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Literature DB >> 26071118

The role of H2S bioavailability in endothelial dysfunction.

Rui Wang¹, Csaba Szabo², Fumito Ichinose³, Asif Ahmed⁴, Matthew Whiteman⁵, Andreas Papapetropoulos⁶.

Abstract

Endothelial dysfunction (EDF) reflects pathophysiological changes in the phenotype and functions of endothelial cells that result from and/or contribute to a plethora of cardiovascular diseases. We review the role of hydrogen sulfide (H2S) in the pathogenesis of EDF, one of the fastest advancing research topics. Conventionally treated as an environment pollutant, H2S is also produced in endothelial cells and participates in the fine regulation of endothelial integrity and functions. Disturbed H2S bioavailability has been suggested to be a novel indicator of EDF progress and prognosis. EDF manifests in different forms in multiple pathologies, but therapeutics aimed at remedying altered H2S bioavailability may benefit all.

Entities: Chemical

Keywords: cystathionine gamma-lyase; endothelium-derived hyperpolarizing factor; gasotransmitters; heme oxygenase-1; hydrogen sulfide; nitric oxide

Mesh：

Substances：

Year: 2015 PMID： 26071118 PMCID： PMC4562801 DOI： 10.1016/j.tips.2015.05.007

Source DB: PubMed Journal: Trends Pharmacol Sci ISSN： 0165-6147 Impact factor: 14.819

102 in total

1. Sodium thiosulfate attenuates acute lung injury in mice.

Authors: Masahiro Sakaguchi; Eizo Marutani; Hae-sook Shin; Wei Chen; Kenjiro Hanaoka; Ming Xian; Fumito Ichinose
Journal: Anesthesiology Date: 2014-12 Impact factor: 7.892

2. Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter?

Authors: Rui Wang
Journal: FASEB J Date: 2002-11 Impact factor: 5.191

3. AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro.

Authors: Bartosz Szczesny; Katalin Módis; Kazunori Yanagi; Ciro Coletta; Sophie Le Trionnaire; Alexis Perry; Mark E Wood; Matthew Whiteman; Csaba Szabo
Journal: Nitric Oxide Date: 2014-04-19 Impact factor: 4.427

4. Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse.

Authors: Ling Li; Madhav Bhatia; Yi Zhun Zhu; Yi Chun Zhu; Raina Devi Ramnath; Zhong Jing Wang; Farhana Binte Mohammed Anuar; Matthew Whiteman; Manuel Salto-Tellez; Philip K Moore
Journal: FASEB J Date: 2005-04-29 Impact factor: 5.191

5. Hydrogen sulfide induces nitric oxide release from nitrite.

Authors: Loris Grossi
Journal: Bioorg Med Chem Lett Date: 2009-09-12 Impact factor: 2.823

6. Supression of hemin-mediated oxidation of low-density lipoprotein and subsequent endothelial reactions by hydrogen sulfide (H(2)S).

Authors: Viktória Jeney; Edina Komódi; Emõke Nagy; Abolfazl Zarjou; Gregory M Vercellotti; John W Eaton; György Balla; József Balla
Journal: Free Radic Biol Med Date: 2008-12-06 Impact factor: 7.376

7. H2S-donating sildenafil (ACS6) inhibits superoxide formation and gp91phox expression in arterial endothelial cells: role of protein kinases A and G.

Authors: S Muzaffar; J Y Jeremy; A Sparatore; P Del Soldato; G D Angelini; N Shukla
Journal: Br J Pharmacol Date: 2008-09-01 Impact factor: 8.739

8. The coordination of S-sulfhydration, S-nitrosylation, and phosphorylation of endothelial nitric oxide synthase by hydrogen sulfide.

Authors: Zaid Altaany; YoungJun Ju; Guangdong Yang; Rui Wang
Journal: Sci Signal Date: 2014-09-09 Impact factor: 8.192

9. Cystathionine γ-lyase deficiency protects mice from galactosamine/lipopolysaccharide-induced acute liver failure.

Authors: Kazuhiro Shirozu; Kentaro Tokuda; Eizo Marutani; David Lefer; Rui Wang; Fumito Ichinose
Journal: Antioxid Redox Signal Date: 2013-08-22 Impact factor: 8.401

10. Arterial baroreflex dysfunction impairs ischemia-induced angiogenesis.

Authors: Changning Hao; Zhen-Hao Huang; Shu-Wei Song; Yi-Qin Shi; Xian Wu Cheng; Toyoaki Murohara; Wei Lu; Ding-Feng Su; Jun-Li Duan
Journal: J Am Heart Assoc Date: 2014-05-12 Impact factor: 5.501

51 in total

Review 1. A practical guide to working with H₂S at the interface of chemistry and biology.

