PURPOSE: The insulin-signaling pathway plays a pivotal role in cancer biology; however, evidence of genetic alterations in human studies is limited. This case-control study nested within the Framingham Heart Study (FHS) examined the association between inherited genetic variation in the insulin receptor (INSR) gene and obesity-related cancer risk. METHODS: The study sample consisted of 1,475 controls and 396 cases from the second familial generation of the FHS. Participants who provided consent were genotyped. Nineteen single-nucleotide polymorphisms (SNPs) in the INSR gene were investigated in relation to risk of obesity-related cancers combined and breast, prostate and colorectal cancers. Generalized estimation equation models controlling for familial correlations and include age, sex, smoking and body mass index as covariates, assuming additive models, were used. RESULTS: Three SNPs, rs2059807, s8109559 and rs919275, were significantly associated with obesity-related cancers (p value < 0.02) with the most significantly associated SNP being rs2059807 (p value = 0.008). Carriers of two copies of SNP rs2059807 risk allele T were significantly less prevalent among subjects with obesity-related cancers [f(TT)cases = 14 vs. f(TT)controls = 18 %; OR 1.23]. In exploratory analyses evaluating site-specific cancers, the INSR rs2059807 association with these cancers was consistent with that observed for the main outcome (ORs colorectal cancer = 1.5, breast cancer = 1.29, prostate = 1.06). There was no statistically significant interaction between the INSR-SNP and blood glucose in relation to obesity-related cancer. CONCLUSIONS: The INSR gene is implicated in obesity-related cancer risk, as 3 of 19 SNPs were nominally associated, after false discovery rate (FDR) correction, with the main outcome. Risk allele homozygotes (rs2059807) were less prevalent among subjects with obesity-related cancer. These results should be replicated in other populations to confirm the findings.
PURPOSE: The insulin-signaling pathway plays a pivotal role in cancer biology; however, evidence of genetic alterations in human studies is limited. This case-control study nested within the Framingham Heart Study (FHS) examined the association between inherited genetic variation in the insulin receptor (INSR) gene and obesity-related cancer risk. METHODS: The study sample consisted of 1,475 controls and 396 cases from the second familial generation of the FHS. Participants who provided consent were genotyped. Nineteen single-nucleotide polymorphisms (SNPs) in the INSR gene were investigated in relation to risk of obesity-related cancers combined and breast, prostate and colorectal cancers. Generalized estimation equation models controlling for familial correlations and include age, sex, smoking and body mass index as covariates, assuming additive models, were used. RESULTS: Three SNPs, rs2059807, s8109559 and rs919275, were significantly associated with obesity-related cancers (p value < 0.02) with the most significantly associated SNP being rs2059807 (p value = 0.008). Carriers of two copies of SNP rs2059807 risk allele T were significantly less prevalent among subjects with obesity-related cancers [f(TT)cases = 14 vs. f(TT)controls = 18 %; OR 1.23]. In exploratory analyses evaluating site-specific cancers, the INSRrs2059807 association with these cancers was consistent with that observed for the main outcome (ORs colorectal cancer = 1.5, breast cancer = 1.29, prostate = 1.06). There was no statistically significant interaction between the INSR-SNP and blood glucose in relation to obesity-related cancer. CONCLUSIONS: The INSR gene is implicated in obesity-related cancer risk, as 3 of 19 SNPs were nominally associated, after false discovery rate (FDR) correction, with the main outcome. Risk allele homozygotes (rs2059807) were less prevalent among subjects with obesity-related cancer. These results should be replicated in other populations to confirm the findings.
Authors: H Kim; H Kadowaki; H Sakura; M Odawara; K Momomura; Y Takahashi; Y Miyazaki; T Ohtani; Y Akanuma; Y Yazaki Journal: Diabetologia Date: 1992-03 Impact factor: 10.122
Authors: Meng Chen; Adrian Cassidy; Jian Gu; George L Delclos; Fan Zhen; Hushan Yang; Michelle A T Hildebrandt; Jie Lin; Yuanqing Ye; Robert M Chamberlain; Colin P Dinney; Xifeng Wu Journal: Carcinogenesis Date: 2009-12 Impact factor: 4.944
Authors: Myrto Barrdahl; Federico Canzian; Mia M Gaudet; Susan M Gapstur; Antonia Trichopoulou; Kostas Tsilidis; Carla H van Gils; Signe Borgquist; Elisabete Weiderpass; Kay-Tee Khaw; Graham G Giles; Roger L Milne; Loic Le Marchand; Christopher Haiman; Sara Lindström; Peter Kraft; David J Hunter; Regina Ziegler; Stephen J Chanock; Xiaohong R Yang; Julie E Buring; I-Min Lee; Rudolf Kaaks; Daniele Campa Journal: Int J Cancer Date: 2017-11-17 Impact factor: 7.396
Authors: Marquitta J White; O Risse-Adams; P Goddard; M G Contreras; J Adams; D Hu; C Eng; S S Oh; A Davis; K Meade; E Brigino-Buenaventura; M A LeNoir; K Bibbins-Domingo; M Pino-Yanes; E G Burchard Journal: Immunogenetics Date: 2016-05-03 Impact factor: 2.846
Authors: Su Yon Jung; Thomas Rohan; Howard Strickler; Jennifer Bea; Zuo-Feng Zhang; Gloria Ho; Carolyn Crandall Journal: PLoS One Date: 2017-10-12 Impact factor: 3.240