| Literature DB >> 26071778 |
E V Stelmashook1, A V Stavrovskaya, N G Yamshchikova, A S Ol'shanskii, N A Kapay, O V Popova, L G Khaspekov, V G Skrebitsky, N K Isaev.
Abstract
A single intraperitoneal injection to rats of the mitochondria-targeted plastoquinone antioxidant SkQR1 at dose 1 µmol/kg significantly improved reproduction by the rats of the passive avoidance conditional reflex. In vitro experiments on hippocampal slices showed that a single intraperitoneal injection of SkQR1 24 h before the preparation of the slice significantly increases the synaptic transmission efficiency of the pyramidal neurons of the CA1 field. The findings indicate that SkQR1 has a positive effect on memory processes.Entities:
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Year: 2015 PMID： 26071778 DOI： 10.1134/S0006297915050119
Source DB: PubMed Journal: Biochemistry (Mosc) ISSN： 0006-2979 Impact factor: 2.487