Literature DB >> 26089353

HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers.

Rogier W Sanders1, Marit J van Gils2, Ronald Derking2, Devin Sok3, Thomas J Ketas4, Judith A Burger2, Gabriel Ozorowski5, Albert Cupo4, Cassandra Simonich6, Leslie Goo6, Heather Arendt7, Helen J Kim5, Jeong Hyun Lee5, Pavel Pugach4, Melissa Williams4, Gargi Debnath4, Brian Moldt3, Mariëlle J van Breemen2, Gözde Isik2, Max Medina-Ramírez2, Jaap Willem Back8, Wayne C Koff7, Jean-Philippe Julien5, Eva G Rakasz9, Michael S Seaman10, Miklos Guttman11, Kelly K Lee11, Per Johan Klasse4, Celia LaBranche12, William R Schief13, Ian A Wilson14, Julie Overbaugh6, Dennis R Burton15, Andrew B Ward5, David C Montefiori12, Hansi Dean7, John P Moore16.   

Abstract

A challenge for HIV-1 immunogen design is the difficulty of inducing neutralizing antibodies (NAbs) against neutralization-resistant (tier 2) viruses that dominate human transmissions. We show that a soluble recombinant HIV-1 envelope glycoprotein trimer that adopts a native conformation, BG505 SOSIP.664, induced NAbs potently against the sequence-matched tier 2 virus in rabbits and similar but weaker responses in macaques. The trimer also consistently induced cross-reactive NAbs against more sensitive (tier 1) viruses. Tier 2 NAbs recognized conformational epitopes that differed between animals and in some cases overlapped with those recognized by broadly neutralizing antibodies (bNAbs), whereas tier 1 responses targeted linear V3 epitopes. A second trimer, B41 SOSIP.664, also induced a strong autologous tier 2 NAb response in rabbits. Thus, native-like trimers represent a promising starting point for the development of HIV-1 vaccines aimed at inducing bNAbs.
Copyright © 2015, American Association for the Advancement of Science.

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Year:  2015        PMID： 26089353      PMCID： PMC4498988          DOI： 10.1126/science.aac4223

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  62 in total

1.  Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers.

Authors:  Claudia Blattner; Jeong Hyun Lee; Kwinten Sliepen; Ronald Derking; Emilia Falkowska; Alba Torrents de la Peña; Albert Cupo; Jean-Philippe Julien; Marit van Gils; Peter S Lee; Wenjie Peng; James C Paulson; Pascal Poignard; Dennis R Burton; John P Moore; Rogier W Sanders; Ian A Wilson; Andrew B Ward
Journal:  Immunity       Date:  2014-04-24       Impact factor: 31.745

2.  Envelope variants circulating as initial neutralization breadth developed in two HIV-infected subjects stimulate multiclade neutralizing antibodies in rabbits.

Authors:  Delphine C Malherbe; Franco Pissani; D Noah Sather; Biwei Guo; Shilpi Pandey; William F Sutton; Andrew B Stuart; Harlan Robins; Byung Park; Shelly J Krebs; Jason T Schuman; Spyros Kalams; Ann J Hessell; Nancy L Haigwood
Journal:  J Virol       Date:  2014-09-10       Impact factor: 5.103

3.  Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies.

Authors:  Nicole A Doria-Rose; Chaim A Schramm; Jason Gorman; Penny L Moore; Jinal N Bhiman; Brandon J DeKosky; Michael J Ernandes; Ivelin S Georgiev; Helen J Kim; Marie Pancera; Ryan P Staupe; Han R Altae-Tran; Robert T Bailer; Ema T Crooks; Albert Cupo; Aliaksandr Druz; Nigel J Garrett; Kam H Hoi; Rui Kong; Mark K Louder; Nancy S Longo; Krisha McKee; Molati Nonyane; Sijy O'Dell; Ryan S Roark; Rebecca S Rudicell; Stephen D Schmidt; Daniel J Sheward; Cinque Soto; Constantinos Kurt Wibmer; Yongping Yang; Zhenhai Zhang; James C Mullikin; James M Binley; Rogier W Sanders; Ian A Wilson; John P Moore; Andrew B Ward; George Georgiou; Carolyn Williamson; Salim S Abdool Karim; Lynn Morris; Peter D Kwong; Lawrence Shapiro; John R Mascola
Journal:  Nature       Date:  2014-03-02       Impact factor: 49.962

4.  Boosting of HIV-1 neutralizing antibody responses by a distally related retroviral envelope protein.

Authors:  Hannes Uchtenhagen; Torben Schiffner; Emma Bowles; Leo Heyndrickx; Celia LaBranche; Steven E Applequist; Marianne Jansson; Thushan De Silva; Jaap Willem Back; Adnane Achour; Gabriella Scarlatti; Anders Fomsgaard; David Montefiori; Guillaume Stewart-Jones; Anna-Lena Spetz
Journal:  J Immunol       Date:  2014-05-14       Impact factor: 5.422

5.  Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques.

