Literature DB >> 26070963

Autocrine human growth hormone stimulates the tumor initiating capacity and metastasis of estrogen receptor-negative mammary carcinoma cells.

Yi-Jun Chen1, Xiao Zhang2, Zheng-Sheng Wu3, Jing-Jing Wang1, Amy Yong-Chen Lau1, Tao Zhu4, Peter E Lobie5.   

Abstract

The oncogenic effects of autocrine human growth hormone (hGH) have been intensively investigated in estrogen receptor-positive mammary carcinoma (ER + MC) cells. We demonstrated herein that autocrine hGH promoted cancer stem cell (CSC)-like properties of estrogen receptor-negative mammary carcinoma (ER-MC) cells in vitro. In xenograft studies, autocrine hGH increased the tumor initiating capacity of ER-MC cells. We also observed that autocrine hGH promoted migration and invasion of ER-MC cells in vitro, and metastasis in vivo. Thus, inhibition of hGH is a potential therapeutic strategy to prevent tumor initiation and metastasis of ER-MC.
Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  Cancer stem cell; Human growth hormone; Mammary carcinoma; Metastasis; Tumor initiation

Mesh：

Substances：

Year:  2015        PMID： 26070963     DOI： 10.1016/j.canlet.2015.05.031

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  10 in total

1.  Curcumin prevented human autocrine growth hormone (GH) signaling mediated NF-κB activation and miR-183-96-182 cluster stimulated epithelial mesenchymal transition in T47D breast cancer cells.

Authors:  Ajda Coker-Gurkan; Derya Bulut; Recep Genc; Elif-Damla Arisan; Pınar Obakan-Yerlikaya; Narcin Palavan-Unsal
Journal:  Mol Biol Rep       Date:  2018-11-23       Impact factor: 2.316

Review 2.  Covert actions of growth hormone: fibrosis, cardiovascular diseases and cancer.

Authors:  John J Kopchick; Reetobrata Basu; Darlene E Berryman; Jens O L Jorgensen; Gudmundur Johannsson; Vishwajeet Puri
Journal:  Nat Rev Endocrinol       Date:  2022-06-24       Impact factor: 47.564

3.  Growth hormone receptor antagonism downregulates ATP-binding cassette transporters contributing to improved drug efficacy against melanoma and hepatocarcinoma in vivo.

Authors:  Reetobrata Basu; Yanrong Qian; Samuel Mathes; Joseph Terry; Nathan Arnett; Trent Riddell; Austin Stevens; Kevin Funk; Stephen Bell; Zac Bokal; Courtney Batten; Cole Smith; Isaac Mendez-Gibson; Silvana Duran-Ortiz; Grace Lach; Patricia Alexandra Mora-Criollo; Prateek Kulkarni; Emily Davis; Elizabeth Teaford; Darlene E Berryman; Edward O List; Sebastian Neggers; John J Kopchick
Journal:  Front Oncol       Date:  2022-07-05       Impact factor: 5.738

4.  How interacting pathways are regulated by miRNAs in breast cancer subtypes.

Authors:  Claudia Cava; Antonio Colaprico; Gloria Bertoli; Gianluca Bontempi; Giancarlo Mauri; Isabella Castiglioni
Journal:  BMC Bioinformatics       Date:  2016-11-08       Impact factor: 3.169

5.  Autocrine hGH stimulates oncogenicity, epithelial-mesenchymal transition and cancer stem cell-like behavior in human colorectal carcinoma.

Authors:  Jing-Jing Wang; Qing-Yun Chong; Xin-Bao Sun; Ming-Liang You; Vijay Pandey; Yi-Jun Chen; Qiu-Shi Zhuang; Dong-Xu Liu; Lan Ma; Zheng-Sheng Wu; Tao Zhu; Peter E Lobie
Journal:  Oncotarget       Date:  2017-10-10

6.  Autocrine Human Growth Hormone Promotes Invasive and Cancer Stem Cell-Like Behavior of Hepatocellular Carcinoma Cells by STAT3 Dependent Inhibition of CLAUDIN-1 Expression.

Authors:  Yi-Jun Chen; Ming-Liang You; Qing-Yun Chong; Vijay Pandey; Qiu-Shi Zhuang; Dong-Xu Liu; Lan Ma; Tao Zhu; Peter E Lobie
Journal:  Int J Mol Sci       Date:  2017-06-15       Impact factor: 5.923

7.  The effects of growth hormone on therapy resistance in cancer.

Authors:  Reetobrata Basu; John J Kopchick
Journal:  Cancer Drug Resist       Date:  2019-09-19

8.  Growth Hormone Upregulates Mediators of Melanoma Drug Efflux and Epithelial-to-Mesenchymal Transition In Vitro and In Vivo.

Authors:  Yanrong Qian; Reetobrata Basu; Samuel C Mathes; Nathan A Arnett; Silvana Duran-Ortiz; Kevin R Funk; Alison L Brittain; Prateek Kulkarni; Joseph C Terry; Emily Davis; Jordyn T Singerman; Brooke E Henry; Edward O List; Darlene E Berryman; John J Kopchick
Journal:  Cancers (Basel)       Date:  2020-12-04       Impact factor: 6.639

9.  Promise of cancer stem cell vaccine.

Authors:  Li Zhou; Lin Lu; Max S Wicha; Alfred E Chang; Jian-chuan Xia; Xiubao Ren; Qiao Li
Journal:  Hum Vaccin Immunother       Date:  2015       Impact factor: 3.452

10.  Osteogenically-induced exosomes stimulate osteogenesis of human adipose-derived stem cells.

Authors:  Mengru Zhu; Yang Liu; Hongzhi Qin; Shuang Tong; Qiang Sun; Ting Wang; Hua Zhang; Mengying Cui; Shu Guo
Journal:  Cell Tissue Bank       Date:  2020-11-20       Impact factor: 1.522
  10 in total

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