| Literature DB >> 26075704 |
Rémi Desmet1, Mindaugas Pauzuolis1, Emmanuelle Boll1, Hervé Drobecq1, Laurent Raibaut1, Oleg Melnyk1.
Abstract
SEA ligation proceeds chemoselectively at pH 3, i.e., at a pH where the O-acyl isopeptides are protected by protonation. This property was used for synthesizing unprotected O-acyl isopeptides in water, starting from peptide segments which are easily accessible by the Fmoc SPPS.Entities:
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Year: 2015 PMID： 26075704 DOI： 10.1021/acs.orglett.5b01614
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005