[Painful polyarticular syndrome probably induced by cyclosporin in three patients with a kidney transplant and one with a heart transplant].

Among others, ciclosporin had the advantage of decreasing appreciably the incidence of osteonecrosis after renal transplantation. However, the authors have isolated, in three renal transplant patients and one heart transplant patient, treated with ciclosporin, a new syndrome consisting of bilateral and symmetrical joint pain, affecting the lower extremities and lasting almost one year. Subsiding of the radiological aspect and the isotopic hyperfixation of the affected joints, at the end of the evolution, as well as the histological aspect of the bone surrounding the joints, remind somehow of algodystrophy. In both cases, the severity of the pain seemed to depend on the doses of ciclosporin, indicating that this molecule could play a role in the occurrence of this syndrome.