M Leroux1, C Desveaux2, M Parcevaux3, B Julliac4, J B Gouyon5, D Dallay6, J L Pellegrin7, M Boukerrou2, P Blanco7, E Lazaro7. 1. Department of Gynecology and Obstetrics, La Reunion University Hospital, Saint Pierre, France leroux_mel@yahoo.fr. 2. Department of Gynecology and Obstetrics, La Reunion University Hospital, Saint Pierre, France. 3. Department of Anesthesiology and Critical Care, Gabriel Martin Hospital, Saint Paul, France. 4. Department of Anesthesiology, CHU de Bordeaux, Bordeaux, France. 5. Department of Neonatology and NICU, La Reunion University Hospital, Saint Pierre, France. 6. Department of Gynecology and Obstetrics, CHU de Bordeaux, Bordeaux, France. 7. Department of Internal Medicine, CHU de Bordeaux, Bordeaux, France.
Abstract
OBJECTIVE: The aim of this study was to evaluate the effect of hydroxychloroquine (HCQ) on fetal preterm delivery and intrauterine growth restriction (IUGR) in a cohort of pregnant women with systemic lupus erythematosus (SLE). METHODS: Over an 11-year period (January 1, 2001 to December 31, 2011), all women with SLE and admitted to deliver after 22 weeks of gestation to Bordeaux University Hospital (France), were retrospectively enrolled in the present study. The population was then split into two groups based on the treatment they received: HCQ exposed (HCQ+) versus HCQ non-exposed (HCQ-) group. RESULTS: 118 pregnancies were included, 41 in the HCQ+ group and 77 in the HCQ- group. The rate of adverse fetal outcome was significantly lower in the HCQ+ group (p = 0.001), particularly in terms of preterm delivery, 15.8% versus 44.2% (p = 0.006), and IUGR, 10.5% versus 28.6% (p = 0.03). No adverse outcomes were reported in the HCQ+ group. CONCLUSION: HCQ reduces neonatal morbidity in women with SLE by significantly decreasing the rate of prematurity and intrauterine growth restriction.
OBJECTIVE: The aim of this study was to evaluate the effect of hydroxychloroquine (HCQ) on fetal preterm delivery and intrauterine growth restriction (IUGR) in a cohort of pregnant women with systemic lupus erythematosus (SLE). METHODS: Over an 11-year period (January 1, 2001 to December 31, 2011), all women with SLE and admitted to deliver after 22 weeks of gestation to Bordeaux University Hospital (France), were retrospectively enrolled in the present study. The population was then split into two groups based on the treatment they received: HCQ exposed (HCQ+) versus HCQ non-exposed (HCQ-) group. RESULTS: 118 pregnancies were included, 41 in the HCQ+ group and 77 in the HCQ- group. The rate of adverse fetal outcome was significantly lower in the HCQ+ group (p = 0.001), particularly in terms of preterm delivery, 15.8% versus 44.2% (p = 0.006), and IUGR, 10.5% versus 28.6% (p = 0.03). No adverse outcomes were reported in the HCQ+ group. CONCLUSION:HCQ reduces neonatal morbidity in women with SLE by significantly decreasing the rate of prematurity and intrauterine growth restriction.
Authors: Stephen J Balevic; Michael Cohen-Wolkowiez; Amanda M Eudy; Thomas P Green; Laura E Schanberg; Megan E B Clowse Journal: J Rheumatol Date: 2018-10-01 Impact factor: 4.666
Authors: Sylvia J Kroese; Carolien N H Abheiden; Birgit S Blomjous; Jacob M van Laar; Ronald W H M Derksen; Irene E M Bultink; Alexandre E Voskuyl; A Titia Lely; Marjon A de Boer; Johanna I P de Vries; Ruth D E Fritsch-Stork Journal: J Immunol Res Date: 2017-09-28 Impact factor: 4.818
Authors: S J Kroese; M J H de Hair; M Limper; A T Lely; J M van Laar; R H W M Derksen; R D E Fritsch-Stork Journal: J Immunol Res Date: 2017-12-17 Impact factor: 4.818