Literature DB >> 2608470

Solid-phase synthesis of oligoribonucleotides.

Y Z Xu1, C Lehmann, G Slim, C Christodoulou, Z K Tan, M J Gait.   

Abstract

An efficient method is described for solid-phase synthesis of oligoribonucleotides that involves use of the 9-fluorenylmethoxycarbonyl group (Fmoc) for 5'-protection, 4-methoxytetrahydropyran-4-yl (Mthp) for 2'-protection and a phosphoramidite coupling procedure.

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Year:  1989        PMID: 2608470

Source DB:  PubMed          Journal:  Nucleic Acids Symp Ser        ISSN: 0261-3166


  1 in total

1.  A general strategy for random insertion and substitution mutagenesis: substoichiometric coupling of trinucleotide phosphoramidites.

Authors:  J Sondek; D Shortle
Journal:  Proc Natl Acad Sci U S A       Date:  1992-04-15       Impact factor: 11.205

  1 in total

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