Umi Fahmida1, Min Kyaw Htet2, Chris Adhiyanto3, Risatianti Kolopaking4, Miza Agria Yudisti5, Allay Maududi5, Dwi Anita Suryandari6, Drupadi Dillon5,7, Lydia Afman8, Michael Müller9. 1. Southeast Asian Minister of Education Organization Regional Center for Food and Nutrition (SEAMEO RECFON), Universitas Indonesia, Jakarta, Indonesia. Email: umifahmida@gmail.com. 2. Center of Community Health and Population Studies, the Research Institute, Trisakti University, Jakarta, Indonesia. 3. Faculty of Medicine and Health Sciences, Universitas Islam Negeri Syarif Hidayatullah, Jakarta, Indonesia. 4. Faculty of Psychology, Universitas Islam Negeri Syarif Hidayatullah, Jakarta, Indonesia. 5. Southeast Asian Minister of Education Organization Regional Center for Food and Nutrition (SEAMEO RECFON), Universitas Indonesia, Jakarta, Indonesia. 6. Department of Biological Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia. 7. Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia. 8. Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, The Netherlands. 9. Nutrition, Metabolism and Genomics Group, Department of Human Nutrition, Wageningen University, The Netherlands.
Abstract
BACKGROUND/AIMS: Long-chain polyunsaturated fatty acids (LC-PUFA) are regarded as essential for child cognition. Genetic variation in fatty acid (FA) desaturase enzyme (FADS) has been recognized as an important effect modifier in the relation between LC-PUFA and child cognitive function. This study aimed to identify the distribution of genetic variant (genotype) SNP rs174468 and to assess plasma FA and developmental outcome by the genotype among under-2 year old Sasaknese Indonesian children. METHODS: Data was collected at baseline of a randomized trial (NUPICO, clinicaltrials.gov NCT01504633) in East Lombok district, Indonesia. Breastfed, 12- 17 month old children were recruited and 240 subjects were included in the study. Child cognition was assessed as Bayley Mental Developmental Index (MDI). RESULTS: From 206 subjects whose blood samples can be collected, only two genotypes were found (90.3% GG homozygotes, 9.7% AG heterozygotes), and minor allele AG was significantly associated with higher level of arachidonic acid (20:4 n-6), n-6 LC-PUFA and FADS1 index. MDI score was associated with a FADS2 index (DHA:EPA ratio) but not genotype (Adjusted R-square= 0.043). CONCLUSIONS:FADS2 index was associated with cognitive function. No difference was found between children with GG and AG genotypes who were all breastfed and not low birth weight.
RCT Entities:
BACKGROUND/AIMS: Long-chain polyunsaturated fatty acids (LC-PUFA) are regarded as essential for child cognition. Genetic variation in fatty acid (FA) desaturase enzyme (FADS) has been recognized as an important effect modifier in the relation between LC-PUFA and child cognitive function. This study aimed to identify the distribution of genetic variant (genotype) SNP rs174468 and to assess plasma FA and developmental outcome by the genotype among under-2 year old Sasaknese Indonesian children. METHODS: Data was collected at baseline of a randomized trial (NUPICO, clinicaltrials.gov NCT01504633) in East Lombok district, Indonesia. Breastfed, 12- 17 month old children were recruited and 240 subjects were included in the study. Child cognition was assessed as Bayley Mental Developmental Index (MDI). RESULTS: From 206 subjects whose blood samples can be collected, only two genotypes were found (90.3% GG homozygotes, 9.7% AG heterozygotes), and minor allele AG was significantly associated with higher level of arachidonic acid (20:4 n-6), n-6 LC-PUFA and FADS1 index. MDI score was associated with a FADS2 index (DHA:EPA ratio) but not genotype (Adjusted R-square= 0.043). CONCLUSIONS:FADS2 index was associated with cognitive function. No difference was found between children with GG and AG genotypes who were all breastfed and not low birth weight.
Authors: Jonathan Y Bernard; Hong Pan; Izzuddin M Aris; Margarita Moreno-Betancur; Shu-E Soh; Fabian Yap; Kok Hian Tan; Lynette P Shek; Yap-Seng Chong; Peter D Gluckman; Philip C Calder; Keith M Godfrey; Mary Foong-Fong Chong; Michael S Kramer; Neerja Karnani; Yung Seng Lee Journal: Am J Clin Nutr Date: 2018-07-01 Impact factor: 7.045
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