Kiran Pandey1, Ajay Bhagoliwal2, Sonal Jain1. 1. Department of Obstetrics and Gynecology, G.S.V.M. Medical College, Flat No. 104, Narayandeep Appt., 7/81, Tilaknagar, Kanpur, 208002 UP India. 2. Department of SPM, G.S.V.M. Medical College, Kanpur, UP India.
Abstract
OBJECTIVES: To study the diagnostic potential of optical imaging and its comparison with colposcopy, in detecting early cervical dysplasia. METHODS: The study was conducted on 200 patients attending the outdoor of UISE maternity hospital with symptoms suspicious of cervical lesions. All patients were subjected to colposcopy, followed by histo-pathological examination. Out of all HPE, 18 samples each from normal and dysplastic histology were sent to IIT Physics lab, Kanpur for optical imaging. Statistical analysis was done using sensitivity, specificity, PPV, and NPV. Chi square test was applied to calculate p value. RESULTS: In optical imaging, depolarization images had shown significant changes in the epithelium region of the dysplastic tissue as compared to normal one. It is found that the mean value of depolarization power for normal cervix tissues is less than 0.32, while for dysplastic tissues it is greater than 0.32. CONCLUSION: Optical imaging is fast, non-invasive tool with high sensitivity and specificity, comparable to colposcopy (sensitivity 88.9 vs 100 %, specificity 83.3 vs 86.6 %) and thus is useful in both for screening and diagnosis of cervical dysplasia.
OBJECTIVES: To study the diagnostic potential of optical imaging and its comparison with colposcopy, in detecting early cervical dysplasia. METHODS: The study was conducted on 200 patients attending the outdoor of UISE maternity hospital with symptoms suspicious of cervical lesions. All patients were subjected to colposcopy, followed by histo-pathological examination. Out of all HPE, 18 samples each from normal and dysplastic histology were sent to IIT Physics lab, Kanpur for optical imaging. Statistical analysis was done using sensitivity, specificity, PPV, and NPV. Chi square test was applied to calculate p value. RESULTS: In optical imaging, depolarization images had shown significant changes in the epithelium region of the dysplastic tissue as compared to normal one. It is found that the mean value of depolarization power for normal cervix tissues is less than 0.32, while for dysplastic tissues it is greater than 0.32. CONCLUSION: Optical imaging is fast, non-invasive tool with high sensitivity and specificity, comparable to colposcopy (sensitivity 88.9 vs 100 %, specificity 83.3 vs 86.6 %) and thus is useful in both for screening and diagnosis of cervical dysplasia.
Entities:
Keywords:
Cancer cervix; Colposcopy; Depolarization power; Optical imaging
Authors: Robert A Smith; Vilma Cokkinides; Durado Brooks; Debbie Saslow; Mona Shah; Otis W Brawley Journal: CA Cancer J Clin Date: 2011-01-04 Impact factor: 508.702