| Literature DB >> 26086179 |
Abstract
A new C-methylisoflavone, isosideroxylin (1), and a known C-methylflavone, sideroxylin (2), were isolated from the EtOAc extract of the leaves of Leiophyllum buxifolium. The two compounds were evaluated with the sulforhodamine B assay for their antiproliferative effects against ER(-) MDA-MB-231 and ER(+) MCF-7 breast cancer cell lines and the NIH3T3 mouse fibroblast cell line. Isosideroxylin (1) displayed a selective antiproliferative effect against MDA-MB-231 cells.Entities:
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Year: 2015 PMID： 26086179 DOI： 10.1021/acs.jnatprod.5b00100
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050