Authors:  Masashi Shingai; Olivia K Donau; Ronald J Plishka; Alicia Buckler-White; John R Mascola; Gary J Nabel; Martha C Nason; David Montefiori; Brian Moldt; Pascal Poignard; Ron Diskin; Pamela J Bjorkman; Michael A Eckhaus; Florian Klein; Hugo Mouquet; Julio Cesar Cetrulo Lorenzi; Anna Gazumyan; Dennis R Burton; Michel C Nussenzweig; Malcolm A Martin; Yoshiaki Nishimura
Journal:  J Exp Med       Date:  2014-08-25       Impact factor: 14.307

6.  Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface.

Authors:  Jinghe Huang; Byong H Kang; Marie Pancera; Jeong Hyun Lee; Tommy Tong; Yu Feng; Hiromi Imamichi; Ivelin S Georgiev; Gwo-Yu Chuang; Aliaksandr Druz; Nicole A Doria-Rose; Leo Laub; Kwinten Sliepen; Marit J van Gils; Alba Torrents de la Peña; Ronald Derking; Per-Johan Klasse; Stephen A Migueles; Robert T Bailer; Munir Alam; Pavel Pugach; Barton F Haynes; Richard T Wyatt; Rogier W Sanders; James M Binley; Andrew B Ward; John R Mascola; Peter D Kwong; Mark Connors
Journal:  Nature       Date:  2014-09-03       Impact factor: 49.962

7.  Glycosylation and disulfide bond analysis of transiently and stably expressed clade C HIV-1 gp140 trimers in 293T cells identifies disulfide heterogeneity present in both proteins and differences in O-linked glycosylation.

Authors:  Eden P Go; David Hua; Heather Desaire
Journal:  J Proteome Res       Date:  2014-08-06       Impact factor: 4.466

8.  Structure and immune recognition of trimeric pre-fusion HIV-1 Env.

Authors:  Marie Pancera; Tongqing Zhou; Aliaksandr Druz; Ivelin S Georgiev; Cinque Soto; Jason Gorman; Jinghe Huang; Priyamvada Acharya; Gwo-Yu Chuang; Gilad Ofek; Guillaume B E Stewart-Jones; Jonathan Stuckey; Robert T Bailer; M Gordon Joyce; Mark K Louder; Nancy Tumba; Yongping Yang; Baoshan Zhang; Myron S Cohen; Barton F Haynes; John R Mascola; Lynn Morris; James B Munro; Scott C Blanchard; Walther Mothes; Mark Connors; Peter D Kwong
Journal:  Nature       Date:  2014-10-08       Impact factor: 49.962

9.  CD4-induced activation in a soluble HIV-1 Env trimer.

Authors:  Miklos Guttman; Natalie K Garcia; Albert Cupo; Tsutomu Matsui; Jean-Philippe Julien; Rogier W Sanders; Ian A Wilson; John P Moore; Kelly K Lee
Journal:  Structure       Date:  2014-06-12       Impact factor: 5.006

10.  Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits.

Authors:  Anila Yasmeen; Rajesh Ringe; Ronald Derking; Albert Cupo; Jean-Philippe Julien; Dennis R Burton; Andrew B Ward; Ian A Wilson; Rogier W Sanders; John P Moore; Per Johan Klasse
Journal:  Retrovirology       Date:  2014-05-29       Impact factor: 4.602
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  314 in total

1.  Range of CD4-Bound Conformations of HIV-1 gp120, as Defined Using Conditional CD4-Induced Antibodies.

Authors:  Gilad Kaplan; Anna Roitburd-Berman; George K Lewis; Jonathan M Gershoni
Journal:  J Virol       Date:  2016-04-14       Impact factor: 5.103

2.  Influences on the Design and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers.

Authors:  Rajesh P Ringe; Anila Yasmeen; Gabriel Ozorowski; Eden P Go; Laura K Pritchard; Miklos Guttman; Thomas A Ketas; Christopher A Cottrell; Ian A Wilson; Rogier W Sanders; Albert Cupo; Max Crispin; Kelly K Lee; Heather Desaire; Andrew B Ward; P J Klasse; John P Moore
Journal:  J Virol       Date:  2015-08-26       Impact factor: 5.103

3.  Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes.

