INTRODUCTION: Mild cognitive impairment (MCI) prodromic of vascular dementia is expected to have a multidomain profile. METHODS: In a sample of cerebral small vessel disease (SVD) patients, we assessed MCI subtypes distributions according to different operationalization of Winblad criteria and compared the neuroimaging features of single versus multidomain MCI. We applied three MCI diagnostic scenarios in which the cutoffs for objective impairment and the number of considered neuropsychological tests varied. RESULTS: Passing from a liberal to more conservative diagnostic scenarios, of 153 patients, 5% were no longer classified as MCI, amnestic multidomain frequency decreased, and nonamnestic single domain increased. Considering neuroimaging features, severe medial temporal lobe atrophy was more frequent in multidomain compared with single domain. DISCUSSION: Operationalizing MCI criteria changes the relative frequency of MCI subtypes. Nonamnestic single domain MCI may be a previously nonrecognized type of MCI associated with SVD.
INTRODUCTION: Mild cognitive impairment (MCI) prodromic of vascular dementia is expected to have a multidomain profile. METHODS: In a sample of cerebral small vessel disease (SVD) patients, we assessed MCI subtypes distributions according to different operationalization of Winblad criteria and compared the neuroimaging features of single versus multidomain MCI. We applied three MCI diagnostic scenarios in which the cutoffs for objective impairment and the number of considered neuropsychological tests varied. RESULTS: Passing from a liberal to more conservative diagnostic scenarios, of 153 patients, 5% were no longer classified as MCI, amnestic multidomain frequency decreased, and nonamnestic single domain increased. Considering neuroimaging features, severe medial temporal lobe atrophy was more frequent in multidomain compared with single domain. DISCUSSION: Operationalizing MCI criteria changes the relative frequency of MCI subtypes. Nonamnestic single domain MCI may be a previously nonrecognized type of MCI associated with SVD.
Authors: Eric E Smith; Alicja Cieslak; Philip Barber; Jerry Chen; Yu-Wei Chen; Ida Donnini; Jodi D Edwards; Richard Frayne; Thalia S Field; Janka Hegedus; Victoria Hanganu; Zahinoor Ismail; Jamila Kanji; Makoto Nakajima; Raza Noor; Stefano Peca; Demetrios Sahlas; Mukul Sharma; Luciano A Sposato; Richard H Swartz; Charlotte Zerna; Sandra E Black; Vladimir Hachinski Journal: J Am Heart Assoc Date: 2017-05-05 Impact factor: 5.501
Authors: Anders Wallin; Gustavo C Román; Margaret Esiri; Petronella Kettunen; Johan Svensson; George P Paraskevas; Elisabeth Kapaki Journal: J Alzheimers Dis Date: 2018 Impact factor: 4.472
Authors: Emilia Salvadori; Anna Poggesi; Giovanni Pracucci; Alberto Chiti; Laura Ciolli; Mirco Cosottini; Alessandra Del Bene; Nicola De Stefano; Stefano Diciotti; Ilaria Di Donato; Andrea Ginestroni; Sandro Marini; Mario Mascalchi; Serena Nannucci; Giovanni Orlandi; Marco Pasi; Francesca Pescini; Raffaella Valenti; Antonio Federico; Maria Teresa Dotti; Ubaldo Bonuccelli; Domenico Inzitari; Leonardo Pantoni Journal: Dement Geriatr Cogn Dis Extra Date: 2018-03-29