Correction: Comprehensive Analysis of Temporal Alterations in Cellular Proteome of Bacillus subtilis under Curcumin Treatment.

[This corrects the article DOI: 10.1371/journal.pone.0120620.].

S7 Fig is incorrect. Please view the correct S7 Fig below.

There are errors in Table 2. The values provided for Q-TOF data were inadvertently changed. Please see the corrected Table 2 here.

Table 2

Partial list of differentially expressed proteins in B. subtilis due to curcumin treatment obtained from iTRAQ analysis*

UniProt ID	Name of the protein	Gene name	Coverage	Uni. peptides(Orbitrap)	Fold change (Orbitrap)			Uni. peptides(Q-TOF)	Fold change (QTOF)
					20 min	60 min	120 min		20 min	60 min	120 min
Cell wall synthesis
P70965	UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1	MurAA	35.32	13	0.89	0.64	0.41	13	0.886	0.609	0.303
Q03522	UDP-N-acetylmuramoylalanine—D-glutamate ligase	MurD	31.04	13	0.98	0.67	0.47	4	1.145	0.979	0.824
P40778	UDP-N-acetylmuramate—L-alanine ligase	MurC	25.46	9	1.03	0.71	0.54	6	1.173	1.528	0.522
Q03523	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—2,6-diaminopimelate ligase	MurE	37.04	14	1.02	0.74	0.55	9	0.839	0.807	0.301
P37585	UDP-N-acetylglucosamine—N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase	MurG	37.47	11	0.91	0.8	0.63	3	0.671	0.678	0.402
P94556	Glutamate racemase 1	RacE	25.37	4	0.97	0.84	0.68	3	0.974	1.024	0.487
P96613	UDP-N-acetylmuramoyl-tripeptide—D-alanyl-D-alanine ligase	MurF	30.20	8	1.10	0.79	0.87	3	1.689	0.646	0.752
P0CI73	Glutamine—fructose-6-phosphate aminotransferase [isomerizing]	GlmS	30.33	15	0.92	0.79	0.53	10	0.931	0.751	0.396
P14192	Bifunctional protein GlmU	GlmU	23.03	8	0.93	0.83	0.58	7	1.397	0.916	0.819
Cell division and Sporulation
P45693	Stage V sporulation protein S	SpoVS	38.37	2	1.10	2.59	6.10	3	5.896	5.730	7.008
P28015	Putative septation protein SpoVG	SpoVG	42.27	4	0.96	1.51	4.49	2	0.955	0.713	2.268
Q07867	Cell division protein FtsL	FtsL	8.55	1	0.72	1.41	3.09	NI	NI	NI	NI
P0CI74	Cell cycle protein GpsB	GpsB	43.88	4	0.98	1.06	1.46	2	1.042	1.439	1.621
P06628	Sporulation initiation phosphotransferase F	SpoOF	23.39	2	0.79	1.75	2.93	2	0.570	1.782	2.644
Q01368	Stage III sporulation protein AB	SpoIIIAB	5.26	1	0.89	1.29	2.02	NI	NI	NI	NI
P06534	Stage 0 sporulation protein A	SpoOA	13.86	3	0.97	1.33	2.09	1			1.190
P71088	Sporulation-control protein spo0M	SpoOM	37.21	10	1.23	1.00	1.61	5	1.135	0.964	1.712
P39624	Spore coat polysaccharide biosynthesis protein SpsD	SpsD	4.84	1	0.97	0.43	1.13	NI	NI	NI	NI
P37470	Peptidyl-tRNA hydrolase	SpoVC	13.83	2	1.10	0.82	0.61	3	1.844	0.577	0.570
Fatty acid synthesis
O34746	3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 1	FabHA	45.83	13	1.01	0.56	0.38	6	1.048	0.578	0.414
O07600	3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2	FabHB	18.15	6	0.94	0.54	0.41	2	0.945	0.341	0.200
P71019	Malonyl CoA-acyl carrier protein transacylase	FabD	48.26	14	0.93	0.64	0.44	13	0.916	0.558	0.457
P54616	Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	FabI	51.16	11	0.91	0.65	0.54	5	0.999	0.741	0.648
O34340	3-oxoacyl-[acyl-carrier-protein] synthase 2	FabF	48.67	14	1.03	0.73	0.57	11	0.927	0.747	0.732
P51831	3-oxoacyl-[acyl-carrier-protein] reductase FabG	FabG	61.79	12	1.01	0.71	0.58	7	0.985	0.801	0.677
Stress response
P37571	Negative regulator of genetic competence ClpC/MecB	ClpC	59.88	45	1.20	1.65	2.43	28	1.102	1.546	1.998
P80244	ATP-dependent Clp protease proteolytic subunit	ClpP	43.15	8	1.09	2.07	2.26	4	1.168	1.639	2.352
