Literature DB >> 26069884

Mini-review: Does Notch promote or suppress cancer? New findings and old controversies.

Irina B Grishina1.   

Abstract

Notch signaling in tumorigenesis and cancer progression presents a certain enigma. Numerous experimental studies reported significant effects in cancer, yet of varying magnitude and opposite sign. This mini review is aimed to streamline our understanding of the Notch role in tumor progression, and outline future experiments to clarify the modality of Notch function and perspectives of the Notch-based anticancer treatments.

Entities:  

Keywords:  Notch; PTEN; Wnt; cancer

Year:  2015        PMID： 26069884      PMCID： PMC4446379     

Source DB:  PubMed          Journal:  Am J Clin Exp Urol        ISSN： 2330-1910


  31 in total

1.  Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation.

Authors:  Xi-De Wang; Ching Ching Leow; Jiping Zha; Zhijun Tang; Zora Modrusan; Freddy Radtke; Michel Aguet; Frederic J de Sauvage; Wei-Qiang Gao
Journal:  Dev Biol       Date:  2005-12-15       Impact factor: 3.582

2.  Differentiation of the ductal epithelium and smooth muscle in the prostate gland are regulated by the Notch/PTEN-dependent mechanism.

Authors:  Xinyu Wu; Kun Xu; Lixia Zhang; Yan Deng; Peng Lee; Ellen Shapiro; Marie Monaco; Helen P Makarenkova; Juan Li; Herbert Lepor; Irina Grishina
Journal:  Dev Biol       Date:  2011-05-20       Impact factor: 3.582

Review 3.  Wnt-Notch signalling crosstalk in development and disease.

Authors:  Giovanna M Collu; Ana Hidalgo-Sastre; Keith Brennan
Journal:  Cell Mol Life Sci       Date:  2014-06-19       Impact factor: 9.261

4.  Wnt signaling in castration-resistant prostate cancer: implications for therapy.

Authors:  Noriko N Yokoyama; Shujuan Shao; Bang H Hoang; Dan Mercola; Xiaolin Zi
Journal:  Am J Clin Exp Urol       Date:  2014-04-15

Review 5.  Notch and Wnt inhibitors as potential new drugs for intestinal neoplastic disease.

Authors:  Johan H van Es; Hans Clevers
Journal:  Trends Mol Med       Date:  2005-10-07       Impact factor: 11.951

6.  Nrarp functions to modulate neural-crest-cell differentiation by regulating LEF1 protein stability.

Authors:  Tohru Ishitani; Kunihiro Matsumoto; Ajay B Chitnis; Motoyuki Itoh
Journal:  Nat Cell Biol       Date:  2005-11       Impact factor: 28.824

7.  Mitochondrial dysfunction and dendritic beading during neuronal toxicity.

Authors:  Sam M Greenwood; Sarah M Mizielinska; Bruno G Frenguelli; Jenni Harvey; Christopher N Connolly
Journal:  J Biol Chem       Date:  2007-07-06       Impact factor: 5.157

8.  Conversion of metaplastic Barrett's epithelium into post-mitotic goblet cells by gamma-secretase inhibition.

Authors:  Vivianda Menke; Johan H van Es; Wim de Lau; Maaike van den Born; Ernst J Kuipers; Peter D Siersema; Ron W F de Bruin; Johannes G Kusters; Hans Clevers
Journal:  Dis Model Mech       Date:  2010 Jan-Feb       Impact factor: 5.758

9.  LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis.

Authors:  Juan Galceran; Claudio Sustmann; Shu-Chi Hsu; Stephanie Folberth; Rudolf Grosschedl
Journal:  Genes Dev       Date:  2004-11-15       Impact factor: 11.361

10.  Mathematical models for the Notch and Wnt signaling pathways and the crosstalk between them during somitogenesis.

Authors:  Hong-yan Wang; Yan-xin Huang; Yun-feng Qi; Yu Zhang; Yong-li Bao; Lu-guo Sun; Li-hua Zheng; Yu-wei Zhang; Zhi-qiang Ma; Yu-xin Li
Journal:  Theor Biol Med Model       Date:  2013-04-20       Impact factor: 2.432
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  6 in total

1.  Notch2 as a promising prognostic biomarker for oesophageal squamous cell carcinoma.

Authors:  Cong Wang; Qingbao Li; Fang Liu; Xuan Chen; Bowen Liu; Effat Un Nesa; Shanghui Guan; Lihui Han; Bingxu Tan; Nana Wang; Xintong Wang; Qingxu Song; Yibin Jia; Jianbo Wang; Ming Lu; Yufeng Cheng
Journal:  Sci Rep       Date:  2016-05-09       Impact factor: 4.379

Review 2.  Notch Signaling in Pancreatic Development.

Authors:  Xu-Yan Li; Wen-Jun Zhai; Chun-Bo Teng
Journal:  Int J Mol Sci       Date:  2015-12-30       Impact factor: 5.923

Review 3.  Inflammation and Notch signaling: a crosstalk with opposite effects on tumorigenesis.

Authors:  Chiara Fazio; Luigi Ricciardiello
Journal:  Cell Death Dis       Date:  2016-12-08       Impact factor: 8.469

4.  Na+/H+ exchanger 1 has tumor suppressive activity and prognostic value in esophageal squamous cell carcinoma.

Authors:  Yosuke Ariyoshi; Atsushi Shiozaki; Daisuke Ichikawa; Hiroki Shimizu; Toshiyuki Kosuga; Hirotaka Konishi; Shuhei Komatsu; Hitoshi Fujiwara; Kazuma Okamoto; Mitsuo Kishimoto; Yoshinori Marunaka; Eigo Otsuji
Journal:  Oncotarget       Date:  2017-01-10

5.  Sclareolide enhances gemcitabine‑induced cell death through mediating the NICD and Gli1 pathways in gemcitabine‑resistant human pancreatic cancer.

Authors:  Sheng Chen; Ye Wang; Wen-Long Zhang; Mao-Sheng Dong; Jian-Hua Zhang
Journal:  Mol Med Rep       Date:  2017-02-08       Impact factor: 2.952

6.  Different Expression Levels of DLK2 Inhibit NOTCH Signaling and Inversely Modulate MDA-MB-231 Breast Cancer Tumor Growth In Vivo.

Authors:  Ana-Isabel Naranjo; María-Julia González-Gómez; Victoriano Baladrón; Jorge Laborda; María-Luisa Nueda
Journal:  Int J Mol Sci       Date:  2022-01-29       Impact factor: 5.923
  6 in total

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