Rehan Malik1, Ehimen C Aneni1, Sameer Shahrayar2, Wladimir M Freitas3, Shozab S Ali1,4, Emir Veledar1,5, Muhammad A Latif1, Muhammad Aziz1, Rameez Ahmed1, Sher A Khan1, Jeffrin Joseph1, Hamid Feiz2, Andrei Sposito3, Khurram Nasir6,7,8,9. 1. Center for Prevention and Wellness Research, Baptist Health South Florida, 1691 Michigan Avenue Suite 500; Miami Beach, Miami, FL, 33139, USA. 2. Aventura Hospital & Medical Center, Miami, FL, USA. 3. Cardiology Department, State University of Campinas School of Medicine, Campinas, 13084-971, Sao Paulo, Brazil. 4. University of Manchester School of Medicine, Manchester, UK. 5. Robert Stempel College of Public Health, Florida International University, Miami, FL, USA. 6. Center for Prevention and Wellness Research, Baptist Health South Florida, 1691 Michigan Avenue Suite 500; Miami Beach, Miami, FL, 33139, USA. KhurramN@baptisthealth.net. 7. Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University, Baltimore, MD, USA. KhurramN@baptisthealth.net. 8. Robert Stempel College of Public Health, Florida International University, Miami, FL, USA. KhurramN@baptisthealth.net. 9. Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA. KhurramN@baptisthealth.net.
Abstract
BACKGROUND: There is a limited data on the association between serum uric acid (SUA) and cardiovascular disease (CVD) among the very elderly population. AIMS: We evaluated the association of SUA, highly sensitive C-reactive protein (hs-CRP, a marker of vascular and systemic inflammation), and coronary artery calcification (CAC, a marker of subclinical CVD) in a cohort of Brazilian octogenarians (≥80 years) free from known clinical CVD. METHODS: 208 individuals were included and evaluated for an association between increasing tertiles of SUA, elevated hs-CRP (>3 mg/dL), the presence and burden of CAC (CAC > 0 and CAC > 400). RESULTS: The median hs-CRP was 1.9 (IQR = 1.0-3.4) mg/L and mean SUA was 5.3 (±1.4) mg/dL. The overall prevalence of elevated hs-CRP (>3 mg/dL) was 31 %. A significant increase in the prevalence of hs-CRP was noted across the higher SUA tertiles (p < 0.001) with 3.4 times the odds of having elevated hs-CRP in the highest SUA tertile (3.40; CI = 1.27-9.08). No association was noted with either the CAC presence and/or CAC burden (CAC > 0 or CAC > 400) across the increasing SUA tertiles. DISCUSSION: In the healthy octogenarians, higher SUA levels are associated with vascular inflammation (hs-CRP) but not with coronary atherosclerosis (CAC); markers for the subclinical CVD.
BACKGROUND: There is a limited data on the association between serum uric acid (SUA) and cardiovascular disease (CVD) among the very elderly population. AIMS: We evaluated the association of SUA, highly sensitive C-reactive protein (hs-CRP, a marker of vascular and systemic inflammation), and coronary artery calcification (CAC, a marker of subclinical CVD) in a cohort of Brazilian octogenarians (≥80 years) free from known clinical CVD. METHODS: 208 individuals were included and evaluated for an association between increasing tertiles of SUA, elevated hs-CRP (>3 mg/dL), the presence and burden of CAC (CAC > 0 and CAC > 400). RESULTS: The median hs-CRP was 1.9 (IQR = 1.0-3.4) mg/L and mean SUA was 5.3 (±1.4) mg/dL. The overall prevalence of elevated hs-CRP (>3 mg/dL) was 31 %. A significant increase in the prevalence of hs-CRP was noted across the higher SUA tertiles (p < 0.001) with 3.4 times the odds of having elevated hs-CRP in the highest SUA tertile (3.40; CI = 1.27-9.08). No association was noted with either the CAC presence and/or CAC burden (CAC > 0 or CAC > 400) across the increasing SUA tertiles. DISCUSSION: In the healthy octogenarians, higher SUA levels are associated with vascular inflammation (hs-CRP) but not with coronary atherosclerosis (CAC); markers for the subclinical CVD.
Entities:
Keywords:
CAC; Octogenarians; Subclinical CVD; hs-CRP and Serum Uric Acid
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