Literature DB >> 26069011

The Mouse as Model System to Study Host-Pathogen Interactions in Influenza A Infections.

Esther Wilk1, Klaus Schughart1.   

Abstract

The mouse is one of the most important mammalian model systems for studying host-pathogen-interactions during influenza A virus infections and for assessing the virulence of newly emerging influenza viruses. Here, we provide the basic protocols for infecting mice with influenza virus and studying the main pathological changes associated with disease. Critical parameters, e.g., virus variants and subtypes or mouse strains, are discussed. Curr. Protoc. Mouse Biol. 2:177-205 © 2012 by John Wiley & Sons, Inc.
Copyright © 2012 John Wiley & Sons, Inc.

Entities:  

Keywords:  FFU assay; infection of mice; influenza A virus; influenza pathology

Year:  2012        PMID： 26069011     DOI： 10.1002/9780470942390.mo110173

Source DB:  PubMed          Journal:  Curr Protoc Mouse Biol        ISSN： 2161-2617


  11 in total

1.  Immunization with live virus vaccine protects highly susceptible DBA/2J mice from lethal influenza A H1N1 infection.

Authors:  Leonie Dengler; Mathias May; Esther Wilk; Mahmoud M Bahgat; Klaus Schughart
Journal:  Virol J       Date:  2012-09-19       Impact factor: 4.099

2.  Protection from Severe Influenza Virus Infections in Mice Carrying the Mx1 Influenza Virus Resistance Gene Strongly Depends on Genetic Background.

Authors:  Dai-Lun Shin; Bastian Hatesuer; Silke Bergmann; Tatiana Nedelko; Klaus Schughart
Journal:  J Virol       Date:  2015-07-22       Impact factor: 5.103

3.  The interferon-induced gene Ifi27l2a is active in lung macrophages and lymphocytes after influenza A infection but deletion of Ifi27l2a in mice does not increase susceptibility to infection.

Authors:  Mohamed A Tantawy; Bastian Hatesuer; Esther Wilk; Leonie Dengler; Nadine Kasnitz; Siegfried Weiß; Klaus Schughart
Journal:  PLoS One       Date:  2014-09-03       Impact factor: 3.240

4.  Host Genetic Background Strongly Affects Pulmonary microRNA Expression before and during Influenza A Virus Infection.

Authors:  Matthias Preusse; Klaus Schughart; Frank Pessler
Journal:  Front Immunol       Date:  2017-03-21       Impact factor: 7.561

5.  Of mice and men: the host response to influenza virus infection.

Authors:  Heike Kollmus; Carolin Pilzner; Sarah R Leist; Mark Heise; Robert Geffers; Klaus Schughart
Journal:  Mamm Genome       Date:  2018-06-15       Impact factor: 2.957

6.  Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative Cross.

Authors:  Kelsey E Noll; Alan C Whitmore; Ande West; Mary K McCarthy; Clayton R Morrison; Kenneth S Plante; Brea K Hampton; Heike Kollmus; Carolin Pilzner; Sarah R Leist; Lisa E Gralinski; Vineet D Menachery; Alexandra Schäfer; Darla Miller; Ginger Shaw; Michael Mooney; Shannon McWeeney; Fernando Pardo-Manuel de Villena; Klaus Schughart; Thomas E Morrison; Ralph S Baric; Martin T Ferris; Mark T Heise
Journal:  Cell Rep       Date:  2020-04-28       Impact factor: 9.423

7.  RNAseq expression analysis of resistant and susceptible mice after influenza A virus infection identifies novel genes associated with virus replication and important for host resistance to infection.

Authors:  Esther Wilk; Ashutosh K Pandey; Sarah Rebecca Leist; Bastian Hatesuer; Matthias Preusse; Claudia Pommerenke; Junxi Wang; Klaus Schughart
Journal:  BMC Genomics       Date:  2015-09-02       Impact factor: 3.969

8.  Tmprss2 is essential for influenza H1N1 virus pathogenesis in mice.

Authors:  Bastian Hatesuer; Stephanie Bertram; Nora Mehnert; Mahmoud M Bahgat; Peter S Nelson; Stefan Pöhlmann; Stefan Pöhlman; Klaus Schughart
Journal:  PLoS Pathog       Date:  2013-12-05       Impact factor: 6.823

9.  Cellular changes in blood indicate severe respiratory disease during influenza infections in mice.

Authors:  Leonie Dengler; Nora Kühn; Dai-Lun Shin; Bastian Hatesuer; Klaus Schughart; Esther Wilk
Journal:  PLoS One       Date:  2014-07-24       Impact factor: 3.240

10.  The Proteolytic Activation of (H3N2) Influenza A Virus Hemagglutinin Is Facilitated by Different Type II Transmembrane Serine Proteases.

Authors:  Nora Kühn; Silke Bergmann; Nadine Kösterke; Ruth L O Lambertz; Anna Keppner; Judith M A van den Brand; Stefan Pöhlmann; Siegfried Weiß; Edith Hummler; Bastian Hatesuer; Klaus Schughart
Journal:  J Virol       Date:  2016-04-14       Impact factor: 5.103
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