Literature DB >> 26075536

Age-related testosterone decline is due to waning of both testicular and hypothalamic-pituitary function.

Ron Golan1, Jason M Scovell2, Ranjith Ramasamy2.   

Abstract

Hypogonadism is a condition in which the endogenous secretion of testosterone is either insufficient or inadequate to maintain serum testosterone levels within normal range, and may manifest as a variety of signs and symptoms. Age-related hypogonadism is due to a combination of primary hypogonadism (testicular failure) and secondary hypogonadism (hypothalamic-pituitary axis failure). This review provides insight into the mechanisms resulting in the multifactorial nature of acquired androgen-deficiency, and outlines the current controversy regarding testosterone-replacement therapy in aging males.

Entities:  

Keywords:  Aging; hypogonadism; late-onset hypogonadism; testosterone

Mesh：

Substances：

Year:  2015        PMID： 26075536      PMCID： PMC4816459          DOI： 10.3109/13685538.2015.1052392

Source DB:  PubMed          Journal:  Aging Male        ISSN： 1368-5538            Impact factor:   5.892


  34 in total

1.  Identification of late-onset hypogonadism in middle-aged and elderly men.

Authors:  Frederick C W Wu; Abdelouahid Tajar; Jennifer M Beynon; Stephen R Pye; Alan J Silman; Joseph D Finn; Terence W O'Neill; Gyorgy Bartfai; Felipe F Casanueva; Gianni Forti; Aleksander Giwercman; Thang S Han; Krzysztof Kula; Michael E J Lean; Neil Pendleton; Margus Punab; Steven Boonen; Dirk Vanderschueren; Fernand Labrie; Ilpo T Huhtaniemi
Journal:  N Engl J Med       Date:  2010-06-16       Impact factor: 91.245

2.  Re: Testosterone Products: Drug Safety Communication - FDA Cautions about Using Testosterone Products for Low Testosterone due to Aging; Requires Labeling Change to Inform of Possible Increased Risk of Heart Attack and Stroke.

Authors:  Allen D Seftel
Journal:  J Urol       Date:  2015-06-18       Impact factor: 7.450

3.  Characteristics of secondary, primary, and compensated hypogonadism in aging men: evidence from the European Male Ageing Study.

Authors:  Abdelouahid Tajar; Gianni Forti; Terence W O'Neill; David M Lee; Alan J Silman; Joseph D Finn; György Bartfai; Steven Boonen; Felipe F Casanueva; Aleksander Giwercman; Thang S Han; Krzysztof Kula; Fernand Labrie; Michael E J Lean; Neil Pendleton; Margus Punab; Dirk Vanderschueren; Ilpo T Huhtaniemi; Frederick C W Wu
Journal:  J Clin Endocrinol Metab       Date:  2010-02-19       Impact factor: 5.958

4.  Graded inhibition of pulsatile luteinizing hormone secretion by a selective gonadotropin-releasing hormone (GnRH)-receptor antagonist in healthy men: evidence that age attenuates hypothalamic GnRH outflow.

Authors:  Paul Y Takahashi; Peter Y Liu; Pamela D Roebuck; Ali Iranmanesh; Johannes D Veldhuis
Journal:  J Clin Endocrinol Metab       Date:  2005-03-01       Impact factor: 5.958

5.  Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging.

Authors:  S M Harman; E J Metter; J D Tobin; J Pearson; M R Blackman
Journal:  J Clin Endocrinol Metab       Date:  2001-02       Impact factor: 5.958

Review 6.  Steroidogenesis in the fetal testis and its susceptibility to disruption by exogenous compounds.

Authors:  Hayley M Scott; J Ian Mason; Richard M Sharpe
Journal:  Endocr Rev       Date:  2009-11-03       Impact factor: 19.871

7.  Age-related decrease in hypothalamic gonadotropin-releasing hormone (GnRH) gene expression, but not pituitary responsiveness to GnRH, in the male Brown Norway rat.

Authors:  D A Gruenewald; M A Naai; B T Marck; A M Matsumoto
Journal:  J Androl       Date:  2000 Jan-Feb

8.  Anterior pituitary luteinizing hormone secretion during continuous perifusion in aging male rats.

Authors:  L W Kaler; V Critchlow
Journal:  Mech Ageing Dev       Date:  1984 Apr-May       Impact factor: 5.432

9.  Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study.