Authors:  Steven W de Taeye; Gabriel Ozorowski; Alba Torrents de la Peña; Miklos Guttman; Jean-Philippe Julien; Tom L G M van den Kerkhof; Judith A Burger; Laura K Pritchard; Pavel Pugach; Anila Yasmeen; Jordan Crampton; Joyce Hu; Ilja Bontjer; Jonathan L Torres; Heather Arendt; Joanne DeStefano; Wayne C Koff; Hanneke Schuitemaker; Dirk Eggink; Ben Berkhout; Hansi Dean; Celia LaBranche; Shane Crotty; Max Crispin; David C Montefiori; P J Klasse; Kelly K Lee; John P Moore; Ian A Wilson; Andrew B Ward; Rogier W Sanders
Journal:  Cell       Date:  2015-12-17       Impact factor: 41.582

4.  SOS and IP Modifications Predominantly Affect the Yield but Not Other Properties of SOSIP.664 HIV-1 Env Glycoprotein Trimers.

Authors:  Rajesh P Ringe; Philippe Colin; Jonathan L Torres; Anila Yasmeen; Wen-Hsin Lee; Albert Cupo; Andrew B Ward; P J Klasse; John P Moore
Journal:  J Virol       Date:  2019-12-12       Impact factor: 5.103

Review 5.  New developments in an old strategy: heterologous vector primes and envelope protein boosts in HIV vaccine design.

Authors:  Thomas Musich; Marjorie Robert-Guroff
Journal:  Expert Rev Vaccines       Date:  2016-03-16       Impact factor: 5.217

6.  Effect of HIV-1 envelope cytoplasmic tail on adenovirus primed virus encoded virus-like particle immunizations.

Authors:  Anne-Marie C Andersson; Emeline Ragonnaud; Kelly E Seaton; Sheetal Sawant; Antonella Folgori; Stefano Colloca; Celia Labranche; David C Montefiori; Georgia D Tomaras; Peter J Holst
Journal:  Vaccine       Date:  2016-09-12       Impact factor: 3.641

7.  Adenosine deaminase-1 enhances germinal center formation and functional antibody responses to HIV-1 Envelope DNA and protein vaccines.

Authors:  Ebony Gary; Margaret O'Connor; Marita Chakhtoura; Virginie Tardif; Ogan K Kumova; Delphine C Malherbe; William F Sutton; Nancy L Haigwood; Michele A Kutzler; Elias K Haddad
Journal:  Vaccine       Date:  2020-04-10       Impact factor: 3.641

8.  Closing and Opening Holes in the Glycan Shield of HIV-1 Envelope Glycoprotein SOSIP Trimers Can Redirect the Neutralizing Antibody Response to the Newly Unmasked Epitopes.

Authors:  Rajesh P Ringe; Pavel Pugach; Christopher A Cottrell; Celia C LaBranche; Gemma E Seabright; Thomas J Ketas; Gabriel Ozorowski; Sonu Kumar; Anna Schorcht; Marit J van Gils; Max Crispin; David C Montefiori; Ian A Wilson; Andrew B Ward; Rogier W Sanders; P J Klasse; John P Moore
Journal:  J Virol       Date:  2019-02-05       Impact factor: 5.103

9.  Antibody responses to prime-boost vaccination with an HIV-1 gp145 envelope protein and chimpanzee adenovirus vectors expressing HIV-1 gp140.

Authors:  Kristel L Emmer; Lindsay Wieczorek; Steven Tuyishime; Sebastian Molnar; Victoria R Polonis; Hildegund C J Ertl
Journal:  AIDS       Date:  2016-10-23       Impact factor: 4.177

10.  Interdomain Stabilization Impairs CD4 Binding and Improves Immunogenicity of the HIV-1 Envelope Trimer.

Authors:  Peng Zhang; Jason Gorman; Hui Geng; Qingbo Liu; Yin Lin; Yaroslav Tsybovsky; Eden P Go; Barna Dey; Tsion Andine; Alice Kwon; Mit Patel; Deepali Gururani; Ferzan Uddin; Christina Guzzo; Raffaello Cimbro; Huiyi Miao; Krisha McKee; Gwo-Yu Chuang; Loïc Martin; Francesca Sironi; Mauro S Malnati; Heather Desaire; Edward A Berger; John R Mascola; Michael A Dolan; Peter D Kwong; Paolo Lusso
Journal:  Cell Host Microbe       Date:  2018-06-13       Impact factor: 21.023
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