Emilia Janska1,2, Barbara Mohr3, Gerhard Wahl2. 1. Department of Stomatology and Maxillofacial Surgery, Comenius University, Bratislava, Slovak Republic. 2. Department of Oral Surgery, University Hospital Bonn, Welschnonnenstraße 17, 53111, Bonn, Germany. 3. Department of Oral Surgery, University Hospital Bonn, Welschnonnenstraße 17, 53111, Bonn, Germany. barbara.mohr@ukb.uni-bonn.de.
Abstract
OBJECTIVES: The rapidly increasing numbers of inserted dental implants and the growing incidence of peri-implant mucositis and peri-implantitis with the current absence of reliable disease risk prediction highlight the importance of early and sensitive diagnosis of possible disease progression. The aim of this study is to assess quantitative and qualitative analysis of peri-implant sulcular fluid (PISF) during implant maintenance control and to identify whether there is a positive correlation and statistical significance between peri-implant sulcular fluid volume results and collagenase2 level obtained from both superficial and fundus area of peri-implant sulcus. MATERIAL AND METHOD: Twenty-seven implants from patients under recall provided peri-implant sulcular fluid volume samples, which were collected with the Periotron 8000 micro-moisture meter, and collagenase2 levels, which were assessed using dentoTest aMMP8. Statistical analysis was obtained using Spearman's correlation. RESULTS: Positive correlation was found between collagenase2 collected from sulcular and fundus areas on both mesial and distal sides. There was correlation between peri-implant sulcular fluid volume and collagenase2 level from fundus and distal area, but not from the mesial and superficial area. CONCLUSIONS: Examination of collagenase2 is a sensitive method when examining early inflammatory changes but depends from the depth of the sample collection in the gingival pocket. CLINICAL RELEVANCE: The examination of MMP8 seems to be a more sensitive method than the analysis of peri-implant sulcular fluid to detect peri-implant mucositis and peri-implantitis.
OBJECTIVES: The rapidly increasing numbers of inserted dental implants and the growing incidence of peri-implant mucositis and peri-implantitis with the current absence of reliable disease risk prediction highlight the importance of early and sensitive diagnosis of possible disease progression. The aim of this study is to assess quantitative and qualitative analysis of peri-implant sulcular fluid (PISF) during implant maintenance control and to identify whether there is a positive correlation and statistical significance between peri-implant sulcular fluid volume results and collagenase2 level obtained from both superficial and fundus area of peri-implant sulcus. MATERIAL AND METHOD: Twenty-seven implants from patients under recall provided peri-implant sulcular fluid volume samples, which were collected with the Periotron 8000 micro-moisture meter, and collagenase2 levels, which were assessed using dentoTest aMMP8. Statistical analysis was obtained using Spearman's correlation. RESULTS: Positive correlation was found between collagenase2 collected from sulcular and fundus areas on both mesial and distal sides. There was correlation between peri-implant sulcular fluid volume and collagenase2 level from fundus and distal area, but not from the mesial and superficial area. CONCLUSIONS: Examination of collagenase2 is a sensitive method when examining early inflammatory changes but depends from the depth of the sample collection in the gingival pocket. CLINICAL RELEVANCE: The examination of MMP8 seems to be a more sensitive method than the analysis of peri-implant sulcular fluid to detect peri-implant mucositis and peri-implantitis.
Authors: Luciene Cristina Figueiredo; Bruno Bueno-Silva; Cristiana Fernandes Plutarco Nogueira; Leonardo Carneiro Valadares; Katia Marina Morilla Garcia; Givelton Coimbra da Luz Filho; Luciano Milanello; Felipe Machado Esteves; Jamil Awad Shibli; Tamires Szeremeske Miranda Journal: Int J Environ Res Public Health Date: 2020-12-06 Impact factor: 3.390
Authors: Darius Gleiznys; Albertas Kriauciunas; Julius Maminskas; Arturas Stumbras; Dalia Giedrimiene; Christine Niekrash; Alvydas Gleiznys; Jurgina Sakalauskiene; Astra Vitkauskiene Journal: Med Sci Monit Date: 2021-10-26