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Literature DB >> 26088467

Covalent Incorporation of Trehalose within Hydrogels for Enhanced Long-Term Functional Stability and Controlled Release of Biomacromolecules.

Timothy M O'Shea^1,2, Matthew J Webber^2,3, Alex A Aimetti⁴, Robert Langer^1,2,5.

Abstract

Hydrogels with covalently incorporated trehalose are synthesized using thiol-ene Michael addition. Trehalose hydrogels afford prolonged stabilization and -controlled release of model enzymes in vitro and in vivo as well as preservation of protein stability under heat and -lyophilization stressors. Strong and -ordered hydrogen bonding interactions within covalently incorporated trehalose hydrogels represent a possible mechanism for protein stabilization.

Entities: Chemical Disease Gene Species

Keywords: drug delivery; hydrogels; pharmaceutical excipients; protein stability; trehalose

Mesh：

Substances：

Year: 2015 PMID： 26088467 PMCID： PMC4825875 DOI： 10.1002/adhm.201500334

Source DB: PubMed Journal: Adv Healthc Mater ISSN： 2192-2640 Impact factor: 9.933

45 in total

1. Protein instability and immunogenicity: roadblocks to clinical application of injectable protein delivery systems for sustained release.

Authors: Wim Jiskoot; Theodore W Randolph; David B Volkin; C Russell Middaugh; Christian Schöneich; Gerhard Winter; Wolfgang Friess; Daan J A Crommelin; John F Carpenter
Journal: J Pharm Sci Date: 2011-12-14 Impact factor: 3.534

2. Effect of body temperature on chondroitinase ABC's ability to cleave chondroitin sulfate glycosaminoglycans.

Authors: Nicole J Tester; Anna H Plaas; Dena R Howland
Journal: J Neurosci Res Date: 2007-04 Impact factor: 4.164

Review 3. Protein therapeutics: a summary and pharmacological classification.

Authors: Benjamin Leader; Quentin J Baca; David E Golan
Journal: Nat Rev Drug Discov Date: 2008-01 Impact factor: 84.694

4. Hydrogen bonding in maltooligomer-glycerol-water matrices: Relation to physical state and molecular free volume.

Authors: Mina Roussenova; Jean-Christophe Andrieux; M Ashraf Alam; Job Ubbink
Journal: Carbohydr Polym Date: 2013-12-11 Impact factor: 9.381

5. Preparation of molecularly imprinted polymers for the recognition of proteins via the generation of peptide-fragment binding sites by semi-covalent imprinting and enzymatic digestion.

Authors: Hironori Taguchi; Hirobumi Sunayama; Eri Takano; Yukiya Kitayama; Toshifumi Takeuchi
Journal: Analyst Date: 2015-01-28 Impact factor: 4.616

Review 6. PEG hydrogels for the controlled release of biomolecules in regenerative medicine.

Authors: Chien-Chi Lin; Kristi S Anseth
Journal: Pharm Res Date: 2008-12-18 Impact factor: 4.200

7. Trehalose glycopolymers as excipients for protein stabilization.

Authors: Juneyoung Lee; En-Wei Lin; Uland Y Lau; James L Hedrick; Erhan Bat; Heather D Maynard
Journal: Biomacromolecules Date: 2013-07-01 Impact factor: 6.988

8. Temperature scanning FTIR analysis of interactions between sugar and polymer additive in amorphous sugar-polymer mixtures.

Authors: Koreyoshi Imamura; Ken-Ichi Ohyama; Toru Yokoyama; Yoshinobu Maruyama; Hiroyuki Imanaka; Kazuhiro Nakanishi
Journal: J Pharm Sci Date: 2008-01 Impact factor: 3.534

Covalent Incorporation of Trehalose within Hydrogels for Enhanced Long-Term Functional Stability and Controlled Release of Biomacromolecules.

1. Protein instability and immunogenicity: roadblocks to clinical application of injectable protein delivery systems for sustained release.

2. Effect of body temperature on chondroitinase ABC's ability to cleave chondroitin sulfate glycosaminoglycans.

Review 3. Protein therapeutics: a summary and pharmacological classification.

4. Hydrogen bonding in maltooligomer-glycerol-water matrices: Relation to physical state and molecular free volume.

5. Preparation of molecularly imprinted polymers for the recognition of proteins via the generation of peptide-fragment binding sites by semi-covalent imprinting and enzymatic digestion.

Review 6. PEG hydrogels for the controlled release of biomolecules in regenerative medicine.

7. Trehalose glycopolymers as excipients for protein stabilization.

8. Temperature scanning FTIR analysis of interactions between sugar and polymer additive in amorphous sugar-polymer mixtures.

Review 9. Horseradish peroxidase: a modern view of a classic enzyme.

10. Multiple effects of trehalose on protein folding in vitro and in vivo.

1. Thiol-ene click hydrogels for therapeutic delivery.

2. Thermal stabilization of diverse biologics using reversible hydrogels.

Review 3. Synthesis and Application of Trehalose Materials.

Review 4. Biosynthetic Polymers as Functional Materials.