Authors:  Frederick C W Wu; Abdelouahid Tajar; Stephen R Pye; Alan J Silman; Joseph D Finn; Terence W O'Neill; Gyorgy Bartfai; Felipe Casanueva; Gianni Forti; Aleksander Giwercman; Ilpo T Huhtaniemi; Krzysztof Kula; Margus Punab; Steven Boonen; Dirk Vanderschueren
Journal:  J Clin Endocrinol Metab       Date:  2008-02-12       Impact factor: 5.958

10.  Serum testosterone, dihydrotestosterone and estradiol concentrations in older men self-reporting very good health: the healthy man study.

Authors:  Gideon Sartorius; Sasa Spasevska; Amanda Idan; Leo Turner; Elise Forbes; Anna Zamojska; Carolyn A Allan; Lam P Ly; Ann J Conway; Robert I McLachlan; David J Handelsman
Journal:  Clin Endocrinol (Oxf)       Date:  2012-11       Impact factor: 3.478
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  11 in total

1.  Sleep restriction and testosterone concentrations in young healthy males: randomized controlled studies of acute and chronic short sleep.

Authors:  Isaac Smith; Ismel Salazar; Arindam RoyChoudhury; Marie-Pierre St-Onge
Journal:  Sleep Health       Date:  2019-08-12

2.  Ginsenoside Rg1 ameliorates testicular senescence changes in D‑gal‑induced aging mice via anti‑inflammatory and antioxidative mechanisms.

Authors:  Zi-Ling Wang; Lin-Bo Chen; Zhu Qiu; Xiong-Bin Chen; Ying Liu; Jing Li; Lu Wang; Ya-Ping Wang
Journal:  Mol Med Rep       Date:  2018-03-01       Impact factor: 2.952

3.  Do testosterone supplements enhance response to phosphodiesterase 5 inhibitors in men with erectile dysfunction and hypogonadism: a systematic review and meta-analysis.

Authors:  Jun Zhu; Wei Zhang; Ningjing Ou; Yuxuan Song; Jiaqi Kang; Zhen Liang; Rui Hu; Yongjiao Yang; Xiaoqiang Liu
Journal:  Transl Androl Urol       Date:  2020-04

4.  Distinct Habits Of Sun Exposures Lead To Different Impacts On Some Facial Signs Of Chinese Men Of Different Ages.

Authors:  Frederic Flament; David Amar; Matthieu Forichon; Johanna Caron; Caroline Negre
Journal:  Clin Cosmet Investig Dermatol       Date:  2019-11-15

Review 5.  The Double Edge Sword of Testosterone's Role in the COVID-19 Pandemic.

Authors:  Johnny S Younis; Karl Skorecki; Zaid Abassi
Journal:  Front Endocrinol (Lausanne)       Date:  2021-03-16       Impact factor: 5.555

6.  Reproductive Effects of Nicotinamide on Testicular Function and Structure in Old Male Rats: Oxidative, Apoptotic, Hormonal, and Morphological Analyses.

Authors:  Ceyhan Hacioglu; Fatih Kar; Gungor Kanbak
Journal:  Reprod Sci       Date:  2021-06-08       Impact factor: 3.060

Review 7.  MECHANISMS IN ENDOCRINOLOGY: The sexually dimorphic role of androgens in human metabolic disease.

Authors:  Lina Schiffer; Punith Kempegowda; Wiebke Arlt; Michael W O'Reilly
Journal:  Eur J Endocrinol       Date:  2017-05-31       Impact factor: 6.664

Review 8.  Somatopause, weaknesses of the therapeutic approaches and the cautious optimism based on experimental ageing studies with soy isoflavones.

Authors:  Vladimir Z Ajdžanovic; Svetlana Trifunovic; Dragana Miljic; Branka Šošic-Jurjevic; Branko Filipovic; Marko Miler; Nataša Ristic; Milica Manojlovic-Stojanoski; Verica Miloševic
Journal:  EXCLI J       Date:  2018-03-21       Impact factor: 4.068

Review 9.  Intracrine androgen biosynthesis, metabolism and action revisited.

Authors:  Lina Schiffer; Wiebke Arlt; Karl-Heinz Storbeck
Journal:  Mol Cell Endocrinol       Date:  2017-09-01       Impact factor: 4.102

Review 10.  Could Lower Testosterone in Older Men Explain Higher COVID-19 Morbidity and Mortalities?

Authors:  Luis M Montaño; Bettina Sommer; Héctor Solís-Chagoyán; Bianca S Romero-Martínez; Arnoldo Aquino-Gálvez; Juan C Gomez-Verjan; Eduardo Calixto; Georgina González-Avila; Edgar Flores-Soto
Journal:  Int J Mol Sci       Date:  2022-01-15       Impact factor: 5.923
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