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Literature DB >> 26080694

Interactions of 1D- and 2D-layered inorganic nanoparticles with fibroblasts and human mesenchymal stem cells.

Jason Thomas Rashkow¹, Yahfi Talukdar¹, Gaurav Lalwani¹, Balaji Sitharaman¹.

Abstract

AIM: This study investigates the effects of tungsten disulfide nanotubes (WSNTs) and molybdenum disulfide nanoplatelets (MSNPs) on fibroblasts (NIH-3T3) and mesenchymal stem cells (MSCs) to determine safe dosages for potential biomedical applications. MATERIALS &
METHODS: Cytotoxicity of MSNPs and WSNTs (5-300 μg/ml) on NIH-3T3 and MSCs was assessed at 6, 12 or 24 h. MSC differentiation to adipocytes and osteoblasts was assessed following treatment for 24 h.
RESULTS: Only NIH-3T3 cells treated with MSNPs showed dose or time dependent increase in cytotoxicity. Differentiation markers of MSCs in treated groups were unaffected compared with untreated controls.
CONCLUSION: MSNPs and WSNTs at concentrations less than 50 µg/ml are potentially safe for treatment of fibroblasts or MSCs for up to 24 h.

Entities: CellLine Chemical Disease Gene Species

Keywords: cytotoxicity; differentiation; inorganic nanoparticles; stem cells; tissue engineering; uptake

Mesh：

Substances：

Year: 2015 PMID： 26080694 PMCID： PMC4576357 DOI： 10.2217/nnm.15.35

Source DB: PubMed Journal: Nanomedicine (Lond) ISSN： 1743-5889 Impact factor: 5.307

32 in total

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