OBJECTIVE: To evaluate the association between objective short sleep duration in patients with insomnia and changes in blood parameters related to hypothalamic-pituitary-adrenal (HPA) axis activity. METHOD: A cross-sectional pilot study was conducted in 30 middle-aged adults with chronic insomnia who were divided into 2 groups according to polysomnography (PSG) total sleep time (TST) (TST > 5h and < 5h). All patients underwent subjective analysis of sleep quality, anthropometric measurements, PSG, and determination off asting blood parameters. RESULTS: The results revealed lower sleep efficiency and higher sleep latency for those with a TST < 5h. The subjective sleep quality was worse in the TST < 5h. Significantly, higher glucose and cortisol levels were observed with a TST < 5h. Glucose, cortisol and ACTH levels were inversely correlated with the PSG total sleep time. CONCLUSION: Patients with insomnia with objective short sleep duration had HPA-associated endocrine and metabolic imbalances chronically linked to increases in cardiovascular risk observed with this more severe insomnia phenotype.
OBJECTIVE: To evaluate the association between objective short sleep duration in patients with insomnia and changes in blood parameters related to hypothalamic-pituitary-adrenal (HPA) axis activity. METHOD: A cross-sectional pilot study was conducted in 30 middle-aged adults with chronic insomnia who were divided into 2 groups according to polysomnography (PSG) total sleep time (TST) (TST > 5h and < 5h). All patients underwent subjective analysis of sleep quality, anthropometric measurements, PSG, and determination off asting blood parameters. RESULTS: The results revealed lower sleep efficiency and higher sleep latency for those with a TST < 5h. The subjective sleep quality was worse in the TST < 5h. Significantly, higher glucose and cortisol levels were observed with a TST < 5h. Glucose, cortisol and ACTH levels were inversely correlated with the PSG total sleep time. CONCLUSION:Patients with insomnia with objective short sleep duration had HPA-associated endocrine and metabolic imbalances chronically linked to increases in cardiovascular risk observed with this more severe insomnia phenotype.
Authors: Suzanne M Bertisch; Benjamin D Pollock; Murray A Mittleman; Daniel J Buysse; Lydia A Bazzano; Daniel J Gottlieb; Susan Redline Journal: Sleep Date: 2018-06-01 Impact factor: 5.849
Authors: Denise C Jarrin; Hans Ivers; Manon Lamy; Ivy Y Chen; Allison G Harvey; Charles M Morin Journal: J Sleep Res Date: 2018-03-01 Impact factor: 3.981
Authors: Julio Fernandez-Mendoza; Fan He; Kristina Puzino; Gregory Amatrudo; Susan Calhoun; Duanping Liao; Alexandros N Vgontzas; Edward Bixler Journal: Sleep Date: 2021-01-21 Impact factor: 5.849
Authors: Evan A Winiger; Spencer B Huggett; Alexander S Hatoum; Naomi P Friedman; Christopher L Drake; Kenneth P Wright; John K Hewitt Journal: Sleep Date: 2020-05-12 Impact factor: 5.849