Jürgen Tebbenjohanns1, Claudia Höfer2, Lars Bergmann2, Michael Dedroogh2, Daniela Gaudin2, Axel von Werder2, Klaus Rühmkorf2. 1. Department of Cardiology, Medical Clinic I, Helios Klinikum Hildesheim, Senator-Braun-Allee 33, 31135 Hildesheim, Germany juergen.tebbenjohanns@helios-kliniken.de juergen@tebbenjohanns.net. 2. Department of Cardiology, Medical Clinic I, Helios Klinikum Hildesheim, Senator-Braun-Allee 33, 31135 Hildesheim, Germany.
Abstract
AIMS: Complications such as thermal oesophageal lesions, phrenic nerve injury, and pulmonary haemorrhage were found in cryoballoon (CB) ablation. Whether shortening of freezing times translates into equal efficacy rate and outcome is unknown. The aim of this study was to test the hypothesis that a single freeze cycle per pulmonary vein (PV) without dormant conduction during adenosine infusion is equally effective to standard CB procedure with a bonus freeze after documented PV isolation (PVI). METHODS AND RESULTS: In 53 patients with drug-refractory atrial fibrillation (AF) demonstrating PVI after a single 240 s freeze cycle without PV activity during adenosine no additional bonus freeze was applied (study group). In 139 patients, PVI was performed using a bonus freeze (240 s) after documented PVI (control group). Primary endpoint was recurrence of AF. Secondary endpoint was the assessment of quality of life (QoL-score from 1 to 6, being 1 the best and 6 the worst). Follow-up (FU) was performed at 3, 6, and 12 months. Freedom from symptomatic AF during a mean FU of 458 ± 107 days was achieved in 43 (81%) patients in the study group and in 110 (79%) control patients (P = ns). The QoL-score improved equally in both groups (4.8 ± 0.9 to 2.1 ± 0.7, P < 0.05 and 4.7 ± 0.6 to 2.2 ± 0.6, P < 0.05). Procedure duration (79 ± 14 vs. 98 ± 16 min, P < 0.01) was shorter in the study group. Complication rate was similar in both groups. CONCLUSION: Shortening of freezing times to 4 min per PV without residual dormant PV conduction after adenosine provocation is equally effective to the standard CB ablation protocol using a bonus freeze. Published on behalf of the European Society of Cardiology. All rights reserved.
AIMS: Complications such as thermal oesophageal lesions, phrenic nerve injury, and pulmonary haemorrhage were found in cryoballoon (CB) ablation. Whether shortening of freezing times translates into equal efficacy rate and outcome is unknown. The aim of this study was to test the hypothesis that a single freeze cycle per pulmonary vein (PV) without dormant conduction during adenosine infusion is equally effective to standard CB procedure with a bonus freeze after documented PV isolation (PVI). METHODS AND RESULTS: In 53 patients with drug-refractory atrial fibrillation (AF) demonstrating PVI after a single 240 s freeze cycle without PV activity during adenosine no additional bonus freeze was applied (study group). In 139 patients, PVI was performed using a bonus freeze (240 s) after documented PVI (control group). Primary endpoint was recurrence of AF. Secondary endpoint was the assessment of quality of life (QoL-score from 1 to 6, being 1 the best and 6 the worst). Follow-up (FU) was performed at 3, 6, and 12 months. Freedom from symptomatic AF during a mean FU of 458 ± 107 days was achieved in 43 (81%) patients in the study group and in 110 (79%) control patients (P = ns). The QoL-score improved equally in both groups (4.8 ± 0.9 to 2.1 ± 0.7, P < 0.05 and 4.7 ± 0.6 to 2.2 ± 0.6, P < 0.05). Procedure duration (79 ± 14 vs. 98 ± 16 min, P < 0.01) was shorter in the study group. Complication rate was similar in both groups. CONCLUSION: Shortening of freezing times to 4 min per PV without residual dormant PV conduction after adenosine provocation is equally effective to the standard CB ablation protocol using a bonus freeze. Published on behalf of the European Society of Cardiology. All rights reserved.
Authors: Giacomo Mugnai; Carlo de Asmundis; Burak Hünük; Erwin Ströker; Darragh Moran; Ebru Hacioglu; Diego Ruggiero; Jan Poelaert; Christian Verborgh; Vincent Umbrain; Stefan Beckers; Hugo Enrique Coutino-Moreno; Ken Takarada; Valentina de Regibus; Pedro Brugada; Gian-Battista Chierchia Journal: J Interv Card Electrophysiol Date: 2016-02-12 Impact factor: 1.900
Authors: Christian Hendrik Heeger; Sorin Stefan Popescu; Roza Saraei; Bettina Kirstein; Sascha Hatahet; Omar Samara; Anna Traub; Marcel Fehe; Gabriele D'Ambrosio; Ahmad Keelani; Michael Schlüter; Charlotte Eitel; Julia Vogler; Karl Heinz Kuck; Roland Richard Tilz Journal: Europace Date: 2022-07-15 Impact factor: 5.486
Authors: Christian-H Heeger; Erik Wissner; Peter Wohlmuth; Shibu Mathew; Kentaro Hayashi; Christian Sohns; Bruno Reißmann; Christine Lemes; Tilman Maurer; Ardan M Saguner; Francesco Santoro; Johannes Riedl; Feifan Ouyang; Karl-Heinz Kuck; Andreas Metzner Journal: Clin Res Cardiol Date: 2016-04-16 Impact factor: 5.460
Authors: Buelent Koektuerk; Oezlem Koektuerk; Hikmet Yorgun; Jan-Erik Guelker; Cem Turan; Eduard Gorr; Goekmen Turan; Marc Horlitz; Paul Martin Bansmann Journal: PLoS One Date: 2019-05-03 Impact factor: 3.240