Literature DB >> 26084867

Menin-MLL inhibitors block oncogenic transformation by MLL-fusion proteins in a fusion partner-independent manner.

S He1, B Malik1, D Borkin1, H Miao1, S Shukla1, K Kempinska1, T Purohit1, J Wang1, L Chen1, B Parkin2, S N Malek2, G Danet-Desnoyers3, A G Muntean1, T Cierpicki1, J Grembecka1.   

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Year:  2015        PMID： 26084867      PMCID： PMC4830728          DOI： 10.1038/leu.2015.144

Source DB:  PubMed          Journal:  Leukemia        ISSN： 0887-6924            Impact factor:   11.528


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  15 in total

1.  Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias.

Authors:  Chi Wai So; Min Lin; Paul M Ayton; Everett H Chen; Michael L Cleary
Journal:  Cancer Cell       Date:  2003-08       Impact factor: 31.743

2.  MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome.

Authors:  Qian-Fei Wang; George Wu; Shuangli Mi; Fuhong He; Jun Wu; Jingfang Dong; Roger T Luo; Ryan Mattison; Joseph J Kaberlein; Shyam Prabhakar; Hongkai Ji; Michael J Thirman
Journal:  Blood       Date:  2011-04-25       Impact factor: 22.113

3.  MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.

Authors:  Kathrin M Bernt; Nan Zhu; Amit U Sinha; Sridhar Vempati; Joerg Faber; Andrei V Krivtsov; Zhaohui Feng; Natalie Punt; Amanda Daigle; Lars Bullinger; Roy M Pollock; Victoria M Richon; Andrew L Kung; Scott A Armstrong
Journal:  Cancer Cell       Date:  2011-07-12       Impact factor: 31.743

4.  MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia.

Authors:  Scott A Armstrong; Jane E Staunton; Lewis B Silverman; Rob Pieters; Monique L den Boer; Mark D Minden; Stephen E Sallan; Eric S Lander; Todd R Golub; Stanley J Korsmeyer
Journal:  Nat Genet       Date:  2001-12-03       Impact factor: 38.330

5.  Gene expression profiles of AML derived stem cells; similarity to hematopoietic stem cells.

Authors:  H Gal; N Amariglio; L Trakhtenbrot; J Jacob-Hirsh; O Margalit; A Avigdor; A Nagler; S Tavor; L Ein-Dor; T Lapidot; E Domany; G Rechavi; D Givol
Journal:  Leukemia       Date:  2006-10-12       Impact factor: 11.528

Review 6.  Mechanisms of leukemogenesis by MLL fusion proteins.

Authors:  Rolf Marschalek
Journal:  Br J Haematol       Date:  2010-12-01       Impact factor: 6.998

7.  Molecular basis of the mixed lineage leukemia-menin interaction: implications for targeting mixed lineage leukemias.

Authors:  Jolanta Grembecka; Amalia M Belcher; Thomas Hartley; Tomasz Cierpicki
Journal:  J Biol Chem       Date:  2010-10-20       Impact factor: 5.157

8.  The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis.

Authors:  Akihiko Yokoyama; Tim C P Somervaille; Kevin S Smith; Orit Rozenblatt-Rosen; Matthew Meyerson; Michael L Cleary
Journal:  Cell       Date:  2005-10-21       Impact factor: 41.582

9.  Chromosomal aberration of the 11q23 locus in acute leukemia and frequency of MLL gene translocation: results in 378 adult patients.

Authors:  M Christina Cox; Paola Panetta; Francesco Lo-Coco; Giovanni Del Poeta; Adriano Venditti; Luca Maurillo; M Ilaria Del Principe; Alessandro Mauriello; Lucia Anemona; Antonio Bruno; Carla Mazzone; Paolo Palombo; Sergio Amadori
Journal:  Am J Clin Pathol       Date:  2004-08       Impact factor: 2.493

Review 10.  The molecular biology of mixed lineage leukemia.

