Asgerally T Fazleabas1, Andrea Braundmeier2, Kirstin Parkin3. 1. Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University College of Human Medicine, MI 48824, USA. Electronic address: asgi@hc.msu.edu. 2. Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, IL 62702, USA. 3. Department of Microbiology and Molecular Genetics, Michigan State University College of Human Medicine, MI 48824, USA.
Abstract
BACKGROUND: Endometriosis is a gynecological disorder that is associated with alterations in the immune system that contributes to its pathology as well as its associated infertility. MAIN FINDINGS: This brief report summarizes our findings related to the changes in T regulatory cells (Tregs) that may affect the uterine environment and impact the fertility of women and nonhuman primates with endometriosis. PRINCIPAL CONCLUSION: Targeted therapies that could reduce Tregs within the reproductive tract may have a potential as long-lasting or permanent contraception.
BACKGROUND:Endometriosis is a gynecological disorder that is associated with alterations in the immune system that contributes to its pathology as well as its associated infertility. MAIN FINDINGS: This brief report summarizes our findings related to the changes in T regulatory cells (Tregs) that may affect the uterine environment and impact the fertility of women and nonhuman primates with endometriosis. PRINCIPAL CONCLUSION: Targeted therapies that could reduce Tregs within the reproductive tract may have a potential as long-lasting or permanent contraception.
Authors: Natalia Karpovich; Petra Klemmt; Jung Hye Hwang; J Enda McVeigh; John K Heath; David H Barlow; Helen J Mardon Journal: J Clin Endocrinol Metab Date: 2004-12-21 Impact factor: 5.958
Authors: Ana Claudia Zenclussen; Katrin Gerlof; Maria Laura Zenclussen; André Sollwedel; Annarosa Zambon Bertoja; Thomas Ritter; Katja Kotsch; Joachim Leber; Hans-Dieter Volk Journal: Am J Pathol Date: 2005-03 Impact factor: 4.307