Literature DB >> 26090270

The cryo-electron microscopy structure of γ-Secretase: towards complex assembly, substrate recognition and a catalytic mechanism.

Yanyong Kang1, Karsten Melcher1, H Eric Xu2.   

Abstract

Entities:  

Year:  2015        PMID： 26090270      PMCID： PMC4467836          DOI： 10.1093/nsr/nwu081

Source DB:  PubMed          Journal:  Natl Sci Rev        ISSN： 2053-714X            Impact factor:   17.275


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  7 in total

1.  Crystal structure of the γ-secretase component nicastrin.

Authors:  Tian Xie; Chuangye Yan; Rui Zhou; Yanyu Zhao; Linfeng Sun; Guanghui Yang; Peilong Lu; Dan Ma; Yigong Shi
Journal:  Proc Natl Acad Sci U S A       Date:  2014-09-02       Impact factor: 11.205

Review 2.  Learning by failing: ideas and concepts to tackle γ-secretases in Alzheimer's disease and beyond.

Authors:  Bart De Strooper; Lucía Chávez Gutiérrez
Journal:  Annu Rev Pharmacol Toxicol       Date:  2014-10-01       Impact factor: 13.820

Review 3.  Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease.

Authors:  Bart De Strooper
Journal:  EMBO Rep       Date:  2007-02       Impact factor: 8.807

4.  Dictyostelium possesses highly diverged presenilin/gamma-secretase that regulates growth and cell-fate specification and can accurately process human APP: a system for functional studies of the presenilin/gamma-secretase complex.

Authors:  Vanessa C McMains; Michael Myre; Lisa Kreppel; Alan R Kimmel
Journal:  Dis Model Mech       Date:  2010-08-10       Impact factor: 5.758

5.  Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution.

Authors:  Pamela Osenkowski; Hua Li; Wenjuan Ye; Dongyang Li; Lorene Aeschbach; Patrick C Fraering; Michael S Wolfe; Dennis J Selkoe; Huilin Li
Journal:  J Mol Biol       Date:  2008-11-05       Impact factor: 5.469

6.  Three-dimensional structure of human γ-secretase.

Authors:  Peilong Lu; Xiao-Chen Bai; Dan Ma; Tian Xie; Chuangye Yan; Linfeng Sun; Guanghui Yang; Yanyu Zhao; Rui Zhou; Sjors H W Scheres; Yigong Shi
Journal:  Nature       Date:  2014-06-29       Impact factor: 49.962

7.  Structure of the TRPV1 ion channel determined by electron cryo-microscopy.

Authors:  Maofu Liao; Erhu Cao; David Julius; Yifan Cheng
Journal:  Nature       Date:  2013-12-05       Impact factor: 49.962
  7 in total
  1 in total

1.  The Central Importance of Laboratories for Reducing Waste in Biomedical Research.

Authors:  Nikolas Stroth
Journal:  Sci Eng Ethics       Date:  2015-12-16       Impact factor: 3.525
  1 in total

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