| Literature DB >> 26087412 |
Usama Ramadan Abdelmohsen1, Tanja Grkovic2, Srikkanth Balasubramanian3, Mohamed Salah Kamel4, Ronald J Quinn2, Ute Hentschel3.
Abstract
Genomic sequence data have revealed the presence of a large fraction of putatively silent biosynthetic gene clusters in the genomes of actinomycetes that encode for secondary metabolites, which are not detected under standard fermentation conditions. This review focuses on the effects of biological (co-cultivation), chemical, as well as molecular elicitation on secondary metabolism in actinomycetes. Our review covers the literature until June 2014 and exemplifies the diversity of natural products that have been recovered by such approaches from the phylum Actinobacteria.Keywords: Actinomycetes; Biological activities; Co-cultivation; Elicitation; Natural products; Silent gene clusters
Mesh:
Substances:
Year: 2015 PMID: 26087412 DOI: 10.1016/j.biotechadv.2015.06.003
Source DB: PubMed Journal: Biotechnol Adv ISSN: 0734-9750 Impact factor: 14.227