P39778	ATP-dependent protease ATPase subunit ClpY	ClpY	35.55	14	1.17	1.41	1.82	5	1.552	1.520	2.026
O31673	ATP-dependent Clp protease ATP-binding subunit ClpE	ClpE	16.17	5	0.95	1.72	1.76	NI	NI	NI	NI
P39070	ATP-dependent protease subunit ClpQ	ClpQ	21.55	4	1.13	1.08	1.61	NI	NI	NI	NI
P54617	Phage shock protein A homolog	YdjF	58.59	11	0.76	1.22	3.09	6	1.062	1.549	2.386
P54375	Superoxide dismutase [Mn]	SodA	67.82	9	1.11	1.59	2.69	6	1.055	1.303	2.161
P42297	Universal stress protein YxiE	YxiE	45.27	5	1.19	0.95	2.34	3	0.907	0.880	1.397
P51777	Cold shock protein CspD	CspD	89.39	5	0.92	1.22	2.25	3	0.997	1.243	1.452
P28599	10 kDa chaperonin	GroS	73.40	7	1.09	1.82	2.20	5	1.148	1.651	2.493
P28598	60 kDa chaperonin	GroL	74.63	39	1.07	1.69	2.10	24	1.079	1.498	1.955
P39158	Cold shock protein CspC	CspC	59.09	5	0.22	0.82	1.86	1	0.181	0.832	1.756
P81100	Stress response protein SCP2	YceC	37.69	6	1.05	1.30	1.74	2	0.998	1.194	1.857
P54377	Probable glycine dehydrogenase [decarboxylating] subunit 2	GcvPB	9.43	3	1.20	2.15	1.67	1	0.698	2.985	2.562
O32221	Copper chaperone CopZ	CopZ	68.12	3	0.66	1.04	1.63	1		1.358	0.897
P15874	Protein GrpE	GrpE	57.75	10	0.96	1.13	1.51	4	1.710	1.716	1.163
P80875	General stress protein 16U	YceD	49.74	6	1.05	1.30	1.50	6	0.980	1.294	1.469
TCA cycle
P39120	Citrate synthase 2	CitZ	31.18	11	1.20	3.99	7.65	7	1.448	3.869	6.546
P09339	Aconitate hydratase	CitB	33.22	25	1.14	3.94	4.56	12	1.449	4.064	3.887
P39126	Isocitrate dehydrogenase [NADP]	Icd	44.21	20	1.10	3.06	3.53	9	1.003	3.302	2.885
P23129	2-oxoglutarate dehydrogenase E1 component	OdhA	35.28	27	1.37	2.90	1.96	14	1.113	1.911	1.634
P16263	Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex	OdhB	54.44	18	1.18	2.51	3.30	13	1.101	1.669	2.818
P80865	Succinyl-CoA ligase [ADP-forming] subunit alpha	SucD	33.00	6	1.12	2.73	3.39	4	2.458	2.642	3.074
P80886	Succinyl-CoA ligase [ADP-forming] subunit beta	SucC	55.32	22	1.11	3.26	4.08	14	1.185	3.907	3.806
P08065	Succinate dehydrogenase flavoprotein subunit	SdhA	49.32	22	1.44	2.40	2.06	9	1.279	1.914	2.462
P08066	Succinate dehydrogenase iron-sulfur subunit	SdhB	27.27	6	1.33	2.14	1.71	3	1.470	2.157	1.502
Nucleotide biosynthesis
P29726	Adenylosuccinate synthetase	PurA	26.05	10	1.12	0.76	0.55	6	1.569	0.736	1.302
P12047	Adenylosuccinate lyase	PurB	35.27	15	0.95	0.77	0.45	4	1.135	0.855	0.737
P12046	Phosphoribosylaminoimidazole-succinocarboxamide synthase	PurC	4.98	1	0.61	0.95	0.62	NI	NI	NI	NI
P12039	Phosphoribosylamine—glycine ligase	PurD	12.56	4	0.72	0.91	0.62	NI	NI	NI	NI
P12044	N5-carboxyaminoimidazole ribonucleotide mutase	PurE	19.75	2	0.81	1.02	0.57	2	0.762	0.747	1.097
P12048	Bifunctional purine biosynthesis protein PurH	PurH	27.54	11	0.66	0.98	0.56	5	0.597	1.050	0.384
P12042	Phosphoribosylformylglycinamidine synthase 2	PurL	3.10	2	0.55	0.82	0.53	NI	NI	NI	NI
P29727	GMP synthase [glutamine-hydrolyzing]	GuaA	58.67	27	1.03	0.64	0.42	16	1.074	0.652	0.493
O05269	GMP reductase	GuaC	48.16	10	1.06	1.00	0.49	4	1.495	0.572	0.608
P14193	Ribose-phosphate pyrophosphokinase	Prs	35.65	11	0.93	0.74	0.52	8	0.834	0.911	0.720

* This is a partial list having selected candidates; complete list is provided in supplementary table S2

# Only present in one replicates of iTRAQ data

NI- Not identified in Q-TOF

Quantitative profiles of the differentially expressed proteins (identified in iTRAQ-based quantitative proteomics analysis using Q-TOF) involved in diverse biological processes.

(TIF)

Click here for additional data file.