Literature DB >> 2607969

Cloning and analysis of a deletable tetracycline-resistance determinant of Streptomyces lividans 1326.

A Kessler1, W Dittrich, M Betzler, H Schrempf.   

Abstract

An unstable determinant encoding resistance to tetracycline and minocycline has been cloned and characterized. It could be demonstrated that this determinant shares extensive homology with the otrA gene identified in Streptomyces rimosus. Tetracycline-sensitive variants of Streptomyces lividans derive mostly by deletion of this resistance determinant and neighbouring DNA regions.

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Year:  1989        PMID： 2607969     DOI： 10.1111/j.1365-2958.1989.tb00260.x

Source DB:  PubMed          Journal:  Mol Microbiol        ISSN： 0950-382X            Impact factor:   3.501


  4 in total

1.  Biosynthesis of antibiotics in streptomycetes.

Authors:  N D Lomovskaya; G V Sezonov
Journal:  World J Microbiol Biotechnol       Date:  1992-12       Impact factor: 3.312

2.  The synthesis of the Streptomyces reticuli cellulase (avicelase) is regulated by both activation and repression mechanisms.

Authors:  S Walter; H Schrempf
Journal:  Mol Gen Genet       Date:  1996-05-23

3.  The unstable tetracycline resistance gene of Streptomyces lividans 1326 encodes a putative protein with similarities to translational elongation factors and Tet(M) and Tet(O) proteins.

Authors:  W Dittrich; H Schrempf
Journal:  Antimicrob Agents Chemother       Date:  1992-05       Impact factor: 5.191

4.  A prokaryotic potassium ion channel with two predicted transmembrane segments from Streptomyces lividans.

Authors:  H Schrempf; O Schmidt; R Kümmerlen; S Hinnah; D Müller; M Betzler; T Steinkamp; R Wagner
Journal:  EMBO J       Date:  1995-11-01       Impact factor: 11.598
  4 in total

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