Authors: Matthew D Hartle; Michael D Pluth
Journal: Chem Soc Rev Date: 2016-11-07 Impact factor: 54.564

2. L-cysteine/cystathionine-β-synthase-induced relaxation in mouse aorta involves a L-serine/sphingosine-1-phosphate/NO pathway.

Authors: Emma Mitidieri; Danila Gurgone; Elisabetta Caiazzo; Teresa Tramontano; Carla Cicala; Raffaella Sorrentino; Roberta d'Emmanuele di Villa Bianca
Journal: Br J Pharmacol Date: 2019-04-22 Impact factor: 8.739

3. Vasodilatory effect of formaldehyde via the NO/cGMP pathway and the regulation of expression of K_ATP, BK_Ca and L-type Ca²⁺ channels.

Authors: Yun Zhao; Jing Ge; Xiaoxiao Li; Qing Guo; Yuqing Zhu; Jing Song; Luoping Zhang; Shumao Ding; Xu Yang; Rui Li
Journal: Toxicol Lett Date: 2019-04-08 Impact factor: 4.372

4. Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase.

Authors: Maria Peleli; Sofia-Iris Bibli; Zhen Li; Athanasia Chatzianastasiou; Aimilia Varela; Antonia Katsouda; Sven Zukunft; Mariarosaria Bucci; Valentina Vellecco; Constantinos H Davos; Noriyuki Nagahara; Giuseppe Cirino; Ingrid Fleming; David J Lefer; Andreas Papapetropoulos
Journal: Biochem Pharmacol Date: 2020-02-04 Impact factor: 5.858

The role of H2S bioavailability in endothelial dysfunction.

1. Sodium thiosulfate attenuates acute lung injury in mice.

2. Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter?

3. AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro.

4. Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse.

5. Hydrogen sulfide induces nitric oxide release from nitrite.

6. Supression of hemin-mediated oxidation of low-density lipoprotein and subsequent endothelial reactions by hydrogen sulfide (H(2)S).

7. H2S-donating sildenafil (ACS6) inhibits superoxide formation and gp91phox expression in arterial endothelial cells: role of protein kinases A and G.

8. The coordination of S-sulfhydration, S-nitrosylation, and phosphorylation of endothelial nitric oxide synthase by hydrogen sulfide.

9. Cystathionine γ-lyase deficiency protects mice from galactosamine/lipopolysaccharide-induced acute liver failure.

10. Arterial baroreflex dysfunction impairs ischemia-induced angiogenesis.

Review 1. A practical guide to working with H₂S at the interface of chemistry and biology.

2. L-cysteine/cystathionine-β-synthase-induced relaxation in mouse aorta involves a L-serine/sphingosine-1-phosphate/NO pathway.

3. Vasodilatory effect of formaldehyde via the NO/cGMP pathway and the regulation of expression of K_ATP, BK_Ca and L-type Ca²⁺ channels.

4. Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase.

Review 5. Gasotransmitter hydrogen sulfide signaling in neuronal health and disease.

6. Carotid artery stenosis in hypertensive rats impairs dilatory pathways in parenchymal arterioles.

Review 7. A timeline of hydrogen sulfide (H₂S) research: From environmental toxin to biological mediator.

Review 8. Regulation of Aqueous Humor Dynamics by Hydrogen Sulfide: Potential Role in Glaucoma Pharmacotherapy.

9. Hydrogen Sulfide: a Novel Immunoinflammatory Regulator in Rheumatoid Arthritis.

Review 10. Chemical Biology of H₂S Signaling through Persulfidation.

Review 1. A practical guide to working with H2S at the interface of chemistry and biology.

Review 5. Gasotransmitter hydrogen sulfide signaling in neuronal health and disease.

Review 7. A timeline of hydrogen sulfide (H2S) research: From environmental toxin to biological mediator.

Review 8. Regulation of Aqueous Humor Dynamics by Hydrogen Sulfide: Potential Role in Glaucoma Pharmacotherapy.

Review 10. Chemical Biology of H2S Signaling through Persulfidation.

Review 1. A practical guide to working with H₂S at the interface of chemistry and biology.

Review 7. A timeline of hydrogen sulfide (H₂S) research: From environmental toxin to biological mediator.

Review 10. Chemical Biology of H₂S Signaling through Persulfidation.