Alejandro Diaz1, Matías Tringler2, Cintia Galli3, Agustín Ramirez3,4, Edmundo Ignacio Cabrera Fischer3. 1. School of Health Sciences (UNICEN), National Council of Technical and Scientifical Research (CONICET), 4 de Abril 618, 7000, Tandil, Provincia de Buenos Aires, Argentina. alejandrounicen@gmail.com. 2. School of Health Sciences (UNICEN), National Council of Technical and Scientifical Research (CONICET), 4 de Abril 618, 7000, Tandil, Provincia de Buenos Aires, Argentina. 3. Favaloro University (AIDUF-CONICET), Solís 453, 1078, Buenos Aires, Argentina. 4. Arterial Hypertension and Metabolic Unit, University Hospital, Fundación Favaloro, Belgrano 1782 P: 4, 1093, Buenos Aires, Argentina.
Abstract
INTRODUCTION: Aortic stiffness evaluated through pulse wave velocity (PWV) measurement is nowadays accepted as a reliable parameter to estimate cardiovascular risk. However the data about arterial stiffness in South America come from urban populations. AIMS: To determine the relationship between PWV changes and ageing and to identify the rate of change in each decade of life. METHODS: PWV was measured in the carotid-femoral pathway in 400 inhabitants of Vela town and clinical parameters were recorded. RESULTS: The prevalence of hypertension, dyslipidemia and diabetes was 33.5, 17.5, 5% respectively. PWV was positively correlated with age (r: 0.817, p = 0.01) and was greater after the fifth decade of life (9.72 ± 2.2 vs. 5.87 ± 1.55 m/s; p: 0.001) than in youngers than 50 years, respectively. The risk (odds ratio) of having PWV >10 m/s was higher in hypertensives (OR: 50, p = 0.001), older than 50 years (OR: 44, p = 0.001), diabetics (OR 9.5, p = 0.001) and dyslipidemic patients (OR: 5, p = 0.001). CONCLUSIONS: This is the first study in a rural population of Argentina which determines the relationship of PWV with age and cardiovascular risk. PWV shows a slower growth in subjects less than 50 years compared to older adults with a strong relationship to the process of arterial aging, the development of hypertension and cardiovascular risk.
INTRODUCTION: Aortic stiffness evaluated through pulse wave velocity (PWV) measurement is nowadays accepted as a reliable parameter to estimate cardiovascular risk. However the data about arterial stiffness in South America come from urban populations. AIMS: To determine the relationship between PWV changes and ageing and to identify the rate of change in each decade of life. METHODS: PWV was measured in the carotid-femoral pathway in 400 inhabitants of Vela town and clinical parameters were recorded. RESULTS: The prevalence of hypertension, dyslipidemia and diabetes was 33.5, 17.5, 5% respectively. PWV was positively correlated with age (r: 0.817, p = 0.01) and was greater after the fifth decade of life (9.72 ± 2.2 vs. 5.87 ± 1.55 m/s; p: 0.001) than in youngers than 50 years, respectively. The risk (odds ratio) of having PWV >10 m/s was higher in hypertensives (OR: 50, p = 0.001), older than 50 years (OR: 44, p = 0.001), diabetics (OR 9.5, p = 0.001) and dyslipidemic patients (OR: 5, p = 0.001). CONCLUSIONS: This is the first study in a rural population of Argentina which determines the relationship of PWV with age and cardiovascular risk. PWV shows a slower growth in subjects less than 50 years compared to older adults with a strong relationship to the process of arterial aging, the development of hypertension and cardiovascular risk.
