Noriyo Kimura1,2, Hideki Kimura3, Naoki Takahashi4, Toshihiko Hamada3, Hideki Maegawa5, Masaki Mori5, Yoshiaki Imamura5, Yukinori Kusaka6, Haruyoshi Yoshida7, Masayuki Iwano4. 1. Division of Nephrology, Department of General Medicine, University of Fukui, 23-3 Shimoaizuki, Matsuoka, Eiheiji-cho, Yoshida-gun, Fukui, 910-1193, Japan. nopoisute55@yahoo.co.jp. 2. Department of Internal Medicine, Fukui Kosei Hospital, Shimorokujyo-cho 201, Fukui, 918-8537, Japan. nopoisute55@yahoo.co.jp. 3. Department of Clinical Laboratoriesm, Fukui, Japan. 4. Division of Nephrology, Department of General Medicine, University of Fukui, 23-3 Shimoaizuki, Matsuoka, Eiheiji-cho, Yoshida-gun, Fukui, 910-1193, Japan. 5. Division of Surgical Pathology, University of Fukui Hospital, Fukui, Japan. 6. Department of Public Health, Faculty of Medical Sciences, University of Fukui, Fukui, Japan. 7. Sugita Genpaku Memorial Obama Municipal Hospital, Fukui, Japan.
Abstract
BACKGROUND: The renal resistive index (RI) is a Doppler-derived measure that reportedly correlates with renal histological changes and renal disease severity and outcome. The aim of this study was to investigate the factors related to the RI elevation in chronic kidney disease (CKD). METHODS: Using Doppler ultrasonography, RIs were determined in 30 patients with CKD, after which they were correlated with interstitial fibrosis, arteriosclerosis, arteriolosclerosis and peritubular capillary (PTC) density. PTC-positive areas were determined based on CD34 immunostaining. Interstitial fibrosis was detected with Masson trichrome staining. All histological markers were assessed using quantitative and semi-quantitative analyses and evaluated statistically using Pearson correlation tests, unpaired t tests and stepwise multiple regression analysis. RESULTS: RI correlated positively with age (r = 0.603, p = 0.0004), systolic blood pressure (r = 0.775, p < 0.0001), diastolic blood pressure (r = 0.575, p = 0.001), interstitial fibrosis (r = 0.381, p = 0.038) and arteriosclerosis (r = 0.520, p = 0.003), and negatively with creatinine clearance (r = -0.471, p = 0.009) and CD34+ (PTC) areas (r = -0.437, p = 0.016). Patients with hypertension or diabetes mellitus showed higher RIs (p < 0.05) than those without the ailments. Multivariate analysis showed PTC and arteriosclerosis to be independent variables correlating with RI (r (2) = 0.321, p < 0.05). CONCLUSIONS: To our knowledge, this is the first report of using RI measurements to evaluate peritubular capillary loss. Our findings indicate that increases in RI are associated with both arteriosclerosis and loss of PTCs.
BACKGROUND: The renal resistive index (RI) is a Doppler-derived measure that reportedly correlates with renal histological changes and renal disease severity and outcome. The aim of this study was to investigate the factors related to the RI elevation in chronic kidney disease (CKD). METHODS: Using Doppler ultrasonography, RIs were determined in 30 patients with CKD, after which they were correlated with interstitial fibrosis, arteriosclerosis, arteriolosclerosis and peritubular capillary (PTC) density. PTC-positive areas were determined based on CD34 immunostaining. Interstitial fibrosis was detected with Masson trichrome staining. All histological markers were assessed using quantitative and semi-quantitative analyses and evaluated statistically using Pearson correlation tests, unpaired t tests and stepwise multiple regression analysis. RESULTS: RI correlated positively with age (r = 0.603, p = 0.0004), systolic blood pressure (r = 0.775, p < 0.0001), diastolic blood pressure (r = 0.575, p = 0.001), interstitial fibrosis (r = 0.381, p = 0.038) and arteriosclerosis (r = 0.520, p = 0.003), and negatively with creatinine clearance (r = -0.471, p = 0.009) and CD34+ (PTC) areas (r = -0.437, p = 0.016). Patients with hypertension or diabetes mellitus showed higher RIs (p < 0.05) than those without the ailments. Multivariate analysis showed PTC and arteriosclerosis to be independent variables correlating with RI (r (2) = 0.321, p < 0.05). CONCLUSIONS: To our knowledge, this is the first report of using RI measurements to evaluate peritubular capillary loss. Our findings indicate that increases in RI are associated with both arteriosclerosis and loss of PTCs.
Entities:
Keywords:
Arteriosclerosis; Chronic kidney disease; Peritubular capillaries; Renal resistive index
Authors: Duk-Hee Kang; John Kanellis; Christian Hugo; Luan Truong; Sharon Anderson; Dontscho Kerjaschki; George F Schreiner; Richard J Johnson Journal: J Am Soc Nephrol Date: 2002-03 Impact factor: 10.121
Authors: Jörg Radermacher; Michael Mengel; Sebastian Ellis; Stephan Stuht; Markus Hiss; Anke Schwarz; Ute Eisenberger; Michael Burg; Friedrich C Luft; Wilfried Gwinner; Hermann Haller Journal: N Engl J Med Date: 2003-07-10 Impact factor: 91.245
Authors: M D Rifkin; L Needleman; M E Pasto; A B Kurtz; P M Foy; E McGlynn; C Canino; O H Baltarowich; R G Pennell; B B Goldberg Journal: AJR Am J Roentgenol Date: 1987-04 Impact factor: 3.959
Authors: Y Shimizu; T Itoh; H Hougaku; Y Nagai; H Hashimoto; M Sakaguchi; N Handa; K Kitagawa; M Matsumoto; M Hori Journal: Hypertens Res Date: 2001-01 Impact factor: 3.872
Authors: Elzbieta Florczak; Magdalena Januszewicz; Andrzej Januszewicz; Aleksander Prejbisz; Magdalena Kaczmarska; Ilona Michałowska; Marek Kabat; Tomasz Rywik; Dariusz Rynkun; Tomasz Zieliński; Beata Kuśmierczyk-Droszcz; Barbara Pregowska-Chwała; Grzegorz Kowalewski; Piotr Hoffman Journal: Blood Press Date: 2009 Impact factor: 2.835
Authors: Yang Gyun Kim; Ju-Young Moon; Bermseok Oh; Ho Jun Chin; Dong Ki Kim; Jung Hwan Park; Sung Joon Shin; Bum Soon Choi; Chun Soo Lim; Sang Ho Lee Journal: Front Cardiovasc Med Date: 2022-02-16