David A Lacher1, Jeffery P Hughes2. 1. National Center for Health Statistics, Centers for Disease Control and Prevention, 3311 Toledo Rd., Hyattsville, MD 20782, USA. Electronic address: dol2@cdc.gov. 2. National Center for Health Statistics, Centers for Disease Control and Prevention, 3311 Toledo Rd., Hyattsville, MD 20782, USA.
Abstract
BACKGROUND: Screening for prostate cancer using prostate-specific antigen (PSA) is common. Prostate cancer has been associated with higher total PSA (tPSA), lower free PSA (fPSA), lower percent free PSA (%fPSA), and higher complexed PSA (cPSA). METHODS: Total, free and complexed PSAs were performed on 3251 men ≥40years in the 2007-2010 National Health and Nutrition Examination Survey. Distributions of the PSA tests were examined by age, race and ethnicity, and body mass index (BMI) groups. Percentages of men at PSA thresholds were examined. RESULTS: Total PSA geometric mean was 0.96μg/l among men aged ≥40years and increased from 0.74μg/l for men 40-49years, to 1.82μg/l for men 80years and older. Non-Hispanic Whites had lower age-adjusted mean tPSA (1.03μg/l) and cPSA (0.56μg/l) than non-Hispanic Blacks (tPSA 1.25μg/l and cPSA 0.72μg/l). Obese men had lower age-adjusted mean total, free and complexed PSAs (0.94, 0.27, and 0.51μg/l, respectively) than men with normal BMI (tPSA 1.21, fPSA 0.32, and cPSA 0.68μg/l, respectively). CONCLUSION: Total, free and complexed PSAs increased with age; tPSA and cPSAs were highest in non-Hispanic Blacks; and total, free, and complexed PSAs were lowest in obese men. Published by Elsevier B.V.
BACKGROUND: Screening for prostate cancer using prostate-specific antigen (PSA) is common. Prostate cancer has been associated with higher total PSA (tPSA), lower free PSA (fPSA), lower percent free PSA (%fPSA), and higher complexed PSA (cPSA). METHODS: Total, free and complexed PSAs were performed on 3251 men ≥40years in the 2007-2010 National Health and Nutrition Examination Survey. Distributions of the PSA tests were examined by age, race and ethnicity, and body mass index (BMI) groups. Percentages of men at PSA thresholds were examined. RESULTS: Total PSA geometric mean was 0.96μg/l among men aged ≥40years and increased from 0.74μg/l for men 40-49years, to 1.82μg/l for men 80years and older. Non-Hispanic Whites had lower age-adjusted mean tPSA (1.03μg/l) and cPSA (0.56μg/l) than non-Hispanic Blacks (tPSA 1.25μg/l and cPSA 0.72μg/l). Obesemen had lower age-adjusted mean total, free and complexed PSAs (0.94, 0.27, and 0.51μg/l, respectively) than men with normal BMI (tPSA 1.21, fPSA 0.32, and cPSA 0.68μg/l, respectively). CONCLUSION: Total, free and complexed PSAs increased with age; tPSA and cPSAs were highest in non-Hispanic Blacks; and total, free, and complexed PSAs were lowest in obesemen. Published by Elsevier B.V.
Entities:
Keywords:
National health survey; Prostate cancer; Prostate-specific antigen
Authors: David M Werny; Trevor Thompson; Mona Saraiya; David Freedman; Benny J Kottiri; Robert R German; Mark Wener Journal: Cancer Epidemiol Biomarkers Prev Date: 2006-12-19 Impact factor: 4.254
Authors: Henrik Møller; Nina Roswall; Mieke Van Hemelrijck; Signe Benzon Larsen; Jack Cuzick; Lars Holmberg; Kim Overvad; Anne Tjønneland Journal: Int J Cancer Date: 2014-10-09 Impact factor: 7.396
Authors: W J Catalona; A W Partin; K M Slawin; M K Brawer; R C Flanigan; A Patel; J P Richie; J B deKernion; P C Walsh; P T Scardino; P H Lange; E N Subong; R E Parson; G H Gasior; K G Loveland; P C Southwick Journal: JAMA Date: 1998-05-20 Impact factor: 56.272
Authors: Luke E Pater; Kimberly W Hart; Brian J Blonigen; Christopher J Lindsell; William L Barrett Journal: Am J Clin Oncol Date: 2012-10 Impact factor: 2.339
Authors: R Jeffrey Karnes; F Roy MacKintosh; Christopher H Morrell; Lori Rawson; Preston C Sprenkle; Michael W Kattan; Michele Colicchia; Thomas B Neville Journal: Front Oncol Date: 2018-08-06 Impact factor: 6.244
Authors: Sean Harrison; Kate Tilling; Emma L Turner; Richard M Martin; Rosie Lennon; J Athene Lane; Jenny L Donovan; Freddie C Hamdy; David E Neal; J L H Ruud Bosch; Hayley E Jones Journal: Cancer Causes Control Date: 2020-03-11 Impact factor: 2.506