Entities:
Keywords:
Arterial stiffness; Epidemiology; Pulse wave velocity; Rural population
Authors: R Asmar; A Benetos; J Topouchian; P Laurent; B Pannier; A M Brisac; R Target; B I Levy Journal: Hypertension Date: 1995-09 Impact factor: 10.190
Authors: Thomas Sehestedt; Jørgen Jeppesen; Tine W Hansen; Susanne Rasmussen; Kristian Wachtell; Hans Ibsen; Christian Torp-Pedersen; Michael H Olsen Journal: J Hypertens Date: 2012-10 Impact factor: 4.844
Authors: Matías Tringler; Edgardo M Rodriguez; Darío Aguera; John D Molina; Gabriela A Canziani; Alejandro Diaz Journal: High Blood Press Cardiovasc Prev Date: 2012-03-01
Authors: Gary F Mitchell; Shih-Jen Hwang; Ramachandran S Vasan; Martin G Larson; Michael J Pencina; Naomi M Hamburg; Joseph A Vita; Daniel Levy; Emelia J Benjamin Journal: Circulation Date: 2010-01-18 Impact factor: 29.690
Authors: Daniel A Duprez; David R Jacobs; Pamela L Lutsey; David Herrington; Darryl Prime; Pamela Ouyang; R Graham Barr; David A Bluemke Journal: Ethn Dis Date: 2009 Impact factor: 1.847
Authors: Gary F Mitchell; Helen Parise; Emelia J Benjamin; Martin G Larson; Michelle J Keyes; Joseph A Vita; Ramachandran S Vasan; Daniel Levy Journal: Hypertension Date: 2004-05-03 Impact factor: 10.190
Authors: Julio A Chirinos; Jan G Kips; Mary J Roman; Josefina Medina-Lezama; Yan Li; Angela J Woodiwiss; Gavin R Norton; Luc Van Bortel; Ji-Guang Wang; John R Cockcroft; Richard B Devereux; Ian B Wilkinson; Patrick Segers; Carmel M McEniery Journal: Hypertension Date: 2011-05-02 Impact factor: 10.190
Authors: Giuseppe Mancia; Robert Fagard; Krzysztof Narkiewicz; Josep Redon; Alberto Zanchetti; Michael Böhm; Thierry Christiaens; Renata Cifkova; Guy De Backer; Anna Dominiczak; Maurizio Galderisi; Diederick E Grobbee; Tiny Jaarsma; Paulus Kirchhof; Sverre E Kjeldsen; Stéphane Laurent; Athanasios J Manolis; Peter M Nilsson; Luis Miguel Ruilope; Roland E Schmieder; Per Anton Sirnes; Peter Sleight; Margus Viigimaa; Bernard Waeber; Faiez Zannad; Josep Redon; Anna Dominiczak; Krzysztof Narkiewicz; Peter M Nilsson; Michel Burnier; Margus Viigimaa; Ettore Ambrosioni; Mark Caufield; Antonio Coca; Michael Hecht Olsen; Roland E Schmieder; Costas Tsioufis; Philippe van de Borne; Jose Luis Zamorano; Stephan Achenbach; Helmut Baumgartner; Jeroen J Bax; Héctor Bueno; Veronica Dean; Christi Deaton; Cetin Erol; Robert Fagard; Roberto Ferrari; David Hasdai; Arno W Hoes; Paulus Kirchhof; Juhani Knuuti; Philippe Kolh; Patrizio Lancellotti; Ales Linhart; Petros Nihoyannopoulos; Massimo F Piepoli; Piotr Ponikowski; Per Anton Sirnes; Juan Luis Tamargo; Michal Tendera; Adam Torbicki; William Wijns; Stephan Windecker; Denis L Clement; Antonio Coca; Thierry C Gillebert; Michal Tendera; Enrico Agabiti Rosei; Ettore Ambrosioni; Stefan D Anker; Johann Bauersachs; Jana Brguljan Hitij; Mark Caulfield; Marc De Buyzere; Sabina De Geest; Geneviève Anne Derumeaux; Serap Erdine; Csaba Farsang; Christian Funck-Brentano; Vjekoslav Gerc; Giuseppe Germano; Stephan Gielen; Herman Haller; Arno W Hoes; Jens Jordan; Thomas Kahan; Michel Komajda; Dragan Lovic; Heiko Mahrholdt; Michael Hecht Olsen; Jan Ostergren; Gianfranco Parati; Joep Perk; Jorge Polonia; Bogdan A Popescu; Zeljko Reiner; Lars Rydén; Yuriy Sirenko; Alice Stanton; Harry Struijker-Boudier; Costas Tsioufis; Philippe van de Borne; Charalambos Vlachopoulos; Massimo Volpe; David A Wood Journal: Eur Heart J Date: 2013-06-14 Impact factor: 29.983
Authors: Alejandro Diaz; Daniel Bia; Yanina Zócalo; Hugo Manterola; Ignacio Larrabide; Lucas Lo Vercio; Mariana Del Fresno; Edmundo Cabrera Fischer Journal: Int J Hypertens Date: 2018-02-14 Impact factor: 2.420