Kyoko Imoto1, Aiko Okazaki1, Fumitake Onishi2, Yoshiyuki Miyazaki2, Masayuki Okeda2, Shuichiro Yano2, Yukiko Takao3, Yasuyuki Gomi2, Toyokazu Ishikawa2, Yoshinobu Okuno2, Yasuko Mori4, Hiroyasu Iso5, Koichi Yamanishi6, Hideo Asada7. 1. Department of Dermatology, Nara Medical University School of Medicine, Nara, Japan. 2. The Research Foundation for Microbial Diseases of Osaka University, Kagawa, Japan. 3. The Research Foundation for Microbial Diseases of Osaka University, Kagawa, Japan; Public Health, Department of Social and Environmental Medicine, Osaka University, Graduate School of Medicine, Osaka, Japan. 4. Division of Clinical Virology, Department of Microbiology and Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan. 5. Public Health, Department of Social and Environmental Medicine, Osaka University, Graduate School of Medicine, Osaka, Japan. 6. The Research Foundation for Microbial Diseases of Osaka University, Kagawa, Japan; National Institute of Biomedical Innovation, Ibaraki, Japan. 7. Department of Dermatology, Nara Medical University School of Medicine, Nara, Japan. Electronic address: asadah@naramed-u.ac.jp.
Abstract
BACKGROUND: The decline of cell-mediated immunity (CMI) is thought to be related to the risk of postherpetic neuralgia (PHN) as well as herpes zoster (HZ). However, the relationship between immunological condition and the incidence of PHN is still unclear. OBJECTIVE: We conducted a large-scale prospective cohort study to clarify the relationship between immunological factors for varicella-zoster virus (VZV) and the incidence of PHN. METHODS: We carried out a cohort study on VZV immunity in a population living on an island cluster, Shozu County in Japan, and examined the people who developed HZ during a follow-up period of 3 years, with a focus on the relationship between cell-mediated and humoral immunity and the incidence of PHN. A total of 12,522 people over the age of 50 were enrolled in this study, and 401 registrants were diagnosed with HZ, including 79 PHN cases. We evaluated anatomical location and severity of skin lesion, acute pain severity, presence or absence of abnormal sensations, CMI assessed by VZV skin test, and VZV-specific antibody titer measured by serological tests. RESULTS: The incidence of PHN was significantly associated with a weak response to the VZV skin test, as well as facial or lumbosacral localization of skin rash, severe skin lesion, severe acute pain, and presence of abnormal sensations, but not related to VZV-specific antibody titer. CONCLUSION: The incidence of PHN is significantly associated with the decline of VZV-specific CMI, but not related to VZV-specific humoral immunity.
BACKGROUND: The decline of cell-mediated immunity (CMI) is thought to be related to the risk of postherpetic neuralgia (PHN) as well as herpes zoster (HZ). However, the relationship between immunological condition and the incidence of PHN is still unclear. OBJECTIVE: We conducted a large-scale prospective cohort study to clarify the relationship between immunological factors for varicella-zoster virus (VZV) and the incidence of PHN. METHODS: We carried out a cohort study on VZV immunity in a population living on an island cluster, Shozu County in Japan, and examined the people who developed HZ during a follow-up period of 3 years, with a focus on the relationship between cell-mediated and humoral immunity and the incidence of PHN. A total of 12,522 people over the age of 50 were enrolled in this study, and 401 registrants were diagnosed with HZ, including 79 PHN cases. We evaluated anatomical location and severity of skin lesion, acute pain severity, presence or absence of abnormal sensations, CMI assessed by VZV skin test, and VZV-specific antibody titer measured by serological tests. RESULTS: The incidence of PHN was significantly associated with a weak response to the VZV skin test, as well as facial or lumbosacral localization of skin rash, severe skin lesion, severe acute pain, and presence of abnormal sensations, but not related to VZV-specific antibody titer. CONCLUSION: The incidence of PHN is significantly associated with the decline of VZV-specific CMI, but not related to VZV-specific humoral immunity.
Authors: Jun Young Kim; Gyeong-Hun Park; Min Ji Kim; Hyun Bo Sim; Weon Ju Lee; Seok-Jong Lee; Shin-Woo Kim; Young Hoon Jeon; Yong Hyun Jang; Do Won Kim Journal: Ann Dermatol Date: 2018-02-21 Impact factor: 1.444
Authors: Neil P Patel; Milica Vukmanovic-Stejic; Mayte Suarez-Farinas; Emma S Chambers; Daisy Sandhu; Judilyn Fuentes-Duculan; Neil A Mabbott; Malcolm H A Rustin; James Krueger; Arne N Akbar Journal: J Infect Dis Date: 2018-09-22 Impact factor: 5.226
Authors: Lei Wang; Erik A M Verschuuren; Coretta C van Leer-Buter; Stephan J L Bakker; Anoek A E de Joode; Johanna Westra; Nicolaas A Bos Journal: Front Immunol Date: 2018-07-16 Impact factor: 7.561