Michał Panek1, Tadeusz Pietras2, Andrzej Witusik3, Łukasz Wieteska4, Beata Małachowska5, Łukasz Mokros6, Wojciech Fendler7, Janusz Szemraj8, Piotr Kuna9. 1. Department of Internal Medicine, Asthma and Allergy, Medical University of Lodz, 22 Kopcinskiego Str., 90-153 Lodz, Poland. Electronic address: michalmp@poczta.onet.pl. 2. Department of Pneumology and Allergology, Medical University of Lodz, 22 Kopcinskiego Str., 90-153 Lodz, Poland. Electronic address: tadeusz.pietras@umed.lodz.pl. 3. Department of Psychology, The Jan Kochanowski University of Humanities and Sciences in Kielce, Branch in Piotrków Trybunalski, 114/118 Słowackiego Str., 97-300 Piotrków Trybunalski, Poland. Electronic address: awitusik@ujk.edu.pl. 4. Department of Medical Biochemistry, Medical University of Lodz, 6/8 Mazowiecka Str., Lodz 92-215, Poland. Electronic address: l.wieteska@yahoo.com. 5. Department of Pediatrics, Oncology, Hematology and Diabetology of Medical University of Lodz, 36/50 Sporna Str., Lodz 91-738, Poland. Electronic address: b.e.malachowska@gmail.com. 6. Department of Pneumology and Allergology, Medical University of Lodz, 22 Kopcinskiego Str., 90-153 Lodz, Poland; Students Research Group at the Department of Internal Medicine, Asthma and Allergy, Medical University of Lodz, 22 Kopcinskiego Str., 90-153 Lodz, Poland. Electronic address: sage.mkrs@gmail.com. 7. Department of Pediatrics, Oncology, Hematology and Diabetology of Medical University of Lodz, 36/50 Sporna Str., Lodz 91-738, Poland. Electronic address: wojciech.fendler@umed.lodz.pl. 8. Department of Medical Biochemistry, Medical University of Lodz, 6/8 Mazowiecka Str., Lodz 92-215, Poland. Electronic address: janusz.szemraj@umed.lodz.pl. 9. Department of Internal Medicine, Asthma and Allergy, Medical University of Lodz, 22 Kopcinskiego Str., 90-153 Lodz, Poland. Electronic address: piotr.kuna@umed.lodz.pl.
Abstract
Background: Personal and environmental factors might have an impact on strategies of coping with stress and temperamental traits according to the Regulative Theory of Temperament in asthmatic patients. They can modify the clinical picture, the course of a disease and effectiveness of treatment. Personal variables are key factors in determining formal characteristic of behavior and effective management method in asthmatic patients. Aim of study: The aim of the study was to identify selected personal and environmental factors, as well as factors inducing attacks and asthma exacerbations or maintaining them in a complex of personal traits of patients. Methods: Two hundred and eighty one participants were included in the study. Of this number 122 subjects were healthy volunteers and 159 were asthmatic patients. In all the subjects the authors applied the Formal Characteristic of Behaviour – FCZ-KT – Temperament Inventory, Coping Inventory for Stressful Situations (CISS), Beck Depression Inventory, State-Trait Anxiety Inventory and Borg Rating of Perceived Exertion (RPE) Scale. Genotyping of polymorphic forms of NR3C1 gene was conducted with PCR-RFLP and PCR-HRM methods. Expression of TGFβ1 gene was measured with the use of qRT-PCR. Results: The authors confirmed a significant influence of personal and environmental factors, such as: age, height, body weight, sex, asthma exacerbations, drugs administered by patients, allergy and psychopathological variables on strategies of coping with stress by asthmatic patients (Task-Oriented Coping, Emotion-Oriented Coping, Avoidance-Oriented Coping, distraction seeking, social diversion). Temperamental traits (Briskness, Perseverance, Sensory Sensitivity, Emotional Reactivity, Endurance, Activity) depend on age, sex, body weight, genetic predispositions and they are modified by asthma exacerbations, allergy, drugs administered by patients, depression and anxiety (state and trait). The authors confirmed a correlation between Tth111I polymorphic form of NR3C1 gene and perseverance (p= 0.0450). It was noted that an increase in the TGFβ1 expression level led to a decrease in the patients' emotional reactivity (p= 0.0212). Conclusions: Strategies of coping with stress and temperamental traits according to the Regulative Theory of Temperament in asthmatic patients are determined by personal and environmental factors.
Background: Personal and environmental factors might have an impact on strategies of coping with stress and temperamental traits according to the Regulative Theory of Temperament in asthmatic patients. They can modify the clinical picture, the course of a disease and effectiveness of treatment. Personal variables are key factors in determining formal characteristic of behavior and effective management method in asthmatic patients. Aim of study: The aim of the study was to identify selected personal and environmental factors, as well as factors inducing attacks and asthma exacerbations or maintaining them in a complex of personal traits of patients. Methods: Two hundred and eighty one participants were included in the study. Of this number 122 subjects were healthy volunteers and 159 were asthmatic patients. In all the subjects the authors applied the Formal Characteristic of Behaviour – FCZ-KT – Temperament Inventory, Coping Inventory for Stressful Situations (CISS), Beck Depression Inventory, State-Trait Anxiety Inventory and Borg Rating of Perceived Exertion (RPE) Scale. Genotyping of polymorphic forms of NR3C1 gene was conducted with PCR-RFLP and PCR-HRM methods. Expression of TGFβ1 gene was measured with the use of qRT-PCR. Results: The authors confirmed a significant influence of personal and environmental factors, such as: age, height, body weight, sex, asthma exacerbations, drugs administered by patients, allergy and psychopathological variables on strategies of coping with stress by asthmatic patients (Task-Oriented Coping, Emotion-Oriented Coping, Avoidance-Oriented Coping, distraction seeking, social diversion). Temperamental traits (Briskness, Perseverance, Sensory Sensitivity, Emotional Reactivity, Endurance, Activity) depend on age, sex, body weight, genetic predispositions and they are modified by asthma exacerbations, allergy, drugs administered by patients, depression and anxiety (state and trait). The authors confirmed a correlation between Tth111I polymorphic form of NR3C1 gene and perseverance (p= 0.0450). It was noted that an increase in the TGFβ1 expression level led to a decrease in the patients' emotional reactivity (p= 0.0212). Conclusions: Strategies of coping with stress and temperamental traits according to the Regulative Theory of Temperament in asthmatic patients are determined by personal and environmental factors.
Entities:
Keywords:
Anxiety; Depression; Dyspnea; NR3C1 gene; Personality traits (temperament); Strategies of coping with stress; TGfbeta1
Authors: Michał Panek; Mateusz Jonakowski; Jan Zioło; Tadeusz Pietras; Łukasz Wieteska; Beata Małachowska; Łukasz Mokros; Janusz Szemraj; Piotr Kuna Journal: Mol Neurobiol Date: 2016-02-13 Impact factor: 5.590
Authors: Andrzej Witusik; Łukasz Mokros; Piotr Kuna; Katarzyna Nowakowska-Domagała; Adam Antczak; Tadeusz Pietras Journal: Med Sci Monit Date: 2018-06-06
Authors: Andrzej Witusik; Łukasz Mokros; Marcin Kosmalski; Michał Panek; Katarzyna Nowakowska-Domagała; Kasper Sipowicz; Piotr Kuna; Tadeusz Pietras Journal: Postepy Dermatol Alergol Date: 2018-08-21 Impact factor: 1.837