Literature DB >> 26081118

Toll like receptor-4 gene polymorphisms in patients with solitary cysticercus granuloma.

Akhilesh Singh1, Ravindra Kumar Garg2, Amita Jain3, Hardeep Singh Malhotra1, Shantanu Prakash3, Rajesh Verma1, Praveen Kumar Sharma1.   

Abstract

BACKGROUND: Solitary cysticercus granuloma (SCG) of the brain is the most common type of neurocysticercosis in India. In this study, we evaluated TLR4 polymorphisms in patients with SCG.
METHODS: One-hundred-forty-three patients with SCG and 134 controls were enrolled. Assessment for TLR4 Asp299Gly and Thr399Ile polymorphism was done. TLR4 genotype was determined by PCR-sequencing chain termination method. The patients were followed for 6 months.
RESULTS: Asp/Gly (P=0.024) and Thr/Ile (P=0.004) genotypes were significantly associated with the SCG. The Gly (Asp/Gly plus Gly/Gly) genotype (P=0.025) and Ile (Thr/Ile plus Ile/Ile) genotype (P=0.008) were significantly associated with the SCG. Gly/Gly and Ile/Ile genotypes were not significantly associated with SCG (P=0.767 for Gly/Gly, P=0.936 for Ile/Ile). At 6 months, TLR4 299Asp/Gly (P=0.02) and 399Ile/Thr (P=0.023) polymorphisms were significantly associated with the calcification or persistence of SCG.
CONCLUSIONS: TLR4 polymorphisms are associated with the susceptibility to infection with SCG.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Cysticercosis; Innate immunity; Neurocysticercosis; Ring enhancing lesion; Seizures; Toll-like receptors

Mesh：

Substances：

Year:  2015        PMID： 26081118     DOI： 10.1016/j.jns.2015.06.014

Source DB:  PubMed          Journal:  J Neurol Sci        ISSN： 0022-510X            Impact factor:   3.181


  4 in total

1.  The potential role of toll-like receptor 4 Asp299Gly polymorphism and its association with recurrent cystic echinococcosis in postoperative patients.

Authors:  Jafar Noori; Adel Spotin; Ehsan Ahmadpour; Mahmoud Mahami-Oskouei; Homayoun Sadeghi-Bazargani; Tohid Kazemi; Ebrahim Sakhinia; Leili Aghebati-Maleki; Firooz Shahrivar
Journal:  Parasitol Res       Date:  2018-03-30       Impact factor: 2.289

2.  Extraparenchymal neurocysticercosis: Demographic, clinicoradiological, and inflammatory features.

Authors:  Mariana Marcin Sierra; Mariana Arroyo; May Cadena Torres; Nancy Ramírez Cruz; Fernando García Hernández; Diana Taboada; Ángeles Galicia Martínez; Tzipe Govezensky; Edda Sciutto; Andrea Toledo; Agnès Fleury
Journal:  PLoS Negl Trop Dis       Date:  2017-06-09

3.  Toll-like Receptor-4 Polymorphisms and Serum Matrix Metalloproteinase-9 in Newly Diagnosed Patients With Calcified Neurocysticercosis and Seizures.

Authors:  Gaurav Lachuriya; Ravindra Kumar Garg; Amita Jain; Hardeep Singh Malhotra; Arvind Kumar Singh; Bhawna Jain; Neeraj Kumar; Rajesh Verma; Praveen Kumar Sharma
Journal:  Medicine (Baltimore)       Date:  2016-04       Impact factor: 1.889

Review 4.  Disseminated cysticercosis: clinical spectrum, Toll-like receptor-4 gene polymorphisms and role of albendazole: A prospective follow-up of 60 cases with a review of 56 published cases.

Authors:  Abdul Qavi; Ravindra Kumar Garg; Hardeep Singh Malhotra; Amita Jain; Neeraj Kumar; Kiran Preet Malhotra; Pradeep Kumar Srivastava; Rajesh Verma; Praveen Kumar Sharma
Journal:  Medicine (Baltimore)       Date:  2016-09       Impact factor: 1.889
  4 in total

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