Literature DB >> 26084601

Upregulation of miR-107 Inhibits Glioma Angiogenesis and VEGF Expression.

Lei Chen1,2, Zong-yang Li2, Sui-yi Xu2, Xie-jun Zhang2, Yuan Zhang2, Kun Luo3, Wei-ping Li4,5.   

Abstract

MicroRNAs can function as oncogenes or tumor suppressors in glioma. Previously, we showed that miR-107 inhibits glioma cell proliferation, migration, and invasion. Since tumor growth and invasion are closely related to angiogenesis, we further examined the role of miR-107 in glioma angiogenesis. In a co-culture of glioma cells and human brain microvascular endothelial cells (HBMVEC), overexpression of miR-107 in glioma cells led to the inhibition of HBMVEC proliferation, migration, and tube formation ability. ELISA, RT-PCR, and western blot assays revealed that upregulation of miR-107 in glioma cells inhibits VEGF expression. Our findings collectively support the critical involvement of miR-107 in glioma cell angiogenesis and highlight its potential as a therapeutic target for glioma.

Entities:  

Keywords:  Angiogenesis; Glioma; HBMVEC; VEGF; miR-107

Mesh：

Substances：

Year:  2015        PMID： 26084601     DOI： 10.1007/s10571-015-0225-3

Source DB:  PubMed          Journal:  Cell Mol Neurobiol        ISSN： 0272-4340            Impact factor:   5.046


  29 in total

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Review 4.  Messenger RNA regulation: to translate or to degrade.

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Journal:  Cancer Treat Res       Date:  2015

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Authors:  Yu Ren; Xuan Zhou; Mei Mei; Xu-Bo Yuan; Lei Han; Guang-Xiu Wang; Zhi-Fan Jia; Peng Xu; Pei-Yu Pu; Chun-Sheng Kang
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Authors:  Zhu-mei Shi; Jing Wang; Zhiping Yan; Yong-ping You; Chong-yong Li; Xu Qian; Yu Yin; Peng Zhao; Ying-ying Wang; Xie-feng Wang; Ming-na Li; Ling-Zhi Liu; Ning Liu; Bing-Hua Jiang
Journal:  PLoS One       Date:  2012-03-19       Impact factor: 3.240
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  20 in total

1.  * Glioblastoma Exosomes for Therapeutic Angiogenesis in Peripheral Ischemia.

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Journal:  Tissue Eng Part A       Date:  2017-11       Impact factor: 3.845

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Journal:  Cardiovasc Res       Date:  2016-03-14       Impact factor: 10.787

3.  miR-373 Inhibits Glioma Cell U251 Migration and Invasion by Down-Regulating CD44 and TGFBR2.

Authors:  Furong Wei; Qianrong Wang; Qinghong Su; Haiyan Huang; Junwen Luan; Xiaoqun Xu; Junfu Wang
Journal:  Cell Mol Neurobiol       Date:  2016-02-08       Impact factor: 5.046

4.  The effects of CD147 on the cell proliferation, apoptosis, invasion, and angiogenesis in glioma.

Authors:  Haoyuan Yin; Ying Shao; Xuan Chen
Journal:  Neurol Sci       Date:  2016-10-19       Impact factor: 3.307

5.  LINC00152 acts as a potential marker in gliomas and promotes tumor proliferation and invasion through the LINC00152/miR-107/RAB10 axis.

Authors:  Gang Peng; Jun Su; Songhua Xiao; Qing Liu
Journal:  J Neurooncol       Date:  2021-09-03       Impact factor: 4.130

6.  MicroRNA-107 inhibits tumor growth and metastasis by targeting the BDNF-mediated PI3K/AKT pathway in human non-small lung cancer.

Authors:  Huan Xia; Yang Li; Xiaohong Lv
Journal:  Int J Oncol       Date:  2016-07-25       Impact factor: 5.650

7.  A 4-miRNA signature to predict survival in glioblastomas.

Authors:  Simon K Hermansen; Mia D Sørensen; Anker Hansen; Steen Knudsen; Alvaro G Alvarado; Justin D Lathia; Bjarne W Kristensen
Journal:  PLoS One       Date:  2017-11-14       Impact factor: 3.240

8.  MicroRNA-107-5p suppresses non-small cell lung cancer by directly targeting oncogene epidermal growth factor receptor.

Authors:  Ping Wang; Xiaomin Liu; Yang Shao; Huimin Wang; Chen Liang; Baohui Han; Zhongliang Ma
Journal:  Oncotarget       Date:  2017-06-16

9.  In vitro effect of microRNA-107 targeting Dkk-1 by regulation of Wnt/β-catenin signaling pathway in osteosarcoma.

Authors:  Zhi-Cai Zhang; Jian-Xiang Liu; Zeng-Wu Shao; Fei-Fei Pu; Bai-Chuan Wang; Qiang Wu; Yu-Kun Zhang; Xian-Lin Zeng; Xiao-Dong Guo; Shu-Hua Yang; Tong-Chuan He
Journal:  Medicine (Baltimore)       Date:  2017-07       Impact factor: 1.889

10.  Depleted tumor suppressor miR-107 in plasma relates to tumor progression and is a novel therapeutic target in pancreatic cancer.

Authors:  Taisuke Imamura; Shuhei Komatsu; Daisuke Ichikawa; Mahito Miyamae; Wataru Okajima; Takuma Ohashi; Jun Kiuchi; Keiji Nishibeppu; Hirotaka Konishi; Atsushi Shiozaki; Ryo Morimura; Hisashi Ikoma; Toshiya Ochiai; Kazuma Okamoto; Hiroki Taniguchi; Eigo Otsuji
Journal:  Sci Rep       Date:  2017-07-18       Impact factor: 4.379
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