Literature DB >> 26071008

NTCP opens the door for hepatitis B virus infection.

Huan Yan1, Yang Liu2, Jianhua Sui3, Wenhui Li4.   

Abstract

A liver bile acids transporter, sodium taurocholate cotransporting polypeptide (NTCP, encoded by SLC10A1) was recently identified as a functional receptor for hepatitis B virus (HBV) and its satellite hepatitis D virus (HDV). NTCP-complemented human hepatoma HepG2 cells (HepG2-NTCP) were shown to support infection of HBV and HDV in vitro, providing a much-needed and convenient cell culture system for the viruses. Identification of NTCP as a functional receptor for HBV has significantly advanced our understanding of the viral life cycle and opened new opportunities for developing anti-HBV interventions. This article forms part of a symposium in Antiviral Research on "An unfinished story: from the discovery of the Australia antigen to the development of new curative therapies for hepatitis B".
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Cell culture; Drug development; Hepatitis B virus; Hepatitis D virus; Receptor; Sodium taurocholate cotransporting polypeptide (NTCP)

Mesh：

Substances：

Year:  2015        PMID： 26071008     DOI： 10.1016/j.antiviral.2015.06.002

Source DB:  PubMed          Journal:  Antiviral Res        ISSN： 0166-3542            Impact factor:   5.970


  17 in total

1.  Hepatitis B virus molecular biology and pathogenesis.

Authors:  R Jason Lamontagne; Sumedha Bagga; Michael J Bouchard
Journal:  Hepatoma Res       Date:  2016-07-01

Review 2.  Hepatitis B Virus: Advances in Prevention, Diagnosis, and Therapy.

Authors:  Mindie H Nguyen; Grace Wong; Edward Gane; Jia-Horng Kao; Geoffrey Dusheiko
Journal:  Clin Microbiol Rev       Date:  2020-02-26       Impact factor: 26.132

Review 3.  The current status and future directions of hepatitis B antiviral drug discovery.

Authors:  Liudi Tang; Qiong Zhao; Shuo Wu; Junjun Cheng; Jinhong Chang; Ju-Tao Guo
Journal:  Expert Opin Drug Discov       Date:  2016-11-11       Impact factor: 6.098

Review 4.  Modeling hepatitis B virus infection, immunopathology and therapy in mice.

Authors:  Liang Cheng; Feng Li; Moses T Bility; Christopher M Murphy; Lishan Su
Journal:  Antiviral Res       Date:  2015-06-19       Impact factor: 5.970

Review 5.  Mechanism and treatment of α-amanitin poisoning.

Authors:  Jinfang Xue; Xiran Lou; Deyuan Ning; Ruifei Shao; Guobing Chen
Journal:  Arch Toxicol       Date:  2022-10-21       Impact factor: 6.168

6.  Modification of Three Amino Acids in Sodium Taurocholate Cotransporting Polypeptide Renders Mice Susceptible to Infection with Hepatitis D Virus In Vivo.

Authors:  Wenhui He; Zhiliang Cao; Fengfeng Mao; Bijie Ren; Yunfei Li; Dan Li; Huiyu Li; Bo Peng; Huan Yan; Yonghe Qi; Yinyan Sun; Fengchao Wang; Jianhua Sui; Wenhui Li
Journal:  J Virol       Date:  2016-09-12       Impact factor: 5.103

Review 7.  Hepatitis B virus reverse transcriptase - Target of current antiviral therapy and future drug development.

Authors:  Daniel N Clark; Jianming Hu
Journal:  Antiviral Res       Date:  2015-09-25       Impact factor: 5.970

Review 8.  HBV culture and infectious systems.

Authors:  C Nelson Hayes; Kazuaki Chayama
Journal:  Hepatol Int       Date:  2016-03-02       Impact factor: 6.047

Review 9.  Experimental models of hepatitis B and C - new insights and progress.

Authors:  Emmanuel Thomas; T Jake Liang
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2016-04-14       Impact factor: 46.802

Review 10.  From DCPD to NTCP: the long journey towards identifying a functional hepatitis B virus receptor.

Authors:  Jisu Li; Shuping Tong
Journal:  Clin Mol Hepatol       Date:  2015-09-30
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