Literature DB >> 26071183

Death following ingestion of methylone.

L Barrios1, H Grison-Hernando2, D Boels3, R Bouquie2, C Monteil-Ganiere2, R Clement4.   

Abstract

Methylone is a synthetic derivative of cathinone. It is sold principally on the Internet in powder form under the name «bath salts». Deaths following consumption are very rare. This report details the first case of a death in France (a 21-year-old man), following ingestion of methylone during an evening with friends. Anoxia was observed at the time of autopsy. Toxicological analyses highlighted a consumption of methylone and cannabis. However, biological analyses showed an absence of ethanol, cocaine, amphetamines, and opiate derivatives. Likewise, no medications were found. High concentrations of methylone were found in the peripheral blood (3.13 mg/L) and in the central blood (6.64 mg/L). Its presence in the gastric contents provides evidence that the substance was taken orally. The dosage of δ9-tetrahydrocannabinol (THC) suggests a recent cannabis consumption (THC 12.9 μg/L, THC-COOH 29.3 μg/L, 11-OH-THC 4.9 μg/L). This case illustrates that the consumption of methylone, which has a reputation of being less «powerful» than ecstasy, is not without its dangers.

Entities:  

Keywords:  Anoxia; Cathinones; Death; Methylone; Respiratory inhibition

Mesh:

Substances:

Year:  2015        PMID: 26071183     DOI: 10.1007/s00414-015-1212-4

Source DB:  PubMed          Journal:  Int J Legal Med        ISSN: 0937-9827            Impact factor:   2.686


  15 in total

1.  Distribution of methylone in four postmortem cases.

Authors:  Brian M Cawrse; Barry Levine; Rebecca A Jufer; David R Fowler; Shawn P Vorce; Amber J Dickson; Justin M Holler
Journal:  J Anal Toxicol       Date:  2012-05-11       Impact factor: 3.367

2.  Acute methylone intoxication in an accidental drowning--a case report.

Authors:  Iain M McIntyre; Catherine E Hamm; Lenore Aldridge; Craig L Nelson
Journal:  Forensic Sci Int       Date:  2013-07-02       Impact factor: 2.395

3.  Methylone and mCPP, two new drugs of abuse?

Authors:  M G Bossong; J P Van Dijk; R J M Niesink
Journal:  Addict Biol       Date:  2005-12       Impact factor: 4.280

4.  Seizures associated with synthetic cathinone exposures in the pediatric population.

Authors:  Kristyn Tekulve; Andreia Alexander; Laura Tormoehlen
Journal:  Pediatr Neurol       Date:  2014-03-05       Impact factor: 3.372

5.  Sudden cardiac death associated with methylone use.

Authors:  Peter N Carbone; David L Carbone; Shaun D Carstairs; Scott A Luzi
Journal:  Am J Forensic Med Pathol       Date:  2013-03       Impact factor: 0.921

6.  Analysis of synthetic cathinones commonly found in bath salts in human performance and postmortem toxicology: method development, drug distribution and interpretation of results.

Authors:  Laureen J Marinetti; Heather M Antonides
Journal:  J Anal Toxicol       Date:  2013-01-29       Impact factor: 3.367

Review 7.  Psychoactive "bath salts": not so soothing.

Authors:  Michael H Baumann; John S Partilla; Kurt R Lehner
Journal:  Eur J Pharmacol       Date:  2012-11-23       Impact factor: 4.432

8.  Repeated doses of methylone, a new drug of abuse, induce changes in serotonin and dopamine systems in the mouse.

Authors:  Raúl López-Arnau; José Martínez-Clemente; Sonia Abad; David Pubill; Jorge Camarasa; Elena Escubedo
Journal:  Psychopharmacology (Berl)       Date:  2014-04-05       Impact factor: 4.530

9.  Testing for designer stimulants: metabolic profiles of 16 synthetic cathinones excreted free in human urine.

Authors:  Victor Uralets; Sumandeep Rana; Stewart Morgan; Wayne Ross
Journal:  J Anal Toxicol       Date:  2014-03-25       Impact factor: 3.367

10.  Methylone and monoamine transporters: correlation with toxicity.

Authors:  Chiharu Sogawa; Norio Sogawa; Kazumi Ohyama; Ruri Kikura-Hanajiri; Yukihiro Goda; Ichiro Sora; Shigeo Kitayama
Journal:  Curr Neuropharmacol       Date:  2011-03       Impact factor: 7.363

View more
  8 in total

1.  Pharmacokinetic Profiles and Pharmacodynamic Effects for Methylone and Its Metabolites in Rats.

Authors:  Joshua S Elmore; Ora Dillon-Carter; John S Partilla; Kayla N Ellefsen; Marta Concheiro; Masaki Suzuki; Kenner C Rice; Marilyn A Huestis; Michael H Baumann
Journal:  Neuropsychopharmacology       Date:  2016-09-23       Impact factor: 7.853

2.  The clinical challenges of synthetic cathinones.

Authors:  Fabrizio Schifano; Flavia Napoletano; Davide Arillotta; Caroline Zangani; Liam Gilgar; Amira Guirguis; John Martin Corkery; Alessandro Vento
Journal:  Br J Clin Pharmacol       Date:  2020-02-03       Impact factor: 4.335

Review 3.  Synthetic Cathinone and Cannabinoid Designer Drugs Pose a Major Risk for Public Health.

Authors:  Aviv M Weinstein; Paola Rosca; Liana Fattore; Edythe D London
Journal:  Front Psychiatry       Date:  2017-08-23       Impact factor: 4.157

4.  Presentations to an urban emergency department in Bern, Switzerland associated with acute recreational drug toxicity.

Authors:  Evangelia Liakoni; Sabine Müller; Adrian Stoller; Meret Ricklin; Matthias E Liechti; Aristomenis K Exadaktylos
Journal:  Scand J Trauma Resusc Emerg Med       Date:  2017-03-07       Impact factor: 2.953

Review 5.  Novel Psychoactive Substances-Recent Progress on Neuropharmacological Mechanisms of Action for Selected Drugs.

Authors:  Zurina Hassan; Oliver G Bosch; Darshan Singh; Suresh Narayanan; B Vicknasingam Kasinather; Erich Seifritz; Johannes Kornhuber; Boris B Quednow; Christian P Müller
Journal:  Front Psychiatry       Date:  2017-08-18       Impact factor: 4.157

6.  Structure Assignment of Seized Products Containing Cathinone Derivatives Using High Resolution Analytical Techniques.

Authors:  João L Gonçalves; Vera L Alves; Joselin Aguiar; Maria J Caldeira; Helena M Teixeira; José S Câmara
Journal:  Metabolites       Date:  2021-02-27

Review 7.  An updated review on synthetic cathinones.

Authors:  Jorge Soares; Vera Marisa Costa; Maria de Lourdes Bastos; Félix Carvalho; João Paulo Capela
Journal:  Arch Toxicol       Date:  2021-06-08       Impact factor: 5.153

Review 8.  Designer drugs: mechanism of action and adverse effects.

Authors:  Dino Luethi; Matthias E Liechti
Journal:  Arch Toxicol       Date:  2020-04-06       Impact factor: 5.153

  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.