Agnes Galbo Jacobsen1, Mette Dahl Bendtsen2, Henrik Vorum3, Martin Bøgsted4, Janos Hargitai1. 1. Department of Ophthalmology Thy-Mors Hospital, Thisted, Denmark. 2. Department of Clinical Medicine, Aalborg University, Aalborg, Denmark. 3. Department of Ophthalmology, Aalborg University Hospital, Aalborg, Denmark. 4. Department of Clinical Medicine, Aalborg University, Aalborg, Denmark 4Department of Haematology, Aalborg University Hospital, Aalborg, Denmark.
Abstract
PURPOSE: To determine the normal variation in central retinal thickness asymmetry in healthy Caucasian adults using the posterior pole asymmetry analysis (PPAA) of a SPECTRALIS spectral-domain optical coherence tomography (SD-OCT) device. METHODS:Healthy Caucasian individuals aged between 18 and 45 years with a visual acuity of minimum 20/20 and a spherical equivalent between -1.5 and +1.5 diopters were recruited. Retinal thickness and retinal nerve fiber layer thickness (RNFL) were using measured SPECTRALIS SD-OCT. Inter- and intraocular differences in central retinal thickness were calculated using the PPAA. The association between age, sex, and interocular asymmetry was evaluated by a linear model with Gaussian correlation structure. RESULTS:A total of 105 individuals, 30 men and 75 women, were studied. The mean age ± SD was 28.8 ± 7.87 years. The grand mean interocular retinal thickness asymmetry was 5.6 μm (95% confidence interval [CI]: 4.6-6.5) and the grand mean intraocular retinal thickness asymmetry was 8.3 μm (95% CI: 6.8-9.9) in the right eye and 8.4 μm (95% CI: 6.7-10.0) in the left eye. The highest local asymmetries were found in the nasal corners of macula were the posterior pole thickness map overlaps the temporal vascular arches. A slight general age and sex effect on the mean interocular retinal thickness asymmetry was found to be respectively 0.04 μm/year (95% CI: 0.02-0.06 μm) and 0.54 μm (95% CI: 0.19-0.88 μm) for men compared with women. CONCLUSIONS: Statistically significant physiological asymmetries in inter- and intraocular central retinal thickness exist. This must be considered when early signs of glaucoma or other pathologies are evaluated based on the retinal thickness asymmetry. (http://www.controlled-trials.com/isrctn/ number, ISRCTN09017572.).
RCT Entities:
PURPOSE: To determine the normal variation in central retinal thickness asymmetry in healthy Caucasian adults using the posterior pole asymmetry analysis (PPAA) of a SPECTRALIS spectral-domain optical coherence tomography (SD-OCT) device. METHODS: Healthy Caucasian individuals aged between 18 and 45 years with a visual acuity of minimum 20/20 and a spherical equivalent between -1.5 and +1.5 diopters were recruited. Retinal thickness and retinal nerve fiber layer thickness (RNFL) were using measured SPECTRALIS SD-OCT. Inter- and intraocular differences in central retinal thickness were calculated using the PPAA. The association between age, sex, and interocular asymmetry was evaluated by a linear model with Gaussian correlation structure. RESULTS: A total of 105 individuals, 30 men and 75 women, were studied. The mean age ± SD was 28.8 ± 7.87 years. The grand mean interocular retinal thickness asymmetry was 5.6 μm (95% confidence interval [CI]: 4.6-6.5) and the grand mean intraocular retinal thickness asymmetry was 8.3 μm (95% CI: 6.8-9.9) in the right eye and 8.4 μm (95% CI: 6.7-10.0) in the left eye. The highest local asymmetries were found in the nasal corners of macula were the posterior pole thickness map overlaps the temporal vascular arches. A slight general age and sex effect on the mean interocular retinal thickness asymmetry was found to be respectively 0.04 μm/year (95% CI: 0.02-0.06 μm) and 0.54 μm (95% CI: 0.19-0.88 μm) for men compared with women. CONCLUSIONS: Statistically significant physiological asymmetries in inter- and intraocular central retinal thickness exist. This must be considered when early signs of glaucoma or other pathologies are evaluated based on the retinal thickness asymmetry. (http://www.controlled-trials.com/isrctn/ number, ISRCTN09017572.).
Authors: Huiyuan Hou; Sasan Moghimi; Linda M Zangwill; Takuhei Shoji; Elham Ghahari; Patricia Isabel C Manalastas; Rafaella C Penteado; Robert N Weinreb Journal: Am J Ophthalmol Date: 2018-03-24 Impact factor: 5.258
Authors: Eunoo Bak; Young Kook Kim; Ahnul Ha; Young Soo Han; Jin-Soo Kim; Jinho Lee; Yong Woo Kim; Sung Uk Baek; Jin Wook Jeoung; Ki Ho Park Journal: Invest Ophthalmol Vis Sci Date: 2021-07-01 Impact factor: 4.799