Amir Goren1, Chureen Carter2, Seina Lee2. 1. a Kantar Health , New York , NY , USA and. 2. b Janssen Scientific Affairs , LLC, Horsham , PA , USA.
Abstract
OBJECTIVE: The objective of this study is to compare health outcomes of patients using biologic therapies ustekinumab (UST) or adalimumab (ADA) for moderate-to-severe plaque psoriasis (PsO) and assess biologics non-adherence. METHODS: Two phases of web-based survey data were collected, assessing adult patients with PsO from a Diplomat® Specialty Pharmacy US claims database (Diplomat Specialty Pharmacy; Flint, MI). Measures included demographics, treatment and health characteristics/behaviors, treatment satisfaction, health-related quality of life (HRQoL), and productivity. Pooled and stratified (by biologics experience) bivariate and multivariable analyses were conducted. RESULTS: UST (n = 262) versus ADA (n = 83) users more frequently had psoriasis cleared (40.5% versus 15.4%, respectively, with no visible signs), better HRQoL as per Dermatology Life Quality Index (DLQI) score = 0 (45.2% versus 19.2%), and higher current effectiveness satisfaction, all p < 0.05. Adjusting for covariates, UST versus ADA bio-naïve patients (n = 68) had better (53.4% lower) DLQI scores, lower percent body surface affected (%BSA; 0.85 versus 1.43), more %BSA improvement (-1.60 versus -1.03), and lower activity impairment (90.4% lower), all p < 0.05. Non-adherence to UST (11.8%) versus ADA (32.5%) was lower, p < 0.05, and more access versus forgetfulness-related. However, no significant differences emerged on outcomes between overall or bio-experienced UST and ADA users. CONCLUSIONS: UST versus ADA PsO bio-naïve patients reported higher clearing rates, better DLQI, and lower activity impairment.
OBJECTIVE: The objective of this study is to compare health outcomes of patients using biologic therapies ustekinumab (UST) or adalimumab (ADA) for moderate-to-severe plaque psoriasis (PsO) and assess biologics non-adherence. METHODS: Two phases of web-based survey data were collected, assessing adult patients with PsO from a Diplomat® Specialty Pharmacy US claims database (Diplomat Specialty Pharmacy; Flint, MI). Measures included demographics, treatment and health characteristics/behaviors, treatment satisfaction, health-related quality of life (HRQoL), and productivity. Pooled and stratified (by biologics experience) bivariate and multivariable analyses were conducted. RESULTS:UST (n = 262) versus ADA (n = 83) users more frequently had psoriasis cleared (40.5% versus 15.4%, respectively, with no visible signs), better HRQoL as per Dermatology Life Quality Index (DLQI) score = 0 (45.2% versus 19.2%), and higher current effectiveness satisfaction, all p < 0.05. Adjusting for covariates, UST versus ADA bio-naïve patients (n = 68) had better (53.4% lower) DLQI scores, lower percent body surface affected (%BSA; 0.85 versus 1.43), more %BSA improvement (-1.60 versus -1.03), and lower activity impairment (90.4% lower), all p < 0.05. Non-adherence to UST (11.8%) versus ADA (32.5%) was lower, p < 0.05, and more access versus forgetfulness-related. However, no significant differences emerged on outcomes between overall or bio-experienced UST and ADA users. CONCLUSIONS:UST versus ADA PsO bio-naïve patients reported higher clearing rates, better DLQI, and lower activity impairment.
Entities:
Keywords:
Activity impairment; health-related quality of life; non-adherence; treatment satisfaction; work productivity
Authors: Ireny Y K Iskandar; Richard B Warren; Mark Lunt; Kayleigh J Mason; Ian Evans; Kathleen McElhone; Catherine H Smith; Nick J Reynolds; Darren M Ashcroft; Christopher E M Griffiths Journal: J Invest Dermatol Date: 2017-12-06 Impact factor: 7.590
Authors: Mwangi J Murage; Vanita Tongbram; Steven R Feldman; William N Malatestinic; Cynthia J Larmore; Talia M Muram; Russel T Burge; Charles Bay; Nicole Johnson; Sarah Clifford; Andre B Araujo Journal: Patient Prefer Adherence Date: 2018-08-21 Impact factor: 2.711