Literature DB >> 26071156

Hypertonic saline for bronchiolitis in infants.

Simran Grewal, Ran D Goldman.   

Abstract

QUESTION: Recently, a 1-year-old patient returned from admission in the hospital for bronchiolitis, and the report I received indicated that he was treated with inhaled hypertonic saline, among other treatments. Is this therapy recommended for children in the acute care setting? ANSWER: Bronchiolitis, caused mostly by respiratory syncytial virus, is very common in the winter. It is the most frequent cause of hospitalization in infancy. Several good studies have been conducted in the past decade on the use of nebulized hypertonic saline for bronchiolitis management; however, they offer conflicting results. While there might be a role for the use of nebulized hypertonic saline in children who are hospitalized with bronchiolitis for more than 3 days, treatment in other settings does not confer enough benefit to recommend its use. Copyright© the College of Family Physicians of Canada.

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Year:  2015        PMID: 26071156      PMCID: PMC4463895     

Source DB:  PubMed          Journal:  Can Fam Physician        ISSN: 0008-350X            Impact factor:   3.275


  19 in total

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Journal:  Arch Dis Child       Date:  2002-04       Impact factor: 3.791

2.  Increasing incidence of hospitalization for bronchiolitis among Canadian children, 1980-2000.

Authors:  Joanne M Langley; John C LeBlanc; Bruce Smith; Elaine E L Wang
Journal:  J Infect Dis       Date:  2003-11-10       Impact factor: 5.226

3.  Nebulized 3% hypertonic saline solution treatment in hospitalized infants with viral bronchiolitis.

Authors:  Avigdor Mandelberg; Guy Tal; Michaela Witzling; Eli Someck; Sion Houri; Ami Balin; Israel E Priel
Journal:  Chest       Date:  2003-02       Impact factor: 9.410

4.  Hypertonic saline or high volume normal saline for viral bronchiolitis: mechanisms and rationale.

Authors:  Avigdor Mandelberg; Israel Amirav
Journal:  Pediatr Pulmonol       Date:  2010-01

5.  Nebulized 3% hypertonic saline solution treatment in ambulatory children with viral bronchiolitis decreases symptoms.

Authors:  E Michael Sarrell; Guy Tal; Michaela Witzling; Eli Someck; Sion Houri; Herman A Cohen; Avigdor Mandelberg
Journal:  Chest       Date:  2002-12       Impact factor: 9.410

6.  Clinical practice guideline: the diagnosis, management, and prevention of bronchiolitis.

Authors:  Shawn L Ralston; Allan S Lieberthal; H Cody Meissner; Brian K Alverson; Jill E Baley; Anne M Gadomski; David W Johnson; Michael J Light; Nizar F Maraqa; Eneida A Mendonca; Kieran J Phelan; Joseph J Zorc; Danette Stanko-Lopp; Mark A Brown; Ian Nathanson; Elizabeth Rosenblum; Stephen Sayles; Sinsi Hernandez-Cancio
Journal:  Pediatrics       Date:  2014-11       Impact factor: 7.124

7.  Bronchiolitis: Recommendations for diagnosis, monitoring and management of children one to 24 months of age.

Authors:  Jeremy N Friedman; Michael J Rieder; Jennifer M Walton
Journal:  Paediatr Child Health       Date:  2014-11       Impact factor: 2.253

Review 8.  Epinephrine for bronchiolitis.

Authors:  L Hartling; N Wiebe; K Russell; H Patel; T P Klassen
Journal:  Cochrane Database Syst Rev       Date:  2004

9.  A randomized trial of nebulized 3% hypertonic saline with epinephrine in the treatment of acute bronchiolitis in the emergency department.

Authors:  Simran Grewal; Samina Ali; Don W McConnell; Ben Vandermeer; Terry P Klassen
Journal:  Arch Pediatr Adolesc Med       Date:  2009-11

10.  SABRE: a multicentre randomised control trial of nebulised hypertonic saline in infants hospitalised with acute bronchiolitis.

Authors:  Mark L Everard; Daniel Hind; Kelechi Ugonna; Jennifer Freeman; Mike Bradburn; Cindy L Cooper; Elizabeth Cross; Chin Maguire; Hannah Cantrill; John Alexander; Paul S McNamara
Journal:  Thorax       Date:  2014-12       Impact factor: 9.139

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  4 in total

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Authors:  Teeranai Sakulchit; Ran D Goldman
Journal:  Can Fam Physician       Date:  2016-12       Impact factor: 3.275

2.  Nebulized epinephrine for young children with bronchiolitis.

Authors:  Teeranai Sakulchit; Ran D Goldman
Journal:  Can Fam Physician       Date:  2016-12       Impact factor: 3.275

3.  Epinephrine Improves the Efficacy of Nebulized Hypertonic Saline in Moderate Bronchiolitis: A Randomised Clinical Trial.

Authors:  J Carlos Flores-González; Miguel A Matamala-Morillo; Patricia Rodríguez-Campoy; Juan J Pérez-Guerrero; Belén Serrano-Moyano; Paloma Comino-Vazquez; Encarnación Palma-Zambrano; Rocio Bulo-Concellón; Vanessa Santos-Sánchez; Alfonso M Lechuga-Sancho
Journal:  PLoS One       Date:  2015-11-17       Impact factor: 3.240

4.  Exploring the efficacy of using hypertonic saline for nebulizing treatment in children with bronchiolitis: a meta-analysis of randomized controlled trials.

Authors:  Chia-Wen Hsieh; Chiehfeng Chen; Hui-Chuan Su; Kee-Hsin Chen
Journal:  BMC Pediatr       Date:  2020-09-14       Impact factor: 2.125

  4 in total

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