Adam S DeConde1, Jess C Mace2, Shaelene Ashby3, Timothy L Smith2, Richard R Orlandi3, Jeremiah A Alt3. 1. Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of California San Diego, San Diego, CA. 2. Department of Otolaryngology-Head and Neck Surgery, Division of Rhinology, Oregon Health and Science University, Portland, OR. 3. Sinus and Skull Base Surgery Program, Division of Otolaryngology-Head and Neck Surgery, Department of Surgery; University of Utah, Salt Lake City, UT.
Abstract
BACKGROUND: Prior investigations into facial pain associated with chronic rhinosinusitis (CRS) have yielded important results, but have yet to use pain-specific outcome measures. This study seeks to characterize facial pain associated with CRS using validated pain-specific instruments. METHODS: Adults with CRS were enrolled into a prospective, cross-sectional study along with control participants presenting with non-CRS diagnoses. Facial pain was characterized in both groups using the Brief Pain Inventory Short Form (BPI-SF) and the Short-Form McGill Pain Questionnaire (SF-MPQ). CRS-specific measures of disease were measured including the 22-item Sino-Nasal Outcome Test-22 (SNOT-22), nasal endoscopy, and computed tomography scoring. RESULTS: The patients comprised of CRS with nasal polyposis (CRSwNP; n = 25), CRS without nasal polyposis (CRSsNP; n = 30), and control participants (n = 8). Subjects with CRSwNP and CRSsNP were less likely to be pain free than controls (16.0%, 6.7%, and 62.5% respectively, p = 0.001) and carried greater burden of pain as measured by the BPI-SF and SF-MPQ than controls (p = 0.002 and p = 0.017, respectively). Pain in CRS was most commonly located around the eyes and characterized as "throbbing" and "aching." Nasal polyp status was not associated with differences in character, severity, or location of pain. CONCLUSION: Subjects with CRS have a greater burden of facial pain relative to control subjects across several standardized pain measures. Further, facial pain in CRS significantly correlated to quality of life and CRS-specific disease severity measures. Study across larger cohorts using standardized pain measures is warranted to clarify the association of facial pain with CRS.
BACKGROUND: Prior investigations into facial pain associated with chronic rhinosinusitis (CRS) have yielded important results, but have yet to use pain-specific outcome measures. This study seeks to characterize facial pain associated with CRS using validated pain-specific instruments. METHODS: Adults with CRS were enrolled into a prospective, cross-sectional study along with control participants presenting with non-CRS diagnoses. Facial pain was characterized in both groups using the Brief Pain Inventory Short Form (BPI-SF) and the Short-Form McGill Pain Questionnaire (SF-MPQ). CRS-specific measures of disease were measured including the 22-item Sino-Nasal Outcome Test-22 (SNOT-22), nasal endoscopy, and computed tomography scoring. RESULTS: The patients comprised of CRS with nasal polyposis (CRSwNP; n = 25), CRS without nasal polyposis (CRSsNP; n = 30), and control participants (n = 8). Subjects with CRSwNP and CRSsNP were less likely to be pain free than controls (16.0%, 6.7%, and 62.5% respectively, p = 0.001) and carried greater burden of pain as measured by the BPI-SF and SF-MPQ than controls (p = 0.002 and p = 0.017, respectively). Pain in CRS was most commonly located around the eyes and characterized as "throbbing" and "aching." Nasal polyp status was not associated with differences in character, severity, or location of pain. CONCLUSION: Subjects with CRS have a greater burden of facial pain relative to control subjects across several standardized pain measures. Further, facial pain in CRS significantly correlated to quality of life and CRS-specific disease severity measures. Study across larger cohorts using standardized pain measures is warranted to clarify the association of facial pain with CRS.
Authors: Michael S Benninger; Berrylin J Ferguson; James A Hadley; Daniel L Hamilos; Michael Jacobs; David W Kennedy; Donald C Lanza; Bradley F Marple; J David Osguthorpe; James A Stankiewicz; Jack Anon; James Denneny; Ivor Emanuel; Howard Levine Journal: Otolaryngol Head Neck Surg Date: 2003-09 Impact factor: 3.497
Authors: Waleed M Abuzeid; Jess C Mace; Milena L Costa; Luke Rudmik; Zachary M Soler; Grace S Kim; Timothy L Smith; Peter H Hwang Journal: Int Forum Allergy Rhinol Date: 2016-02-16 Impact factor: 3.858
Authors: Daniel R Cox; Shaelene Ashby; Jess C Mace; John M DelGaudio; Timothy L Smith; Richard R Orlandi; Jeremiah A Alt Journal: Int Forum Allergy Rhinol Date: 2016-08-23 Impact factor: 3.858
Authors: Daniel R Cox; Shaelene Ashby; Adam S DeConde; Jess C Mace; Richard R Orlandi; Timothy L Smith; Jeremiah A Alt Journal: Int Forum Allergy Rhinol Date: 2015-11-19 Impact factor: 3.858
Authors: George S Tarasidis; Adam S DeConde; Jess C Mace; Shaelene Ashby; Timothy L Smith; Richard R Orlandi; Jeremiah A Alt Journal: Int Forum Allergy Rhinol Date: 2015-06-22 Impact factor: 3.858
Authors: Edward El Rassi; Jess C Mace; Toby O Steele; Jeremiah A Alt; Timothy L Smith Journal: Int Forum Allergy Rhinol Date: 2015-12-17 Impact factor: 3.858