Nowakowski; Andrzej Miturski; Andrzej Semczuk; Bożena Kiczorowska; Krzysztof Gałczyński Journal: Int J Mol Sci Date: 2022-06-16 Impact factor: 6.208
Authors: Elizabeth X Zheng; Simona Rossi; Robert J Fontana; Raj Vuppalanchi; Jay H Hoofnagle; Ikhlas Khan; Victor J Navarro Journal: Drug Saf Date: 2016-08 Impact factor: 5.606
Authors: John A Batsis; John W Apolzan; Pamela J Bagley; Heather B Blunt; Vidita Divan; Sonia Gill; Angela Golden; Shalini Gundumraj; Steven B Heymsfield; Scott Kahan; Katherine Kopatsis; Ava Port; Elizabeth Prout Parks; Clifford A Reilly; Domenica Rubino; Katherine H Saunders; Ryan Shean; Luai Tabaza; Abishek Stanley; Beverly G Tchang; Shivani Gundumraj; Srividya Kidambi Journal: Obesity (Silver Spring) Date: 2021-07 Impact factor: 9.298