Literature DB >> 26090533

A practical fluorogenic substrate for high-throughput screening of glutathione S-transferase inhibitors.

Yuuta Fujikawa1, Fumika Morisaki, Asami Ogura, Kana Morohashi, Sora Enya, Ryusuke Niwa, Shinji Goto, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Hideshi Inoue.   

Abstract

We report a new fluorogenic substrate for glutathione S-transferase (GST), 3,4-DNADCF, enabling the assay with a low level of nonenzymatic background reaction. Inhibitors against Noppera-bo/GSTe14 from Drosophila melanogaster were identified by high throughput screening using 3,4-DNADCF, demonstrating the utility of this substrate.

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Year:  2015        PMID： 26090533     DOI： 10.1039/c5cc02067k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  7 in total

Review 1.  Optical substrates for drug-metabolizing enzymes: Recent advances and future perspectives.

Authors:  Qiang Jin; JingJing Wu; Yue Wu; Hongxin Li; Moshe Finel; Dandan Wang; Guangbo Ge
Journal:  Acta Pharm Sin B       Date:  2022-01-21       Impact factor: 14.903

2.  Non-steroidal inhibitors of Drosophila melanogaster steroidogenic glutathione S-transferase Noppera-bo.

Authors:  Kotaro Koiwai; Kana Morohashi; Kazue Inaba; Kana Ebihara; Hirotatsu Kojima; Takayoshi Okabe; Ryunosuke Yoshino; Takatsugu Hirokawa; Taiki Nampo; Yuuta Fujikawa; Hideshi Inoue; Fumiaki Yumoto; Toshiya Senda; Ryusuke Niwa
Journal:  J Pestic Sci       Date:  2021-02-20       Impact factor: 2.529

Review 3.  Transcriptional Regulators of Ecdysteroid Biosynthetic Enzymes and Their Roles in Insect Development.

Authors:  Takumi Kamiyama; Ryusuke Niwa
Journal:  Front Physiol       Date:  2022-02-08       Impact factor: 4.566

4.  Molecular action of larvicidal flavonoids on ecdysteroidogenic glutathione S-transferase Noppera-bo in Aedes aegypti.

Authors:  Kazue Inaba; Kana Ebihara; Miki Senda; Ryunosuke Yoshino; Chisako Sakuma; Kotaro Koiwai; Daisuke Takaya; Chiduru Watanabe; Akira Watanabe; Yusuke Kawashima; Kaori Fukuzawa; Riyo Imamura; Hirotatsu Kojima; Takayoshi Okabe; Nozomi Uemura; Shinji Kasai; Hirotaka Kanuka; Takashi Nishimura; Kodai Watanabe; Hideshi Inoue; Yuuta Fujikawa; Teruki Honma; Takatsugu Hirokawa; Toshiya Senda; Ryusuke Niwa
Journal:  BMC Biol       Date:  2022-02-17       Impact factor: 7.431

5.  A fluorophore's electron-deficiency does matter in designing high-performance near-infrared fluorescent probes.

Authors:  Xue-Xiang Zhang; Huan Qi; Ya-Lan Liu; Song-Qiu Yang; Peng Li; Yan Qiao; Pei-Yu Zhang; Shu-Hao Wen; Hai-Long Piao; Ke-Li Han
Journal:  Chem Sci       Date:  2020-09-21       Impact factor: 9.825

6.  Dual Roles of Glutathione in Ecdysone Biosynthesis and Antioxidant Function During Larval Development in Drosophila.

Authors:  Sora Enya; Chikana Yamamoto; Hajime Mizuno; Tsuyoshi Esaki; Hsin-Kuang Lin; Masatoshi Iga; Kana Morohashi; Yota Hirano; Hiroshi Kataoka; Tsutomu Masujima; Yuko Shimada-Niwa; Ryusuke Niwa
Journal:  Genetics       Date:  2017-10-11       Impact factor: 4.562

7.  An integrated approach to unravel a crucial structural property required for the function of the insect steroidogenic Halloween protein Noppera-bo.

Authors:  Kotaro Koiwai; Kazue Inaba; Kana Morohashi; Sora Enya; Reina Arai; Hirotatsu Kojima; Takayoshi Okabe; Yuuta Fujikawa; Hideshi Inoue; Ryunosuke Yoshino; Takatsugu Hirokawa; Koichiro Kato; Kaori Fukuzawa; Yuko Shimada-Niwa; Akira Nakamura; Fumiaki Yumoto; Toshiya Senda; Ryusuke Niwa
Journal:  J Biol Chem       Date:  2020-04-02       Impact factor: 5.157
  7 in total

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