Authors:  Robert K Slany
Journal:  Haematologica       Date:  2009-06-16       Impact factor: 9.941
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  25 in total

Review 1.  Using genomics to define pediatric blood cancers and inform practice.

Authors:  Rachel E Rau; Mignon L Loh
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2018-11-30

2.  Pharmacologic Inhibition of the Menin-MLL Interaction Leads to Transcriptional Repression of PEG10 and Blocks Hepatocellular Carcinoma.

Authors:  Katarzyna Kempinska; Bhavna Malik; Dmitry Borkin; Szymon Klossowski; Shirish Shukla; Hongzhi Miao; Jingya Wang; Tomasz Cierpicki; Jolanta Grembecka
Journal:  Mol Cancer Ther       Date:  2017-11-15       Impact factor: 6.261

Review 3.  The genomics of acute myeloid leukemia in children.

Authors:  Shannon E Conneely; Rachel E Rau
Journal:  Cancer Metastasis Rev       Date:  2020-03       Impact factor: 9.264

Review 4.  Mixed-Lineage Leukemia Fusions and Chromatin in Leukemia.

Authors:  Andrei V Krivtsov; Takayuki Hoshii; Scott A Armstrong
Journal:  Cold Spring Harb Perspect Med       Date:  2017-11-01       Impact factor: 6.915

5.  Inhibition of microRNA-24 increases liver fibrosis by enhanced menin expression in Mdr2-/- mice.

Authors:  Chad Hall; Laurent Ehrlich; Fanyin Meng; Pietro Invernizzi; Francesca Bernuzzi; Terry C Lairmore; Gianfranco Alpini; Shannon Glaser
Journal:  J Surg Res       Date:  2017-05-11       Impact factor: 2.192

6.  Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction.

Authors:  Angelo Aguilar; Ke Zheng; Tianfeng Xu; Shilin Xu; Liyue Huang; Ester Fernandez-Salas; Liu Liu; Denzil Bernard; Kaitlin P Harvey; Caroline Foster; Donna McEachern; Jeanne Stuckey; Krishnapriya Chinnaswamy; James Delproposto; Jeff W Kampf; Shaomeng Wang
Journal:  J Med Chem       Date:  2019-06-22       Impact factor: 7.446

7.  Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL).

Authors:  Dmitry Borkin; Jonathan Pollock; Katarzyna Kempinska; Trupta Purohit; Xiaoqin Li; Bo Wen; Ting Zhao; Hongzhi Miao; Shirish Shukla; Miao He; Duxin Sun; Tomasz Cierpicki; Jolanta Grembecka
Journal:  J Med Chem       Date:  2016-01-25       Impact factor: 7.446

Review 8.  Therapeutic targeting potential of chromatin-associated proteins in MLL-rearranged acute leukemia.

Authors:  Xin Xu; Björn Schneider
Journal:  Cell Oncol (Dordr)       Date:  2018-11-16       Impact factor: 6.730

9.  Targeted therapy for fusion-driven high-risk acute leukemia.

Authors:  Yana Pikman; Kimberly Stegmaier
Journal:  Blood       Date:  2018-07-26       Impact factor: 22.113

10.  Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia.

Authors:  Szymon Klossowski; Hongzhi Miao; Katarzyna Kempinska; Tao Wu; Trupta Purohit; EunGi Kim; Brian M Linhares; Dong Chen; Gloria Jih; Eric Perkey; Huang Huang; Miao He; Bo Wen; Yi Wang; Ke Yu; Stanley Chun-Wei Lee; Gwenn Danet-Desnoyers; Winifred Trotman; Malathi Kandarpa; Anitria Cotton; Omar Abdel-Wahab; Hongwei Lei; Yali Dou; Monica Guzman; Luke Peterson; Tanja Gruber; Sarah Choi; Duxin Sun; Pingda Ren; Lian-Sheng Li; Yi Liu; Francis Burrows; Ivan Maillard; Tomasz Cierpicki; Jolanta Grembecka
Journal:  J Clin Invest       Date:  2020-02-03       Impact factor: 14.808
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