Francisco E Vera-Badillo1, Martin C Chang2, Gordana Kuruzar3, Alberto Ocana4, Arnoud J Templeton1, Bostjan Seruga5, Robyn Goldstein1, Philippe L Bedard1, Ian F Tannock1, Eitan Amir1. 1. Division of Medical Oncology and Hematology, Department of Medicine, Princess Margaret Cancer Centre, University of Toronto, Toronto, Canada. 2. Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada. 3. Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada. 4. Medical Oncology Department and Translational Research Unit, Albacete University Hospital, Albacete, Spain. 5. Sector of Medical Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia.
Abstract
BACKGROUND: The mechanisms underlying the favourable prognosis of androgen receptor (AR) expression in breast cancer are unknown. METHODS: The associations between the 21-gene recurrence score (RS), AR, grade, mitotic score, Ki-67 and estrogen receptor (ER) and progesterone receptor (PgR) expression were explored in sequential women with lymph node-negative, ER-positive and HER2-negative breast cancer. Statistical significance of this exploratory study was defined as p<0.10. RESULTS: Analysis comprised 70 women. Most tumours had high AR expression (97% had scores >3). Median RS was 15 (range 1-53). AR expression showed a minimally significant positive correlation with ER (R=0.37), but no correlation with Ki-67 (R=-0.18). In univariable analysis, AR (p=0.01), ER (p<0.001) and PgR (p<0.001) had significant negative associations with RS. Ki-67 (p=0.16), grade (p=0.40) and mitotic score (p=0.23) showed no association with RS. Multivariable analysis showed similar associations. CONCLUSIONS: AR is associated with lower RS, but not with Ki-67. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
BACKGROUND: The mechanisms underlying the favourable prognosis of androgen receptor (AR) expression in breast cancer are unknown. METHODS: The associations between the 21-gene recurrence score (RS), AR, grade, mitotic score, Ki-67 and estrogen receptor (ER) and progesterone receptor (PgR) expression were explored in sequential women with lymph node-negative, ER-positive and HER2-negative breast cancer. Statistical significance of this exploratory study was defined as p<0.10. RESULTS: Analysis comprised 70 women. Most tumours had high AR expression (97% had scores >3). Median RS was 15 (range 1-53). AR expression showed a minimally significant positive correlation with ER (R=0.37), but no correlation with Ki-67 (R=-0.18). In univariable analysis, AR (p=0.01), ER (p<0.001) and PgR (p<0.001) had significant negative associations with RS. Ki-67 (p=0.16), grade (p=0.40) and mitotic score (p=0.23) showed no association with RS. Multivariable analysis showed similar associations. CONCLUSIONS:AR is associated with lower RS, but not with Ki-67. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
Entities:
Keywords:
BREAST CANCER; HORMONE; MOLECULAR ONCOLOGY
Authors: Sara Bravaccini; Sara Ravaioli; Dino Amadori; Emanuela Scarpi; Maurizio Puccetti; Andrea Rocca; Maria Maddalena Tumedei; Nestory Masalu; Jackson Kahima; Akwilina Pangan; Lucas Faustine; Alberto Farolfi; Roberta Maltoni; Massimiliano Bonafè; Patrizia Serra; Giuseppe Bronte Journal: Front Endocrinol (Lausanne) Date: 2018-03-29 Impact factor: 5.555