PURPOSE: We evaluated testicular morphology and spermatozoid parameters in spontaneously hypertensive rats treated with enalapril. MATERIALS AND METHODS: Spontaneously hypertensive rats were assigned to a hypertensive nontreated group and a hypertensive enalapril treated group. Wistar-Kyoto normotensive rats served as controls. Systolic blood pressure was measured weekly. Spermatozoid concentration, motility and viability were determined in samples collected from the epididymal tail. Testicular morphology was analyzed by morphometric methods. All data were compared using ANOVA and the Tukey post test with p <0.05 considered significant. RESULTS: Systolic blood pressure in the enalapril treated group was similar to that in controls but lower than in the nontreated group. Sperm concentration in the enalapril treated group was similar to that in controls and greater than in the nontreated group. Testicular vascular volumetric density decreased in the nontreated group while in enalapril treated rats this parameter was similar to that in controls. Volumetric density of the seminiferous epithelium in the enalapril treated group was higher than in the nontreated group and controls, indicating a possibly positive effect of enalapril on spermatogenesis. CONCLUSIONS: In this animal model hypertension caused morphological changes in the testis and upon spermatozoid production. Enalapril treatment partially protected the testicles from these alterations, restoring normal spermatozoid production.
PURPOSE: We evaluated testicular morphology and spermatozoid parameters in spontaneously hypertensiverats treated with enalapril. MATERIALS AND METHODS: Spontaneously hypertensiverats were assigned to a hypertensive nontreated group and a hypertensiveenalapril treated group. Wistar-Kyoto normotensive rats served as controls. Systolic blood pressure was measured weekly. Spermatozoid concentration, motility and viability were determined in samples collected from the epididymal tail. Testicular morphology was analyzed by morphometric methods. All data were compared using ANOVA and the Tukey post test with p <0.05 considered significant. RESULTS: Systolic blood pressure in the enalapril treated group was similar to that in controls but lower than in the nontreated group. Sperm concentration in the enalapril treated group was similar to that in controls and greater than in the nontreated group. Testicular vascular volumetric density decreased in the nontreated group while in enalapril treated rats this parameter was similar to that in controls. Volumetric density of the seminiferous epithelium in the enalapril treated group was higher than in the nontreated group and controls, indicating a possibly positive effect of enalapril on spermatogenesis. CONCLUSIONS: In this animal model hypertension caused morphological changes in the testis and upon spermatozoid production. Enalapril treatment partially protected the testicles from these alterations, restoring normal spermatozoid production.
Authors: Shobana Navaneethabalakrishnan; Bethany L Goodlett; Alexandra H Lopez; Joseph M Rutkowski; Brett M Mitchell Journal: Clin Sci (Lond) Date: 2020-12-23 Impact factor: 6.876
Authors: Lucas Giglio Colli; Larissa Berloffa Belardin; Cinthya Echem; Eliana Hiromi Akamine; Mariana Pereira Antoniassi; Rhayza Roberta Andretta; Lucas Solla Mathias; Stephen Fernandes de Paula Rodrigues; Ricardo Pimenta Bertolla; Maria Helena Catelli de Carvalho Journal: Sci Rep Date: 2019-07-30 Impact factor: 4.379
Authors: Antonio Simone Laganà; Salvatore Giovanni Vitale; Paola Iaconianni; Simona Gatti; Francesco Padula Journal: Int J Fertil Steril Date: 2016-09-05
Authors: Marcello H A Da Silva; Waldemar S Costa; Francisco J B Sampaio; Diogo B De Souza Journal: Asian J Androl Date: 2018 Sep-Oct Impact factor: 3.285